2021
DOI: 10.1111/ijcp.14852
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Does naringenin supplementation improve lipid profile, severity of hepatic steatosis and probability of liver fibrosis in overweight/obese patients with NAFLD? A randomised, double‐blind, placebo‐controlled, clinical trial

Abstract: Background and Objectives: Naringenin has been reported to have some promising pharmacological effects on the management of obesity and related metabolic complications including non-alcoholic fatty liver disease (NAFLD). Therefore, the present clinical trial study was done to assess the effects of naringenin supplementation on lipid profile, aminotransferase levels, severity of steatosis, as well as probability of fibrosis in overweight/obese patients with NAFLD. Materials and Methods: This placebo-controlled,… Show more

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Cited by 32 publications
(24 citation statements)
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“…Previously, an HA methanol extract was shown to diminish the glucose rise after sucrose ingestion, 42 while a reduction of triacylglycerols was only demonstrated in investigations of separate compounds, such as naringenin. 22 Apigenin, present in HA but not in HI, was also efficient in reducing serum triglycerides and total cholesterol in mice. 43 The influence of HA on the metabolism of cholesterol is well known.…”
Section: Discussionmentioning
confidence: 94%
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“…Previously, an HA methanol extract was shown to diminish the glucose rise after sucrose ingestion, 42 while a reduction of triacylglycerols was only demonstrated in investigations of separate compounds, such as naringenin. 22 Apigenin, present in HA but not in HI, was also efficient in reducing serum triglycerides and total cholesterol in mice. 43 The influence of HA on the metabolism of cholesterol is well known.…”
Section: Discussionmentioning
confidence: 94%
“…18 Of the bioactive compounds, isosalipurposide has been shown to exert a cytoprotective effect against oxidative damage in hepatocytes. 52 Naringenin successfully reduced the NAFLD grade in human together with a decrease in serum cholesterol but not ALT and AST, 22 whereas in an animal model it prevented a nanoparticle-induced rise in ALT and AST. 53 In our HI group, ALT and AST were not significantly changed but the decrease in bilirubin was similar in both groups, pointing to a positive influence of both infusions on liver health.…”
Section: Discussionmentioning
confidence: 99%
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“…More importantly, the natural bioactive compounds derived from edible plants may possess therapeutic and protective effects but only minimal toxicity, thus these compounds are recognized as promising sources for developing safe therapeutic drugs or nutritional supplements to treat liver fibrosis. Especially, the edible plant-derived natural compounds as nutritional supplements have been proven highly effective and safe in treating liver diseases in several randomized controlled clinical trials [11][12][13][14].…”
Section: Introductionmentioning
confidence: 99%