Children’s low academic skills are associated with a variety of behavior problems and maladaptive outcomes throughout childhood and adulthood. Given the prevalence of behavioral disorders is approximately 19% of all US children, understanding of the mechanisms through which academic achievement and externalizing behavior problems interact can inform effective intervention to prevent persistent academic failure, chronic behavioral difficulties, and related negative long-term outcomes. The purpose of this study, therefore, was to systematically review research on the association between low academic achievement and externalizing behavior problems, as well as evaluate the research indicating causal linkages, if any, between the two domains. Five databases were searched, including OVID Medline, PsycInfo, Academic Search Premier, ERIC, and Education Resource. Search terms included statistical designs that could support a hypothetical causal association (e.g., structural equation modeling). We screened a total of 1,808 studies, of which 18 met the final inclusion criteria. In total, seven studies reported small negative effects between the two domains, and only 4 reported effect sizes considered small to moderate. All but one reported these effects in the direction of early externalizing behavior problems to academic achievement. There was inconclusive evidence for either a causal or predictive relationship. Implications for future research and educational practice are discussed.