Does positive pressure ventilation increase arginine vasopressin in preterm neonates?

Lambert, H; Baylis, P. H.; McAulay, Judith A; Coulthard, Malcolm

doi:10.1136/fn.78.1.f38

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…Lambert et al [22] reported similar plasma vasopressin levels in ventilated preterm neonates to those in the present study and demonstrated an inverse relationship between systolic blood pressure and plasma AVP concentration. It is demonstrated that the most dominant stimulus for secretion of vasopressin is high serum osmolarity in animal studies [26,27] .…”

Section: Discussionsupporting

confidence: 73%

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Levels of Catecholamines, Arginine Vasopressin and Atrial Natriuretic Peptide in Hypotensive Extremely Low Birth Weight Infants in the First 24 Hours after Birth

Ezaki

Suzuki²,

Kurishima³

et al. 2008

Neonatology

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Background: Extremely low birth weight infants (ELBWI) often suffer from severe hypotension in the early neonatal period. However, few previous studies have ever revealed plasma levels of vasoactive substances which regulate the cardiovascular system in ELBWI. Objective: To study plasma levels of vasoactive substances in ELBWI with hypotension during the first 24 h of life. Methods: 22 ELBWI with hypotension (gestational age 26.4 ± 1.9 weeks; birth weight 751 ± 135 g) were involved in the study. After initial volume therapy, the infants were arbitrarily divided into two groups depending on requirement of dopamine dosage: severe hypotension group (SH; dopamine >10 μg/kg/min, n = 9) and mild hypotension group (MH; dopamine ≤10 μg/kg/min, n = 13). Plasma levels of dopamine, norepinephrine, epinephrine, arginine vasopressin, and atrial natriuretic peptide were measured at admission and at 24 h after birth. Results: Infants in the SH group had higher plasma dopamine than infants in the MH group both at admission (median; range: 14,410; 224–46,770 vs. 7,900; 32–21,220 pg/ml, p < 0.05) and at 24 h (80,920; 494–146,100 vs. 25,680; 10,130–63,180 pg/ml; p < 0.05). The norepinephrine/dopamine ratio (median; range) was lower in the SH group than in the MH group at admission (0.3; 0.0–1.0 vs. 1.1; 0.1–25.1; p < 0.01). Plasma levels of atrial natriuretic peptide or arginine vasopressin were not different between the two groups. Conclusions: ELBWI with SH may have decreased conversion of dopamine to norepinephrine. We speculate that this mechanism may contribute to development of SH in ELBWI.

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Section: Discussionsupporting

confidence: 73%

“…ported to have fluctuations in serum cortisol and AVP concentrations [20][21][22] . On the other hand, preterm infants before 27 weeks are reported to have lower serum cortisol levels compared to adults [23] .…”

Section: Discussionmentioning

confidence: 99%

Levels of Catecholamines, Arginine Vasopressin and Atrial Natriuretic Peptide in Hypotensive Extremely Low Birth Weight Infants in the First 24 Hours after Birth

Ezaki

Suzuki²,

Kurishima³

et al. 2008

Neonatology

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“…In one series [17], comparison of results from three groups of preterm infants demonstrated that those with RDS were unable to excrete the administered fluid, gained weight and developed hyponatraemia. In animal models positive pressure ventilation is also a stimulus for AVP release [18], but the effect of ventilation on AVP levels in the human is debated [3,11,[19][20][21]. In one study [3] continuous sequential urinary arginine vasopressin measurement in 14 preterm ventilated infants demonstrated that AVP levels increased during deterioration of the respiratory illness, mask ventilation and the development of bilateral pneumothoraces or severe intraventricular haemorrhage [3].…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Arginine Vasopressin Levels and Fluid Balance in the Perinatal Period in Infants Who Did and Did Not Develop Chronic Oxygen Dependency

et al. 2000

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Arginine vasopressin (AVP) levels on days 1, 3 and 5 and fluid balance in the perinatal period were assessed in 60 infants, median gestational age 27 weeks (range 24–33). Fluid input and output, urine osmolality and episodes of hyponatraemia were recorded on a daily basis. Forty-one infants subsequently developed chronic lung disease (CLD), they were more immature, of lower birthweight and had higher AVP levels on days 3 and 5 (p < 0.05) than the rest of the cohort. Despite similar levels of fluid input, compared to the non-CLD infants, those who developed CLD had higher urine osmolalities on days 1, 5, 6 and 7 (p < 0.05), but there were not significant differences between the two groups regarding urine output or episodes of hyponatraemia. Logistic regression analysis revealed AVP levels on day 3 were significantly correlated with the duration of oxygen dependency independent of other factors. We conclude elevated AVP levels in the perinatal period are associated with CLD development, but our results suggest they have little functional significance.

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“…[ 1 ] SIADH may be caused by various conditions, such as disorders involving the central nervous system, a variety of malignant tumors, major abdominal or thoracic surgeries, symptomatic HIV infection, and intrathoratic disorders such as infections, positive pressure ventilation, and conditions with a decrease in left atrial pressure. [ 2 ] Also, a large number of drugs have been shown to cause SIADH including chlorpropamide, carbamazepine, oxcarbazepine, SSRIs, and a number of cytotoxic drugs such as vincristine, vinblastine, cisplatin, cyclophosphamide, and melphalan. [ 1 ]…”

Section: Discussionmentioning

confidence: 99%

Hyponatremia associated with unilateral hand weakness and numbness: A case report

et al. 2013

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Context:The key clinical features in this case are to make the diagnosis apical lung cancer (Pancoast tumor) in a patient with brachial plexopathy and to recognize the association between syndrome of inappropriate secretion of antidiuretic hormone (SIADH) as a paraneoplastic syndrome and non-small cell lung cancer (NSCLC).Case Report:We herein describe a rare case of NSCLC presented as pancoast tumor complicated by brachial plexopathy and associated with SIADH as a paraneoplastic phenomena. There were no renal insufficiency, congestive cardiac failure, liver insufficiency, volume depletion, diuretic use, hypoadrenalism, and hypothyroidism in our patient. Furthermore, the findings of serum hyponatraemia and hypo-osmolality associated with an inappropriate high urinary osmolality indicate that the SIADH was present in our patient due to the NSCLC.Conclusion:Our case also emphasizes that early recognition and appropriate applied management may significantly improve symptoms and prevent complications of hyponatremia which may enhance quality of life in patients with paraneoplastic SIADH.

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Does positive pressure ventilation increase arginine vasopressin in preterm neonates?

Cited by 4 publications

References 19 publications

Levels of Catecholamines, Arginine Vasopressin and Atrial Natriuretic Peptide in Hypotensive Extremely Low Birth Weight Infants in the First 24 Hours after Birth

Levels of Catecholamines, Arginine Vasopressin and Atrial Natriuretic Peptide in Hypotensive Extremely Low Birth Weight Infants in the First 24 Hours after Birth

A Comparison of Arginine Vasopressin Levels and Fluid Balance in the Perinatal Period in Infants Who Did and Did Not Develop Chronic Oxygen Dependency

Hyponatremia associated with unilateral hand weakness and numbness: A case report

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