Does platelet-rich fibrin have a role in osseointegration of immediate implants? A randomized, single-blind, controlled clinical trial

Diana, Cathrine; Mohanty, Sujata; Chaudhary, Zainab; Kumari, Saroj; Dabas, Jitender; Bodh, Ranjeet

doi:10.1016/j.ijom.2018.01.001

Cited by 41 publications

(89 citation statements)

References 31 publications

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“…The total success rate of our study at the end of 9 months is 100%. These rates are higher compared to other studies [2,28]. The use of membranes in all groups, no early loading and primary closure may have been effective in this difference.…”

Section: Discussioncontrasting

confidence: 52%

“…Diana et al [2] placed PRF in the buccal gap in a study of 20 immediate implants which 10 of them in the control group. The implants were applied to both maxilla and mandible.…”

Section: Discussionmentioning

confidence: 99%

“…Immediate implant protocol was introduced by Schulte in 1978 to overcome the disadvantages of conventional implant protocol such as time loss and bone resorption [1]. Since then, many studies have been conducted on immediate implants which mention other advantages including protecting alveolar anatomy [2] psychosocial benefits, and cost-effectiveness [3].…”

Section: Introductionmentioning

confidence: 99%

“…To increase the success rate, dentists always seek to fill the gap with a biomaterial that they think improves and accelerates the bone healing. The researchers tried various materials and techniques such as deproteinized bovine bone mineral (DBBM), demineralized freeze-dried bone allograft (DFDBA) [4] guided bone regeneration (GBR) [5] plateletrich plasma (PRP) [6] and platelet-rich fibrin (PRF) [2].…”

Section: Introductionmentioning

confidence: 99%

“…There are studies reporting that the use of PRF in intra-bone defects contributes to a rapid recovery and improved bone formation [8,9]. But some long term studies indicates that PRF could not maintain its superiority to next periods and no significant differences between PRF+ and PRF-groups in terms of implant stability or crestal bone dimensional change [2,9]. GBR is a regenerative method based on the placement of a barrier membrane on the defect site.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Two Different Biomaterials Effect on Immediate Implant Stability and Bone Changes, a Randomized Parallel Group Clinical Trial

Gürses¹,

Esen²

2019

IJSR

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How to rehabilitate the buccal gap of immediate implants is a point that confuses dentists. In this study, we aimed to compare the effect of the plasma rich fibrin(PRF) and deproteinized bovine bone mineral(DBBM) on immediate implants which have gaps wider than 2 mm in terms of stability and crestal bone change. The total number of volunteers in our study is 15. All participants have an indication of extraction on tooth which has two adjacent teeth in the maxillar anterior or premolar region and rehabilitated with immediate implants. All individuals were divided into three groups as DBBM, PRF and Control by envelope method. Stability measurements was performed separately as mesiodistal(MD) and buccolingual(BP) at 0 and 120th day. CBCTs were taken pre-op and post-op 9th month. There was no statistically significant difference between the three groups in terms of mesial/distal and horizontal crest losses, T1-T0 MD and BP changes. The use of PRF or DBBM in the buccal gap can contribute to the stability and prevents vertical and horizontal bone losses.

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Section: Discussioncontrasting

confidence: 52%

“…Diana et al [2] placed PRF in the buccal gap in a study of 20 immediate implants which 10 of them in the control group. The implants were applied to both maxilla and mandible.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Two Different Biomaterials Effect on Immediate Implant Stability and Bone Changes, a Randomized Parallel Group Clinical Trial

Gürses¹,

Esen²

2019

IJSR

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Effect of leukocyte‐platelet‐rich fibrin in bone healing around dental implants placed in conventional and wide osteotomy sites: A pre‐clinical study

et al. 2022

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Leukocyte‐platelet‐rich fibrin (L‐PRF) has been suggested for gap management for immediate implant placement when the distance is greater than 2 mm. However, there remains a paucity in hierarchically designed research to support this application. The present study aimed to evaluate the effect of L‐PRF on the osseointegration parameters of dental implants placed after conventional osteotomy of surgically created bone defects that simulate post extraction sockets in a canine model after 3, 6, and 12 weeks in vivo. Eighty dental implants (Intra‐Lock, Boca Raton, FL) were placed in the radius of 13 beagle dogs. The experiment consisted of 4 groups (n = 20 implants/group): 1) Regular osteotomy (Reg n/L‐PRF); 2) Regular osteotomy and implant placement with L‐PRF membrane (Reg L‐PRF); 3) Wide osteotomy with no gap management performed, where an osteotomy/bony defect (6 mm of diameter and ~5 mm deep) was created to simulate immediate implant placement in post‐extraction sockets, and the gap was left for spontaneous healing (Wide nL‐PRF); and 4) Wide osteotomy with L‐PRF gap management (Wide L‐PRF). L‐PRF membranes were obtained by blood drawn from each subject and centrifuged at 2700 rpm (408 RCF‐clot) for 12 min. In the experimental groups where L‐PRF was utilized, the membrane was inserted into the osteotomy site prior to implant placement. Six dogs had implants placed in the radius for 3 weeks; and 7 dogs had implants placed in the left radius for 6 weeks and in the right radius for 12 weeks. At the corresponding experimental time points, samples were harvested, and subjected to histological processing for qualitative and quantitative analyses, via bone‐to‐implant contact (BIC) and bone‐area‐fraction occupancy (BAFO). Qualitative analysis demonstrated increased amounts of bone formation around the implant and within the healing chambers over time for all groups. While comparable histological features were observed for both Reg groups (L‐PRF and nL‐PRF), the gap management performed in Wide L‐PRF group resulted in effective gap filling with improved bone growth in close proximity to the implant surface. Quantitative analyses of BIC and BAFO yielded higher values for both variables at 3 weeks for Wide L‐PRF (~38% and ~56% respectively) compared to Wide nL‐PRF (~20% for BIC and BAFO) (p < .03). No statistical differences were detected between Wide groups at 6 and 12 weeks, neither between Reg groups, independent of the association with or without the L‐PRF membrane at all healing times. L‐PRF placed within wide osteotomies, prior to implant placement, resulted in increased early bone formation compared to unfilled wide osteotomies at the early healing time (3 weeks in vivo).

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PRP in Oral and Maxillofacial Surgery and Dental Implants

Halepas

Chen²,

Koch

2022

Platelet Rich Plasma in Medicine

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Does platelet-rich fibrin have a role in osseointegration of immediate implants? A randomized, single-blind, controlled clinical trial

Cited by 41 publications

References 31 publications

Evaluation of Two Different Biomaterials Effect on Immediate Implant Stability and Bone Changes, a Randomized Parallel Group Clinical Trial

Evaluation of Two Different Biomaterials Effect on Immediate Implant Stability and Bone Changes, a Randomized Parallel Group Clinical Trial

Effect of leukocyte‐platelet‐rich fibrin in bone healing around dental implants placed in conventional and wide osteotomy sites: A pre‐clinical study

PRP in Oral and Maxillofacial Surgery and Dental Implants

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