Does Oxytocin Increase Trust in Humans? A Critical Review of Research

Abstract

Behavioral neuroscientists have shown that the neuropeptide oxytocin (OT) plays a key role in social attachment and affiliation in nonhuman mammals. Inspired by this initial research, many social scientists proceeded to examine the associations of OT with trust in humans over the past decade. To conduct this work, they have (a) examined the effects of exogenous OT increase caused by intranasal administration on trusting behavior, (b) correlated individual difference measures of OT plasma levels with measures of trust, and (c) searched for genetic polymorphisms of the OT receptor gene that might be associated with trust. We discuss the different methods used by OT behavioral researchers and review evidence that links OT to trust in humans. Unfortunately, the simplest promising finding associating intranasal OT with higher trust has not replicated well. Moreover, the plasma OT evidence is flawed by how OT is measured in peripheral bodily fluids. Finally, in recent large-sample studies, researchers failed to find consistent associations of specific OT-related genetic polymorphisms and trust. We conclude that the cumulative evidence does not provide robust convergent evidence that human trust is reliably associated with OT (or caused by it). We end with constructive ideas for improving the robustness and rigor of OT research.

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“…This issue has been highlighted by recent large replication attempts in psychology and experimental economics (Open Science Collaboration, 2015;Camerer et al, 2016) as well as by recent critical reviews of oxytocin research on humans (Nave et al, 2015;Lane et al, 2016).…”

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“…16 and 17; but also see ref. 18). However, there has been surprisingly little research examining OT effects on the cognitive dynamics during which feedback modifies cognitive processes and behavioral outcomes.…”