Does Multidetector CT Attenuation Change in Colon Cancer Liver Metastases Treated with<sup>90</sup>Y Help Predict Metabolic Activity at FDG PET?

Tochetto, Sandra; Rezai, Pedram; Rezvani, Maryam; Nikolaidis, Paul; Berggruen, Senta; Atassi, Bassel; Salem, Riad; Yaghmai, Vahid

doi:10.1148/radiol.09091028

Cited by 26 publications

(16 citation statements)

References 34 publications

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“…Choi and colleagues (9,10) have shown that changes in the attenuation of liver metastases from gastrointestinal stromal tumors after treatment with imatinib mesylate, a tyrosine kinase inhibitor, had higher sensitivity and specificity than anatomic imaging biomarkers in predicting response at fluorine 18 fluorodeoxyglucose positron emission tomography. Similarly, it has been shown that measurement of tumor attenuation change at CT improves the accuracy of assessment of response to yttrium 90 treatment in patients with liver metastasis and may help detect response to therapy earlier than size criteria alone (13). These reports underline the importance of an accurate Implication for Patient Care n Volumetry may be a better method of assessing change in tumor attenuation in response to therapy.…”

Section: Study Cohortmentioning

confidence: 95%

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Hepatic Tumors: Region-of-Interest versus Volumetric Analysis for Quantification of Attenuation at CT

Chalian¹,

Tochetto²,

Töre³

et al. 2012

Radiology

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Section: Study Cohortmentioning

confidence: 95%

“…Narrower 95% limits of agreement were observed with the volumetric attenuation measurements. Change in attenuation of treated liver metastases may reflect response to therapy (13). In this study we did not evaluate the reproducibility of changes in attenuation measurements over time.…”

Section: Interobserver Reproducibilitymentioning

confidence: 96%

Hepatic Tumors: Region-of-Interest versus Volumetric Analysis for Quantification of Attenuation at CT

Chalian¹,

Tochetto²,

Töre³

et al. 2012

Radiology

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“…A recent study of patients with colorectal cancer liver metastases treated with TARE correlated the decrease in attenuation in the metastases with their appearances at FDG PET and demonstrated that changes in CT attenuation at 1 month after therapy may predict tumor response, as shown with FDG PET (24).…”

Section: Modified Ct Response Evaluation Criteria (Choi Criteria)mentioning

confidence: 96%

Assessment of Liver Tumor Response to Therapy: Role of Quantitative Imaging

Gonzalez-Guindalini¹,

Botelho²,

Harmath³

et al. 2013

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Quantitative imaging is the analysis of retrieved numeric data from images with the goal of reducing subjective assessment. It is an increasingly important radiologic tool to assess treatment response in oncology patients. Quantification of response to therapy depends on the tumor type and method of treatment. Anatomic imaging biomarkers that quantify liver tumor response to cytotoxic therapy are based on temporal change in the size of the tumors. Anatomic biomarkers have been incorporated into the World Health Organization criteria and the Response Evaluation Criteria in Solid Tumors (RECIST) versions 1.0 and 1.1. However, the development of novel therapies with different mechanisms of action, such as antiangiogenesis or radioembolization, has required new methods for measuring response to therapy. This need has led to development of tumor- or therapy-specific guidelines such as the Modified CT Response Evaluation (Choi) Criteria for gastrointestinal stromal tumors, the European Association for Study of the Liver (EASL) criteria, and modified RECIST for hepatocellular carcinoma, among many others. The authors review the current quantification criteria used in the evaluation of treatment response in liver tumors, summarizing their indications, advantages, and disadvantages, and discuss future directions with newer methods that have the potential for assessment of treatment response. Knowledge of these quantitative methods is important to facilitate pivotal communication between oncologists and radiologists about cancer treatment, with benefit ultimately accruing to the patient.

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“…Moreover, lesion location and size are potentially influential on the reproducibility of ADC measurement [73]. ADC measurements in respiratory-triggered DWI are significantly higher and less reproducible than in breath-hold and free-breathing DWI [74].…”

Section: Morphological Changesmentioning

confidence: 99%

New Imaging Techniques for 90Y Microsphere Radioembolization

Vouche¹,

Vanderlinden²,

Delatte³

et al. 2011

J Nucl Med Radiat Ther

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Adequate patient selection and treatment planning is crucial for a safe and cost-effective administration of selective internal radiotherapy (SIRT) of malignant liver disease using 90 Y-labelled microspheres. It requires the implementation of multimodality imaging, integrating metabolic, functional and structural characteristics. A multidisciplinary approach is a prerequisite for SIRT, bringing together the knowhow and expertise of radiologists, nuclear medicine physicians, medical physicists, imaging engineers, and radiotherapists. This review discusses the available radiologic (CT/MRI) and nuclear (SPECT/PET) imaging modalities and their specific utility in the different diagnostic phases related to SIRT: wholebody and intrahepatic pre-treatment disease staging, CT and MRI-based angiography, liver-lung shunt assessment, treatment simulation, predictive dosimetry, post-treatment imaging, and SIRT response assessment.

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Does Multidetector CT Attenuation Change in Colon Cancer Liver Metastases Treated with⁹⁰Y Help Predict Metabolic Activity at FDG PET?

Abstract: Changes in attenuation of colon cancer liver metastases treated with (90)Y radioembolization correlate highly with metabolic activity at FDG PET and may be useful as an early surrogate marker for assessing treatment response.

Cited by 26 publications

References 34 publications

Hepatic Tumors: Region-of-Interest versus Volumetric Analysis for Quantification of Attenuation at CT

Hepatic Tumors: Region-of-Interest versus Volumetric Analysis for Quantification of Attenuation at CT

Assessment of Liver Tumor Response to Therapy: Role of Quantitative Imaging

New Imaging Techniques for 90Y Microsphere Radioembolization

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Does Multidetector CT Attenuation Change in Colon Cancer Liver Metastases Treated with90Y Help Predict Metabolic Activity at FDG PET?

Abstract: Changes in attenuation of colon cancer liver metastases treated with (90)Y radioembolization correlate highly with metabolic activity at FDG PET and may be useful as an early surrogate marker for assessing treatment response.

Cited by 26 publications

References 34 publications

Hepatic Tumors: Region-of-Interest versus Volumetric Analysis for Quantification of Attenuation at CT

Hepatic Tumors: Region-of-Interest versus Volumetric Analysis for Quantification of Attenuation at CT

Assessment of Liver Tumor Response to Therapy: Role of Quantitative Imaging

New Imaging Techniques for 90Y Microsphere Radioembolization

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Does Multidetector CT Attenuation Change in Colon Cancer Liver Metastases Treated with⁹⁰Y Help Predict Metabolic Activity at FDG PET?