Does paraaortic lymphadenectomy have a benefit in the treatment of ovarian cancer that is apparently confined to the ovaries?

Poncheville, L. de; Perrotin, Franck; Lefrancq, Thierry; Lansac, J.; Body, G.

doi:10.1016/s0959-8049(00)00377-4

Cited by 17 publications

(11 citation statements)

References 18 publications

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“…Establishing the prognosis for a woman with ovarian cancer is an important part of the evaluation of the disease and the treatment. Multiple factors, eg, age, FIGO-stage, type of histology, tumor grade, residual disease, CA-125 level, ascites, and lymph node status have been reported to be important for the prognosis (12,13) . The prognostic value of lymph node assessment in early ovarian cancer is obvious, since the presence of node metastases upstages the tumors to FIGO stage III (13) .…”

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confidence: 99%

“…Multiple factors, eg, age, FIGO-stage, type of histology, tumor grade, residual disease, CA-125 level, ascites, and lymph node status have been reported to be important for the prognosis (12,13) . The prognostic value of lymph node assessment in early ovarian cancer is obvious, since the presence of node metastases upstages the tumors to FIGO stage III (13) . Various molecular markers have also been reported to be of prognostic value and prognostic indices or prognostic models have been constructed using a combination of these factors (12) .…”

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confidence: 99%

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A new prognostic model comprising p53, EGFR, and tumor grade in early stage epithelial ovarian carcinoma and avoiding the problem of inaccurate surgical staging

Skírnisdóttir

Seidal

Sorbe

2004

Int J Gynecol Cancer

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Abstract. Epithelial ovarian carcinoma rarely occurs because of a single event. Therefore, no single biological tumor factor will give accurate prognostic information for all ovarian cancer patients. On the other hand, a combination of two or more independent factors may yield an improved overall prognostic index. Because FIGO stage is included in most of the previously presented models, inaccurate surgical staging in patients with apparently early disease has been a problem. In a series of 226 patients with epithelial ovarian carcinomas in FIGO stages IA–IIC, a number of clinicopathological factors (age, FIGO stage, histopathologic type, and tumor grade) were studied in relation to the biological factors p53 and epidermal growth factor receptor (EGFR), important regulators of the apoptosis and mitosis. Immunohistochemical techniques were used. All patients received adjuvant radiotherapy or chemotherapy after the primary surgery. Expression of p53 was significantly associated with the tumor grade and disease‐free survival (DFS). EGFR expression was also associated with DFS. In a Cox multivariate analysis, tumor grade, p53 status, and EGFR status were all independent and significant prognostic factors with regard to DFS. A prognostic model was proposed using these factors. A low‐risk group, an intermediate‐risk group, and a high‐risk group were defined. DFS amounted to 89% in the low‐risk group (grades 1–2, p53‐negative, and EGFR‐negative), 66% in the intermediate‐risk group (grade 3, p53‐negative, and EGFR‐negative or grades 1–2, p53‐positive or EGFR‐positive) and 39% in the high‐risk group (grade 3, p53‐positive, and EGFR‐positive).

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confidence: 99%

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confidence: 99%

A new prognostic model comprising p53, EGFR, and tumor grade in early stage epithelial ovarian carcinoma and avoiding the problem of inaccurate surgical staging

Skírnisdóttir

Seidal

Sorbe

2004

Int J Gynecol Cancer

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“…However, systematic lymphadenectomy is not yet regarded as the standard surgical procedure because it increases surgical morbidity and its therapeutic significance is uncertain. There have been several reports suggesting that lymphadenectomy improves the prognosis for women with ovarian carcinoma9–11, but others remain unconvinced12, 13. Panici et al 14 carried out a prospective randomized study of women with optimally debulked advanced ovarian carcinoma, and reported that systematic lymphadenectomy improved progression‐free but not overall survival compared to the resection of bulky nodes only.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of intraoperative ultrasonography to assess para‐aortic lymph nodes in women with ovarian and uterine corpus malignancy

Ryo

2008

Ultrasound in Obstet & Gyne

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“…De Poncheville et al (11) disputed the therapeutic role of lymphadenectomy, particularly in early ovarian cancer. These authors stressed the fact that survival of patients with early ovarian cancer following adjuvant chemotherapy is satisfactory.…”

Section: Intraoperative Complicationsmentioning

confidence: 99%

Evaluation of intraoperative and postoperative complications related to lymphadenectomy in ovarian cancer patients

Gmyrek¹,

Jońska-Gmyrek²,

Sobiczewski³

et al. 2011

Oncology Letters

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Abstract. Assessment of the regional lymph node status is an integral part of diagnostics for ovarian cancer patients. Due to the risk of complications, lymphadenectomy for ovarian cancer patients, as a routine treatment procedure, is still a subject of controversy. Therefore, the present study aimed to evaluate the frequency and nature of intraoperative and postoperative complications in ovarian cancer patients treated with surgery. In addition, a comparison of the frequency and nature of surgical complications between patients who underwent lymphadenectomy and those who did not was carried out. A retrospective analysis of 211 consecutive ovarian cancer patients treated with surgery with pelvic and aortic lymphadenectomy (group I), and 258 ovarian cancer patients treated with surgery but without lymphadenectomy (group II) was carried out. All of the patients were treated with complementary chemotherapy. The frequency and nature of the intraoperative and postoperative complications were determined. The most frequent intraoperative complications in the two groups were haemorrhage, urinary system damage and digestive tract damage. The difference in the frequency and nature between the groups was not statistically significant (p=0.683). The most frequent postoperative complications were haemorrhage, intestinal junction dehiscence, eventrations, wound dehiscence, anaemia, wound healing complications and intestinal fistulas. Haemorrhage, eventrations and wound healing complications were more frequent in group I. The difference was statistically significant (p=0.002). Due to postoperative complications, reoperative procedures were necessary in two women in group II (0.78) and in 15 women (7.11%) in group I. The difference was statistically significant (p=0.000). In conclusion, the most frequent intraoperative complications were haemorrhage, urinary system damage and digestive tract damage. The frequency of complication was found to be similar in the two groups. A statistically significant higher rate of postoperative complications, such as haemorrhage, eventrations and wound healing complications was confirmed in the lymphadenectomy group.

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Does paraaortic lymphadenectomy have a benefit in the treatment of ovarian cancer that is apparently confined to the ovaries?

Cited by 17 publications

References 18 publications

A new prognostic model comprising p53, EGFR, and tumor grade in early stage epithelial ovarian carcinoma and avoiding the problem of inaccurate surgical staging

A new prognostic model comprising p53, EGFR, and tumor grade in early stage epithelial ovarian carcinoma and avoiding the problem of inaccurate surgical staging

Diagnostic value of intraoperative ultrasonography to assess para‐aortic lymph nodes in women with ovarian and uterine corpus malignancy

Evaluation of intraoperative and postoperative complications related to lymphadenectomy in ovarian cancer patients

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