Does particle disease really exist?

Mjöberg, Bengt

doi:10.1080/17453674.2017.1373491

Cited by 8 publications

(6 citation statements)

References 36 publications

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“…This mechanism eventually creates abnormal gaps between the bone-implant interface impeding the natural osseointegration process. Microparticle wear debris derive mainly from artificial joint materials, most commonly from polyethylene wear (8,9,10,39,42,43). These microparticles mediate a foreign body response, releasing several inflammatory cytokines and kinases, which upregulate phagocytes and macrophages (8,9,42,43,44,45).…”

Section: Discussionmentioning

confidence: 99%

“…Insufficient primary fixation and particle-induced osteolysis around the implant have been implicated. Prosthesis micromotion, particulate debris formation and macrophage-activated osteolysis are critically involved in AL pathogenesis (9,10). The risk of AL based on the type of THA bearing surface, design, implant type, coating and porosity has been extensively studied so far (8,9,10,11).…”

Section: Introductionmentioning

confidence: 99%

“…Prosthesis micromotion, particulate debris formation and macrophage-activated osteolysis are critically involved in AL pathogenesis (9,10). The risk of AL based on the type of THA bearing surface, design, implant type, coating and porosity has been extensively studied so far (8,9,10,11). Several diseases, such as diabetes mellitus, rheumatoid arthritis, Parkinson's disease, previous surgical procedures, perioperative drug use, and other comorbidities, have also been evaluated (11,12,13,14,15,16,17).…”

Section: Introductionmentioning

confidence: 99%

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Bisphosphonates’ use and risk of aseptic loosening following total hip arthroplasty: a systematic review

Pegios,

Kenanidis,

Tsotsolis

et al. 2023

EFORT Open Reviews

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Purpose The main indication of bisphosphonates (BPs) is osteoporosis treatment. However, there is growing interest in the peri- and postoperative use of BPs to mitigate total hip arthroplasty (THA) aseptic loosening (AL) risk. This systematic review aimed to evaluate the implant survival and the AL rate in patients with elective THA receiving BPs compared to those that do not receive BPs. Secondary outcomes included the comparison of revision rate, postoperative complications, and patients’ functional scores. Methods This systematic review was conducted under the PRISMA 2020 guidelines with a pre-registered PROSPERO protocol. Three engines and grey literature were searched up until May 2022. Randomized and nonrandomized controlled trials and comparative cohort studies assessing BP and control therapy impact on THA survival were included. Results Twelve studies embraced the inclusion criteria. A total of 99 678 patients and 99 696 THAs were included; 10 025 patients received BPs (BP group), and 89 129 made up the control group. The overall revision and AL rates were lower in the BP group (2.17% and 1.85%) than in the control group (4.06% and 3.2%). Periprosthetic fracture (PPF) cases were higher in the BP group (0.24%) than in the control group (0.04%); however, the majority of PPF cases were derived from a single study. Further complication risk was similar between groups. Most studies reported comparable functional scores between groups. Conclusion BP treatment after elective THA seems to reduce the overall revision and AL risk. Other complications’ risk and functional scores were similar between groups. Further high-quality studies are needed to validate the results due to the multifactorial AL pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bisphosphonates’ use and risk of aseptic loosening following total hip arthroplasty: a systematic review

Pegios,

Kenanidis,

Tsotsolis

et al. 2023

EFORT Open Reviews

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“…The pressure waves may devitalize the adjacent bone tissue, which is resorbed, thus causing a focal osteolysis. From Mjöberg[ 53 ] with permission.…”

Section: Current Understanding Of Looseningmentioning

confidence: 99%

Hip prosthetic loosening: A very personal review

Mjöberg¹

2021

WJO

Self Cite

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Hip prosthetic loosening is often difficult to detect at an early stage, and there has been uncertainty for a long time as to when the loosening occurs and thus to the basic causes. By comparing different diagnostic methods, we found that loosening is best defined as prosthetic migration and measured by radiostereometric analysis. Convincing evidence indicates that poor interlock, poor bone quality, and resorption of a necrotic bone bed may initiate loosening during or shortly after surgery; this forms the basis of the theory of early loosening. Biomechanical factors do affect the subsequent progression of loosening, which may increase subclinically during a long period of time. Eventually, the loosening may be detected on standard radiographs and may be interpreted as late loosening but should to be interpreted as late detection of loosening. The theory of early loosening explains the rapid early migration, the development of periprosthetic osteolysis and granulomas, the causality between wear and loosening, and largely the epidemiology of clinical failure of hip prostheses. Aspects discussed are definition of loosening, the pattern of early migration, the choice of migration threshold, the current understanding of loosening, a less exothermic bone cement, cemented taper-slip stems, a new exciting computed tomography-based technique for simpler implant migration studies, and research suggestions.

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“…However, other causative factors like implant micromotion and high fluid pressure around implants are proposed to induce periprosthetic osteolysis [31]. Whether or not particles are the only culprit behind periprosthetic bone loss has been a matter of debate [32,33].…”

Section: Etiology Of Periprosthetic Osteolysismentioning

confidence: 99%

Aseptic Loosening of Orthopedic Implants : Osteoclastogenesis Regulation and Potential Therapeutics

Amirhosseini

2019

Linköping University Medical Dissertations

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Does particle disease really exist?

Cited by 8 publications

References 36 publications

Bisphosphonates’ use and risk of aseptic loosening following total hip arthroplasty: a systematic review

Bisphosphonates’ use and risk of aseptic loosening following total hip arthroplasty: a systematic review

Hip prosthetic loosening: A very personal review

Aseptic Loosening of Orthopedic Implants : Osteoclastogenesis Regulation and Potential Therapeutics

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