Contemporary science and religion discourse (SRD) is a large field encompassing various topics, from creationism against evolution to theological anthropology and artificial intelligence, though historically, what is meant by “science” is Western science, and what is meant by “religion” is usually Christianity. Moreover, SRD has been driven mainly from the North American context. The scope of this paper will thus be more focused on Western science and North American Protestant Evangelical Christianity, which hereafter will be referred to as simply Christianity or religion. In this article, I argue that SRD often arises from conflict or intersections where such interdisciplinary dialogue is needed to better understand the topic. However, this also means that topics that seem to agree between religion and science are not discussed in SRD. It is as if the goal of SRD, consciously or unconsciously, is to attain some consensus. Topics that have achieved consensus are not worth interrogating using the interdisciplinary approach of SRD. In this article, I will raise the topic of the holy war on obesity as a case example. From the medical and scientific perspective, obesity is a significant epidemic and problem. Similarly, Christians also see obesity as a problem that their churches can help by reinforcing the need for self-control as a virtue. The alignment of the two fields leaves this subject primarily out of the radar of the academic SRD. Yet I argue here that this unholy alliance needs to be questioned because locating the solution to obesity simply on willpower to lose weight and battle gluttony is short-sighted at best, misleading perhaps, and harmful at worst. This paper calls for a transdisciplinary approach to the SRD on obesity, emphasizing the need to address the multifaceted nature of the problem, which spans physiology, psychology, sociology, economics, culture, and theology. In overlooking the complexity of the problem with its various intersectionalities, both science and religion in SRD have colonized bodies and health. Inherent within this transdisciplinary approach is the exercise of undisciplining SRD and decolonizing bodies. The concept of “undisciplining” involves re-evaluating the problem beyond mere weight loss, addressing interconnected issues such as food supply, government regulations, capitalism, discrimination, and mental health care. The narrative of gluttony as sin, the war metaphor, and the methodologies employed by both religious and scientific communities need to be deconstructed. In conclusion, recognizing the entangled system in which all are complicit, the paper advocates for a more nuanced and comprehensive approach, free from the constraints of traditional disciplinary boundaries and influenced narratives.