Does Nodal Metastasis and Perineural Invasion Affect Local Control in Hyalinizing Clear Cell Carcinoma of the Oral Cavity? A Case Report with Long Term Follow-Up

Le, John; Gubarev, Darya; Ying, Yedeh; Morlandt, Anthony B.

doi:10.1007/s12105-020-01204-5

Cited by 4 publications

(4 citation statements)

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“…High-grade transformation has not been described in hyalinizing clear cell carcinomas over the course of years. 18,19 Even late recurrent cases with high-risk features such as necrosis at initial diagnosis did not show high-grade cytological transformation. 6 Nevertheless, a closer and longer follow-up is required to look for evidence of high-grade transformation in this tumor.…”

Section: Discussionmentioning

confidence: 89%

“…Perineural invasion and lymphovascular invasion are highrisk features associated with worse outcomes and recurrence in tumors arising in the oral cavity which is the commonest site for hyalinizing clear cell carcinoma. 18 In the head and neck region, local recurrence and locoregional nodal metastasis of 49% and 15%, respectively, have been reported. 19 In the bronchial region, infiltration into lung parenchyma, 6 cartilage invasion, 3,4,5 and perineural invasion 5,8 have been documented.…”

Section: Discussionmentioning

confidence: 99%

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Primary Pulmonary Hyalinizing Clear Cell Carcinoma: Case Series With Review of Literature

et al. 2022

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Background: Hyalinizing clear cell carcinomas of tracheobronchial origin are very rare salivary gland type tumors accounting for less than 1% of lung tumors with only 13 cases reported to date. Their radiological features, morphological spectrum, and molecular features are not well described. Aim: To perform a clinicopathological analysis of primary pulmonary hyalinizing clear cell carcinomas. Method: A retrospective search of primary pulmonary hyalinizing clear cell carcinomas was conducted from authors’ institutions and the clinicopathological features including details of molecular testing were analyzed. Results: Five primary pulmonary hyalinizing clear cell carcinomas were identified. The mean patient age at diagnosis was 48.2 years (range: 33-64 years). Three patients were women. All patients were nonsmokers and 3 were symptomatic; 2 were detected incidentally during health screening. The tumors were located in the main lobar bronchi ranging from 1.3 to 4.9 cm in maximum dimension. Microscopy showed cords and nests of at least, focally clear tumor cells. Mucin cysts lacking goblet cells were seen. All tumors were uniformly positive for p40, p63, AE1/AE3, keratin 7, and epithelial membrane antigen but negative for TTF1, KIT, neuroendocrine markers, and other myoepithelial markers. All cases showed Ewing sarcoma breakpoint region 1 ( EWSR1) gene rearrangement. Perineural invasion and lymph node metastases were detected in patient 5. Two patients with available follow-up data were recurrence-free until 4 years (patient 1) and 9 months (patient 5) after resection. Conclusion: The present series adds to the scant available literature on primary pulmonary hyalinizing clear cell carcinomas highlighting the characteristic histomorphology, immunoprofiles, and benign outcomes of these rare tumors.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Hyalinizing Clear Cell Carcinoma: Case Series With Review of Literature

et al. 2022

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“…John M. Le, DDS, MD (Fig 1) and his colleagues in the Department of Oral and Maxillofacial Surgery at the University of Alabama at Birmingham have made a serious impact on global OMS specialty. [4][5][6][7][8][9][10][11][12][13][14][15] Moreover, their article contribution to our journal in 2020 made a huge influence by attracting an international community of readers to our journal, making us enormously proud. The masterpiece was dedicated to the use of zygomatic implants for restoration of complex nasal defects.…”

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confidence: 99%

Meet the Founding Resident Ambassador: John M. Le, DDS, MD

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Fesenko²

2022

J. Diagn. Treat. Oral Maxillofac. Pathol.

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We are happy to continue adopting the best global publishing experience and traditions into the new year of 2022. To start off, we are honored to adopt the progressive tradition held by Plastic and Reconstructive Surgery (PRS) journal. As a phenomenal journal with more than 75 years of publishing developments, PRS serves as a trailblazer for the Journal of Diagnostics and Treatment of Oral and Maxillofacial Pathology. The PRS Editorial Board founded the Resident Ambassador position in 2014 after an unofficial Resident Advisory Board (RAB) meeting of four residents at the 2013 Annual Meeting.2 And now after 7 years, the PRS and PRS Global RAB includes more than 70 members across the world with six PRS and PRS Global Open Resident Ambassadors.2 The RAB serves both PRS and their daughter journal – Plastic and Reconstructive Surgery Global Open (PRS Global Open). The key missions for the members of the RAB are to participate in three of five activities: (1) the PRS journal club on Facebook, (2) the PRS Grand Rounds (a multipronged and multitopic live lectures with question-and-answer series)2 via Facebook, (3) creation of PRS promoting videos on their own social media pages, (4) supporting PRS and PRS Global Open as a peer-reviewers, and (5) voting on the journal’s social media pages. The search for a true leader to take on the role as the Founding Resident Ambassador for the Journal of Diagnostics and Treatment of Oral and Maxillofacial Pathology was an uneasy task. After an extensive search, we are honored to start a collaboration with an oral and maxillofacial surgery (OMS) resident from the state of Alabama in the United States of America. John M. Le, DDS, MD and his colleagues in the Department of Oral and Maxillofacial Surgery at the University of Alabama at Birmingham have made a serious impact on global oral and maxillofacial surgery specialty. Moreover, their article contribution to our journal in 2020 made a huge influence by attracting an international community of readers to our journal, making us enormously proud. The masterpiece was dedicated to the use of zygomatic implants for restoration of complex nasal defects. Thereby, the current academic achievements and research activities of Dr. Le serves as a model for other OMS residents in training. In general, his clinical interests include, but is not limited to head, neck and oral oncology and reconstructive surgery.

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confidence: 99%

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2022

J. Diagn. Treat. Oral Maxillofac. Pathol.

View full text Add to dashboard Cite

We are happy to continue adopting the best global publishing experience and traditions into the new year of 2022. To start off, we are honored to adopt the progressive tradition held by Plastic and Reconstructive Surgery (PRS) journal. As a phenomenal journal with more than 75 years of publishing developments, PRS serves as a trailblazer for the Journal of Diagnostics and Treatment of Oral and Maxillofacial Pathology. The PRS Editorial Board founded the Resident Ambassador position in 2014 after an unofficial Resident Advisory Board (RAB) meeting of four residents at the 2013 Annual Meeting. 2 And now after 7 years, the PRS and PRS Global RAB includes more than 70 members across the world with six PRS and PRS Global Open Resident Ambassadors. 2 The RAB serves both PRS and their daughter journal -Plastic and Reconstructive Surgery Global Open (PRS Global Open). 3 The key missions for the members of the RAB are to participate in three of five activities: (1) the PRS journal club on Facebook, (2) the PRS Grand Rounds (a multipronged and multitopic live lectures with question-and-answer series) 2 via Facebook, (3) creation of PRS promoting videos on their own social media pages, (4) supporting PRS and PRS Global Open as a peer-reviewers, and (5) voting on the journal's social media pages. 3 The search for a true leader to take on the role as the Founding Resident Ambassador for the Journal of Diagnostics and Treatment of Oral and Maxillofacial Pathology was an uneasy task. After an extensive search, we are honored to start a collaboration with an oral and maxillofacial surgery (OMS) resident from the state of Alabama in the United States of America. John M. Le, DDS, MD (Fig 1) and his colleagues in the Department of Oral and Maxillofacial Surgery at the University of Alabama at Birmingham have made a serious impact on global OMS specialty. [4][5][6][7][8][9][10][11][12][13][14][15] Moreover, their article contribution to our journal in 2020 made a huge influence by attracting an international community of readers to our journal, making us enormously proud. The masterpiece was dedicated to the use of zygomatic implants for restoration of complex nasal defects. 15 Thereby,

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Does Nodal Metastasis and Perineural Invasion Affect Local Control in Hyalinizing Clear Cell Carcinoma of the Oral Cavity? A Case Report with Long Term Follow-Up

Cited by 4 publications

References 92 publications

Primary Pulmonary Hyalinizing Clear Cell Carcinoma: Case Series With Review of Literature

Primary Pulmonary Hyalinizing Clear Cell Carcinoma: Case Series With Review of Literature

Meet the Founding Resident Ambassador: John M. Le, DDS, MD

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