Does Panic Disorder Increase the Risk of Coronary Heart Disease? A Cohort Study of a National Managed Care Database

Gomez-Caminero, Andres; Blumentals, William A.; Russo, Leo; Brown, Regina R; Castilla-Puentes, Ruby

doi:10.1097/01.psy.0000174169.14227.1f

Cited by 77 publications

(42 citation statements)

References 43 publications

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“…As discussed in section 5.2.2. we might suspect that the majority of baseline PD patients were in an early phase of the disease and therefore had lower rates of co-morbid psychiatric disorders than is usually seen in PD patients in psychiatric clinics. A higher rate of co-morbid depression might have contributed to the development of CAD in more patients as co-morbid depression increased the risk for subsequent cardiac events in a cohort study of PD (85). The mean age of the patients was higher than reported in most studies of PD in psychiatric settings.…”

Section: External Validitycontrasting

confidence: 40%

“…However, an extensive review published in 1998 concluded that studies of associations between PD, CAD, and cardiovascular mortality suffer from serious methodological limitations, such as the lack of sound methodological assessment of PD and prospective design (84). Since then, a recently published cohort study of nearly 40.000 persons diagnosed with PD reported that having a PD diagnosis almost doubled the risk for subsequent CAD (85).…”

Section: Quality Of Lifementioning

confidence: 99%

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A 1-year follow-up study of chest-pain patients with and without panic disorder

Dammen

Bringager

Arnesen

et al. 2006

General Hospital Psychiatry

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Section: External Validitycontrasting

confidence: 40%

Section: Quality Of Lifementioning

confidence: 99%

A 1-year follow-up study of chest-pain patients with and without panic disorder

Dammen

Bringager

Arnesen

et al. 2006

General Hospital Psychiatry

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“…Other research has found the presence of anxiety symptoms to be a risk factor for the development of future coronary heart disease. [118] A prospective study of risk for coronary heart disease (CHD) among male veterans (M 5 59.6) found that for each standard deviation of symptom increase, on the Mississippi Scale for Combat-Related PTSD or the Keane PTSD scale, a significant increase in risk for nonfatal myocardial infarction, angina, and fatal CHD was observed. [119] These findings provide evidence that PTSD symptoms may increase the risk for CHD in older men.…”

Section: Comorbidity and Differential Diagnosismentioning

confidence: 99%

Anxiety disorders in older adults: a comprehensive review

Wolitzky-Taylor¹,

Castriotta²,

Lenze³

et al. 2010

Depress. Anxiety

601

398

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This review aims to address issues unique to older adults with anxiety disorders in order to inform potential changes in the DSM-V. Prevalence and symptom expression of anxiety disorders in late life, as well as risk factors, comorbidity, cognitive decline, age of onset, and treatment efficacy for older adults are reviewed. Overall, the current literature suggests: (a) anxiety disorders are common among older age individuals, but less common than in younger adults; (b) overlap exists between anxiety symptoms of younger and older adults, although there are some differences as well as limitations to the assessment of symptoms among older adults; (c) anxiety disorders are highly comorbid with depression in older adults; (d) anxiety disorders are highly comorbid with a number of medical illnesses; (e) associations between cognitive decline and anxiety have been observed; (f) late age of onset is infrequent; and (g) both pharmacotherapy and CBT have demonstrated efficacy for older adults with anxiety. The implications of these findings are discussed and recommendations for the DSM-V are provided, including extending the text section on age-specific features of anxiety disorders in late life and providing information about the complexities of diagnosing anxiety disorders in older adults. Depression and Anxiety 27:190-211, 2010.

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“…In this regard, a study, which assessed a total of 39 920 panic disorder (PD) patients and an equal number of patients without PD, showed that PD patients had a 2-fold increased risk of CHD in the prospective follow-ups (hazard ratio (HR), 1.87; 95% CI, 1.80 -1.91). Also, after controlling for the covariates, PD patients with depression were nearly 3 times more likely to develop CHD (HR, 2.60; 95% CI, 2.30 -3.01) (10).…”

Section: Anxiety As An Etiological Factor For Chdmentioning

confidence: 99%

A Narrative Review of the Relationship Between Coronary Heart Disease and Anxiety

Dahale

Menon

Jaisoorya

2017

Iran J Psychiatry Behav Sci

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Context: Coronary heart disease (CHD) is the most common cause of death and disability in the world. While the relationship between depression and CHD is well documented, anxiety remains understudied, despite its common cooccurrence. Evidence Acquisition: A PubMed (MEDLINE) search was conducted in order to find articles published between January 2000 and December 2015, using the following keywords: "coronary heart disease" and "anxiety". In total, 79 out of 1138 articles were considered relevant by consensus between the authors and were reviewed. Results: According to previous studies, anxiety is suggested to increase the risk of CHD. Anxiety is associated with an increase in cardiac complications, morbidity and mortality. Also, a lower quality of life has been described among patients after acute coronary syndrome, with a few studies reporting contradictory findings. Although studies on anxiety management in CHD are sparse, selective serotonin reuptake inhibitors have been shown to be relatively safe for patients. On the other hand, psychological interventions have not been adequately evaluated, although some studies have revealed their advantages. Conclusions: Evidence suggests that anxiety is associated with the development and course of CHD. Awareness and appropriate training in cardiology settings need to be prioritized to improve early identification and initiation of effective management.

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Does Panic Disorder Increase the Risk of Coronary Heart Disease? A Cohort Study of a National Managed Care Database

Abstract: The risk of CHD associated with a diagnosis of PD suggests the need for cardiologists and internists to monitor panic disorder to ensure a reduction in the risk of CHD.

Cited by 77 publications

References 43 publications

A 1-year follow-up study of chest-pain patients with and without panic disorder

A 1-year follow-up study of chest-pain patients with and without panic disorder

Anxiety disorders in older adults: a comprehensive review

A Narrative Review of the Relationship Between Coronary Heart Disease and Anxiety

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