2022
DOI: 10.3389/fphys.2022.904280
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Does Plasma Inhibit the Activity of KCl Cotransport in Red Cells From LK Sheep?

Abstract: Red cells from LK sheep represent an important paradigm for control of KCl cotransport activity, as well as being important to sheep erythroid function. A previous report (Godart et al., 1997) suggested that autologous plasma markedly inhibits red cell KCC activity and identified the presence of the bicarbonate/CO2 buffer system as the probable cause. Findings were restricted, however, to red cells from patients with sickle cell disease (SCD) swollen anisotonically and carried out at a very high O2 tension (c.… Show more

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