Does normal substantia nigra echogenicity make a difference in Parkinson’s disease diagnosis? A real clinical practice follow-up study

Alonso‐Cánovas, Araceli; Moreno, José Luis López-Sendón; Buisán, Javier; Maza, Susana Sainz de la; Costa‐Frossard, Lucienne; García‐Ribas, Guillermo; Felipe-Mimbrera, Alicia de; Matute-Lozano, María Consuelo; Sanz, Beatriz Zarza; Delgado, Rafael Toledano; Corral, Íñigo; Masjuán, Jaime; Martínez-Castrillo, Juan Carlos

doi:10.1007/s00415-018-9006-5

Cited by 6 publications

(16 citation statements)

References 16 publications

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“…Nine related studies [12][13][14][15][16][17][18][19][20] with a total of 1046 participants, which included 669 patients with PD, published between January 2015 and May 2020, with sample sizes ranging from 35 to 409, were included in the final meta-analysis. e diseases differentiated from PD included atypical Parkinsonism (AP), ET, vascular Parkinsonism (VP), isolated adult-onset focal dystonia (FD), and dopa-responsive dystonia (DRB).…”

Section: Basic Characteristics Of the Included Studiesmentioning

confidence: 99%

Transcranial Sonography of the Substantia Nigra for the Differential Diagnosis of Parkinson’s Disease and Other Movement Disorders: A Meta-Analysis

Mei

Yang

et al. 2021

Parkinson's Disease

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This meta-analysis aimed to evaluate the accuracy of hyperechogenicity of the substantia nigra (SN) for the differential diagnosis of Parkinson’s disease (PD) and other movement disorders. We systematically searched the PubMed, EMBASE, Cochrane Library, and China National Knowledge Infrastructure databases for relevant studies published between January 2015 and May 2020. Eligible articles comparing the echogenicity of the SN between patients with PD and those with other movement disorders were screened, and two independent reviewers extracted data according to the inclusion and exclusion criteria. Statistical analyses were conducted using STATA (version 15.0) (Stata Corporation, College Station, TX, USA), Review Manager 5.3 (Cochrane Collaboration), and Meta-DiSc1.4 to assess the pooled diagnostic value of transcranial sonography (TCS) for PD. Nine studies with a total of 1046 participants, including 669 patients with PD, were included in the final meta-analysis. Our meta-analysis demonstrated that hyperechogenicity of the SN had a pooled sensitivity and specificity of 0.85 (0.82, 0.87) and 0.71 (0.66, 0.75), respectively, for distinguishing idiopathic Parkinson’s disease from other movement disorders. Furthermore, the area under the curve of the summary receiver operating characteristic was 0.94. Transcranial sonography of the SN is a valuable tool for the differential diagnosis of PD and other movement disorders.

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Section: Basic Characteristics Of the Included Studiesmentioning

confidence: 99%

Transcranial Sonography of the Substantia Nigra for the Differential Diagnosis of Parkinson’s Disease and Other Movement Disorders: A Meta-Analysis

Mei

Yang

et al. 2021

Parkinson's Disease

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“…The following structures were reproducibly discernible on B‐mode imaging in our study: Midbrain: easily visible structure located in the center of the cranium in the shape of a butterfly with wings representing the peduncles (Figures 3, 6, and 9; Video S3). We found 15 publications that describe midbrain or brainstem landmarks 3–19 Basal cisterns: hyperechoic signals in cisterns around the midbrain with signal intensity lower than bone when compared to opposite skull 19,20 (Figures 3 and 9).…”

Section: Resultsmentioning

confidence: 99%

“…We found 15 publications that describe midbrain or brainstem landmarks. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] b. Basal cisterns: hyperechoic signals in cisterns around the midbrain with signal intensity lower than bone when compared to opposite skull 19,20 (Figures 3 and 9). g. Lateral ventricles: two anechoic structures visible in the temporal or frontal lobes surrounded by hyperechoic margins.…”

Section: Brainmentioning

confidence: 99%

“…14,17,21,[23][24][25][26] One publication described measuring the diameter of lateral ventricle in the coronal planes 27 (Figure 11; Video S2). Twenty-one publications have described visualization of substantia nigra 3,4,7,8,[11][12][13]17,[19][20][21][22]24,[28][29][30][31][32][33][34][35] ; six manuscripts have described basal ganglia visualization. 3,12,14,16,17,20 Artifacts…”

Section: Brainmentioning

confidence: 99%

“…Twenty-one publications have described visualization of substantia nigra 3,4,7,8,[11][12][13]17,[19][20][21][22]24,[28][29][30][31][32][33][34][35] ; six manuscripts have described basal ganglia visualization. 3,12,14,16,17,20 Artifacts…”

Section: Brainmentioning

confidence: 99%

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Brain topography on adult ultrasound images: Techniques, interpretation, and image library

Kapoor

Offnick

Allen

et al. 2022

Journal of Neuroimaging

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Background and Purpose Many studies have explored the possibility of using cranial ultrasound for discerning intracranial pathologies like tumors, hemorrhagic stroke, or subdural hemorrhage in clinical scenarios where computer tomography may not be accessible or feasible. The visualization of intracranial anatomy on B‐mode ultrasound is challenging due to the presence of the skull that limits insonation to a few segments on the temporal bone that are thin enough to allow transcranial transmission of sound. Several artifacts are produced by hyperechoic signals inherent in brain and skull anatomy when images are created using temporal windows. Methods While the literature has investigated the accuracy of diagnosis of intracranial pathology with ultrasound, we lack a reference source for images acquired on cranial topography on B‐mode ultrasound to illustrate the appearance of normal and abnormal structures of the brain and skull. Two investigators underwent hands‐on training in Cranial point‐of‐care ultrasound (c‐POCUS) and acquired multiple images from each patient to obtain the most in‐depth images of brain to investigate all visible anatomical structures and pathology within 24 hours of any CT/MRI imaging done. Results Most reproducible structures visible on c‐POCUS included bony parts and parenchymal structures. Transcranial and abdominal presets were equivalent in elucidating anatomical structures. Brain pathology like parenchymal hemorrhage, cerebral edema, and hydrocephalus were also visualized. Conclusions We present an illustrated anatomical atlas of cranial ultrasound B‐mode images acquired in various pathologies in a critical care environment and compare our findings with published literature by performing a scoping review of literature on the subject.

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Cranial Ultrasound for Intracerebral Pathology

Sarwal

2023

Lessons From the ICU

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Does normal substantia nigra echogenicity make a difference in Parkinson’s disease diagnosis? A real clinical practice follow-up study

Cited by 6 publications

References 16 publications

Transcranial Sonography of the Substantia Nigra for the Differential Diagnosis of Parkinson’s Disease and Other Movement Disorders: A Meta-Analysis

Transcranial Sonography of the Substantia Nigra for the Differential Diagnosis of Parkinson’s Disease and Other Movement Disorders: A Meta-Analysis

Brain topography on adult ultrasound images: Techniques, interpretation, and image library

Cranial Ultrasound for Intracerebral Pathology

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