Does platelet mass influence the effectiveness of ibuprofen treatment for patent ductus arteriosus in preterm infants?

Abstract

Our data suggest that platelet count, MPV and platelet mass did not affect the closure of hsPDA with ibuprofen.

Platelet mass index and prediction of severity of transient tachypnea of the newborn

“…Platelet dysfunction or defective platelet formation was found to result in persistent DA . Several studies have also reported an association between thrombocytopenia in the first few day of life and PDA in preterm infants, but similar analyses failed to confirm these findings . Two meta‐analyses noted a significant association between low platelet count and hemodynamically significant PDA (hsPDA) on the first day of life, and between pre‐treatment thrombocytopenia and pharmacological treatment failure, respectively .…”

“…38 Several studies have also reported an association between thrombocytopenia in the first few day of life and PDA in preterm infants, [38][39][40][41] but similar analyses failed to confirm these findings. [42][43][44][45][46][47] Two meta-analyses noted a significant association between low platelet count and hemodynamically significant PDA (hsPDA) on the first day of life, and between pre-treatment thrombocytopenia and pharmacological treatment failure, respectively. 48,49 Term neonates with altered platelet number or function including Wiskott-Aldrich syndrome, alloimmune thrombocytopenia, or Glanzmann thrombasthenia, do not show an increased incidence of PDA.…”

A promising, novel index in the diagnosis and follow‐up of patent ductus arteriosus: Red cell distribution width‐to‐platelet ratio

“…Also, in another meta‐analysis, platelet count appeared lower in premature infants who did not respond to the first medical treatment . In the following limited number of studies, the role of platelet indices in ductal patency was investigated, but no clear relationship was found . There is also scant data regarding the value of plateletcrit (PCT) in PDA.…”

“…6 In the following limited number of studies, the role of platelet indices in ductal patency was investigated, but no clear relationship was found. [7][8][9][10][11] There is also scant data regarding the value of plateletcrit (PCT) in PDA.…”

The Fate of Patent Ductus Arteriosus is not Affected by Platelet Count and Mean Platelet Volume in Premature Infants < 32 GestationalWeeks

“…Some studies suggested that platelet count and functions play an important role in the closure of ductus arteriosus, while some others did not find any relationship between the ductal closure and platelet count and functions. [6][7][8] High platelet count and mean platelet volume (MPV) have been shown to support ductal closure by promoting thrombosis inside the lumen of arterial duct. Large platelets are known to be more active.…”