Does Non-Alcoholic Fatty Liver Disease (NAFLD) Increase Cardiovascular Risk?

Montecucco, Fabrizio; Mach, François

doi:10.2174/187153008786848268

Cited by 16 publications

(5 citation statements)

References 147 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, we observed a significant up-regulation of TNF-α, IL-6, IL-1β in the liver of P. gingivalis administered mice. TNF-α is a key inflammatory mediator and can be secreted directly by hepatic cells and Kupffer cells [41]. Both human and animal studies have confirmed the role of TNF-α in the development of NAFLD and non-alcoholic steatohepatitis [42].…”

Section: Discussionmentioning

confidence: 99%

Effects on the expression of pro-inflammatory cytokines in the liver and spleen after oral administration of Porphyromonas gingivalis in mice

Ren¹,

Ding²,

Yu³

et al. 2018

biomedicalresearch

View full text Add to dashboard Cite

Periodontitis initiated by periodontopathic bacteria is associated with several systemic diseases.Porphyromonas gingivalis (P. gingivalis) is one of the major pathogens causing periodontal diseases, and is thought to also play a critical role in possible mechanisms linking periodontitis with other systemic disorders. We explored whether the production of pro-inflammatory cytokines interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) in the liver and spleen changed as a result of oral administration of P. gingivalis in mice. mRNA expression of pro-inflammatory cytokines was analysed by Real-time Quantitative polymerase chain reaction (RT-qPCR) and cytokine protein levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA) and immunohistochemistry. In addition, histological changes of liver and spleen tissues were monitored using haematoxylin and eosin staining. The results showed that liver and spleen tissue of P. gingivalis treated mice had higher mRNA and protein levels of pro-inflammatory cytokines compared to the control group. The production of proinflammatory cytokines in the liver and spleen was therefore suggested to increase as a result of oral administration of P. gingivalis in mice, and may provide further understanding of the mechanisms linking periodontitis and systemic disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects on the expression of pro-inflammatory cytokines in the liver and spleen after oral administration of Porphyromonas gingivalis in mice

Ren¹,

Ding²,

Yu³

et al. 2018

biomedicalresearch

View full text Add to dashboard Cite

show abstract

“…Cytokines such as IL-1β, TNF-α, IL-8 and IL-6 have been involved in chronic liver inflammation and pathogenesis of various liver diseases; among which IL-6 and TNF-α, are thought to be most important [26-28]. In this regard, TNF-α and IL-6 were found to positively correlated with the progression of HCC development in humans [29-31].…”

Section: Possible Intermediary Mechanisms Involved In Worsening the Omentioning

confidence: 99%

“…Similarly, TNF-α is secreted by several inflammatory cell types, including monocyte/macrophages, neutrophils, T-cells, kupffer cells and adipose tissue [26,32]. Increased circulating levels of IL-6 and TNF-α have been found in animal models and patients with liver disease including HCC [33].…”

Section: Possible Intermediary Mechanisms Involved In Worsening the Omentioning

confidence: 99%

Insight into the impact of diabetes mellitus on the increased risk of hepatocellular carcinoma: mini-review

Kamkar

Ahmad

Alsmadi

et al. 2014

J Diabetes Metab Disord

View full text Add to dashboard Cite

Hepatocellular carcinoma is a multifactorial disease which is associated with a background of many causal risk factors. Diabetes mellitus however is one of the most common co-morbid illnesses found in hepatocellular carcinoma patients that are significantly associated with worsening of hepatocellular carcinoma development, patient prognosis and survival. Therefore, efforts have been focused on understanding the mechanisms underlying progression of hepatocellular carcinoma onset and development especially in diabetic patients. To our knowledge, there are no reports which address the impact of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) along with epigenetic regulations associated with increased risk of hepatocellular carcinoma confounded by diabetes mellitus. Therefore, this mini-review focuses on the possible intermediary mechanisms involved in worsening the onset and progression of hepatocellular carcinoma development confounded by diabetes mellitus. The first approach is to look at the role of inflammatory mediators (TNF-α and IL-6) in apoptosis and inflammation during hepatocarcinogenesis through monitoring levels of apoptotic regulators, B-cell lymphoma 2 protein which is encoded by BCL2 gene and apoptosis regulator BAX known as bcl-2-like protein 4 which is encoded by the BAX gene. The second approach is to focus on the possible epigenomic reprogramming that drives hepatocellular transformation since epigenetic modification of DNA is a key feature in the pathogenesis of hepatocarcinogenesis. Both approaches may suggest role of using Bcl2 and Bax as apoptotic and inflammatory markers for hepatocellular carcinoma detection as well as the importance impact of DNA methylation, hypomethylation or histone modifications as attractive candidates for early-detection biomarkers of hepatocellular carcinoma.

show abstract

“…ROS and lipid peroxidation promotes inflammation in NAFLD ( Begriche et al, 2006 ). ROS induces inflammation by stimulating the secretion of TNF-α ( Montecucco, et al, 2008 ). TNF-α in turn induces the actions of IL-6 ( Selzner, et al, 2003 ), which is involved in steatohepatitis development by sensitizing the liver to injury and promoting apoptosis in hepatocytes ( Braunersreuther et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Avocado oil alleviates non-alcoholic fatty liver disease by improving mitochondrial function, oxidative stress and inflammation in rats fed a high fat–High fructose diet

et al. 2022

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation in hepatocytes, and in advanced stages, by inflammation and fibrosis. Excessive ROS production due to mitochondrial dysfunction contributes to NAFLD development, making the decrease in mitochondrial ROS production an emerging target to alleviate NAFLD. Previously, we have shown that avocado oil, a source of several bioactive compounds with antioxidant effects, decreases oxidative stress by improving the function of the mitochondrial electron transport chain (ETC) and decreasing ROS levels in mitochondria of diabetic and hypertensive rats. Therefore, we tested in this work whether avocado oil alleviates NAFLD by attenuating mitochondrial dysfunction, oxidative stress and inflammation. NAFLD was induced in rats by a high fat—high fructose (HF) diet administered for six (HF6) or twelve (HF12) weeks. Hepatic steatosis, hypertrophy and inflammation were detected in both the HF6 and HF12 groups. Hyperglycemia was observed only in the HF12 group. The HF6 and HF12 groups displayed dyslipidemia, impairments in mitochondrial respiration, complex III activity, and electron transfer in cytochromes in the complex III. This led to an increase in the levels of ROS and lipid peroxidation. The substitution of the HF6 diet by standard chow and avocado oil for 6 weeks (HF6+AVO + D), or supplementation of the HF12 diet with avocado oil (HF12 + AVO), ameliorated NAFLD, hyperglycemia, dyslipidemia, and counteracted mitochondrial dysfunctions and oxidative stress. The substitution of the HF6 diet by standard chow without avocado oil did not correct many of these abnormalities, confirming that the removal of the HF diet is not enough to counteract NAFLD and mitochondrial dysfunction. In summary, avocado oil decreases NAFLD by improving mitochondrial function, oxidative stress, and inflammation.

show abstract

Does Non-Alcoholic Fatty Liver Disease (NAFLD) Increase Cardiovascular Risk?

Cited by 16 publications

References 147 publications

Effects on the expression of pro-inflammatory cytokines in the liver and spleen after oral administration of Porphyromonas gingivalis in mice

Effects on the expression of pro-inflammatory cytokines in the liver and spleen after oral administration of Porphyromonas gingivalis in mice

Insight into the impact of diabetes mellitus on the increased risk of hepatocellular carcinoma: mini-review

Avocado oil alleviates non-alcoholic fatty liver disease by improving mitochondrial function, oxidative stress and inflammation in rats fed a high fat–High fructose diet

Contact Info

Product

Resources

About