Does paracetamol cause asthma?

Nuttall, Sarah; Williams, Joseph; Kendall, M. J.

doi:10.1046/j.1365-2710.2003.00492.x

Cited by 27 publications

(20 citation statements)

References 51 publications

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“…Possible suggested mechanisms whereby acetaminophen intake might increase the risk of asthma and allergic diseases include the depletion of pulmonary glutathione concentration (30,31) and the inhibition of basal INF-a and IL-6 secretion, predisposing the lung to epithelial damage, mast cell activation, excess mucus secretion, and bronchoconstriction (30,31). The animal model used demonstrated that the lung was the first organ in which this depletion action persisted further potentiating other toxic products (32).…”

Section: Discussionmentioning

confidence: 99%

The Role of Acetaminophen and Geohelminth Infection on the Incidence of Wheeze and Eczema

Amberbir¹,

Medhin²,

Alem³

et al. 2011

Am J Respir Crit Care Med

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Rationale: Acetaminophen has been hypothesized to increase the risk of asthma and allergic disease, and geohelminth infection to reduce the risk, but evidence from longitudinal cohort studies is lacking. Objectives: To investigate the independent effects of these exposures on the incidence of wheeze and eczema in a birth cohort. Methods: In 2005-2006 a population-based cohort of 1,065 pregnant women from Butajira, Ethiopia, was established, to whom 1,006 live singleton babies were born. At ages 1 and 3, questionnaire data were collected on wheeze, eczema, child's use of acetaminophen, and various potential confounders, along with a stool sample for geohelminth analysis. Those without wheeze (n 5 756) or eczema (n 5 780) at age 1 were analyzed to determine the independent effects of geohelminth infection and acetaminophen use in the first year of life on the incidence of wheeze and eczema by age 3. Measurements and Main Results: Wheeze and eczema incidence between the ages of 1 and 3 were reported in 7.7% (58 of 756) and 7.3% (57 of 780) of children, respectively. Acetaminophen use was significantly associated with a dose-dependent increased risk of incident wheeze (adjusted odds ratio 5 1.88 and 95% confidence interval 1.03-3.44 for one to three tablets and 7.25 and 2.02-25.95 for >4 tablets in the past month at age 1 vs. never), but not eczema. Geohelminth infection was insufficiently prevalent (,4%) to compute estimates of effect. Conclusions: These findings suggest frequent acetaminophen use early in life increases the risk of new-onset wheeze, whereas the role of geohelminth infection on allergic disease incidence remains to be seen as the cohort matures.

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Section: Discussionmentioning

confidence: 99%

The Role of Acetaminophen and Geohelminth Infection on the Incidence of Wheeze and Eczema

Amberbir¹,

Medhin²,

Alem³

et al. 2011

Am J Respir Crit Care Med

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“…This depletion is proposed to increase the risk of lung tissue damage and ultimately of respiratory disease. 30 Other mechanisms that might link paracetamol to the development of asthma include enhanced production of prostaglandin E 2 to promote T H 2 allergic pathways or an IgE-mediated mechanism with acetaminophen as the antigenic agent. 31 Based on current knowledge, further research into the effects of paracetamol on the incidence of childhood asthma is urgently needed to enable guidelines for the recommended use of paracetamol in childhood to be made.…”

Section: Oxidant Defense In Patients With Asthmamentioning

confidence: 99%

Breakdown in epithelial barrier function in patients with asthma: Identification of novel therapeutic approaches

Swindle

Collins

Davies

2009

Journal of Allergy and Clinical Immunology

102

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“…Oxidative stress appears to play an important role in the development and progression of respiratory diseases. Glutathione (GSH), an endogenous antioxidant, is found in the respiratory tract lining fluid (Cantin et al, 1987), and decreased GSH levels are associated with oxidant damage in the lung (Nuttall et al, 2003). Furthermore, high doses of APAP have been shown to reduce levels of GSH in the lung tissue of animals (Micheli et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten

et al. 2011

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-Acetaminophen (APAP) is one of the most commonly used drugs worldwide to reduce fever, particularly in children. It is generally considered to be a safe drug. However, a number of studies have shown that regular use of APAP increases the risk of developing allergic diseases. Nonetheless, no animal models have been used to investigate these findings. Therefore, we aimed to create an animal model of APAP-induced pruritus in mice. APAP (0.25% and 0.5%) was administered via drinking water daily from infancy, and a suboptimal concentration of 2,4,6-trinitrochlorobenzene (TNCB) was applied repeatedly to each ear three times a week for 7 weeks to evoke chronic allergic contact dermatitis. Neither 0.25% nor 0.5% APAP was overtly hepatotoxic after 73 days of daily administration. Repeated challenge with TNCB evoked increase in the number of scratching bouts compared to day 1. This increase in the number of scratching bouts was significant in 0.25% and 0.5% APAP groups but not in the group treated with TNCB alone. Daily administration of 0.5% APAP significantly increased in the number of scratching bouts compared to TNCB alone on day 29. This animal model will be useful for investigating the mechanism underlying the increased risk of development of eczema caused by regular APAP use and for examining safer and more effective therapy with APAP.

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Does paracetamol cause asthma?

Cited by 27 publications

References 51 publications

The Role of Acetaminophen and Geohelminth Infection on the Incidence of Wheeze and Eczema

The Role of Acetaminophen and Geohelminth Infection on the Incidence of Wheeze and Eczema

Breakdown in epithelial barrier function in patients with asthma: Identification of novel therapeutic approaches

Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten

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