Does Pre-Implantation Genetic Testing for Aneuploidy Optimise the Reproductive Outcomes Inwomen With Idiopathic Recurrent Pregnancy Loss?

Mantravadi, Krishna; Mathew, Sherin; Soorve, Shivanand; Rao, Durga Gedela; Karunakaran, Sandeep

doi:10.1016/j.fertnstert.2020.08.1267

Cited by 4 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1, and were excluded from the study. The most common reasons for exclusion were that the article concerned a conference abstract [13][14][15][16][17][18][19], absence of relevant inclusion criteria , absence of published study results [50,51], absence of a control group [52][53][54][55][56][57][58][59][60][61][62][63], and some studies [64][65][66][67][68] were review articles.…”

Section: Resultsmentioning

confidence: 99%

Preimplantation genetic testing for aneuploidy in patients of different age: a systematic review and meta-analysis

Adamyan,

Pivazyan,

Obosyan

et al. 2024

Obstet Gynecol Sci

View full text Add to dashboard Cite

This study aimed to summarize the current knowledge on the benefits of in vitro fertilization/intracytoplasmic sperm injection with preimplantation genetic testing for aneuploidy (PGT-A) and to discuss the role of PGT-A in patients of different ages undergoing assisted reproduction. A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 checklist.Registration number: CRD42022354697. Studies were identified by searching the PubMed, Cochrane Library, Google Scholar, Scopus, Embase, and ClinicalTrials databases. Seven meta-analyses were performed with additional stratification of age and prognosis of the women studied. Clinical pregnancy rate per embryo transfer in patients aged >35 years was higher in the PGT-A group (P=0.0002) than in controls. Live birth rate (LBR) per embryo transfer in women 35 years old or younger (P=0.002) was higher in the PGT-A group. The LBR per patient in women aged >35 years was higher in the PGT-A group (P=0.004). The effects of PGT-A on LBR in patients with poor prognosis showed a statistically significant increase (P=0.003). There was no significant difference in the rate between the two groups.PGT-A is effective and can be recommended for patients aged >35 years undergoing assisted reproduction to improve their reproductive outcomes. Moreover, our study showed the possible benefits of PGT-A in patients with a poor prognosis. Overall, our findings suggest that PGT-A is a valuable tool for improving the reproductive outcomes of assisted reproductive procedures in older women and those with a history of pregnancy complications.

show abstract

Section: Resultsmentioning

confidence: 99%

Preimplantation genetic testing for aneuploidy in patients of different age: a systematic review and meta-analysis

Adamyan,

Pivazyan,

Obosyan

et al. 2024

Obstet Gynecol Sci

View full text Add to dashboard Cite

show abstract

“…Furthermore, they should be recommended to have prenatal diagnosis during the pregnancy period ( 27 , 35 ). Their offspring should also have postnatal follow-up ( 25 ). In the future, the reproductive outcomes of RRF may be furtherly improved by artificial intelligence which could play a role in the following aspects: ultrasound monitoring of folliculogenesis, endometrial receptivity, embryo selection based on quality and viability, and prediction of post implantation embryo development, etc.…”

Section: Discussionmentioning

confidence: 99%

“…In the same year, Lei et al (30) reported that RPL sufferers using PGT-A (n = 212) had acquired higher LBRs per cycle start (26.6 vs. 15.4%, p = 0.0004) and transfer (44.9 vs. 25.1%, p < 0.0001), and lower MR (15.7 vs. 34.6%, p = 0.0007) than those not using PGT-A (n = 294). In 2020, retrospective study of Mantravadi et al (25) reported that the MR (9.68 vs. 23.33%, p = 0.0610) was lower in patients with idiopathic RPL using PGT-A (n = 82) than those not using PGT-A (n = 30), although the LBR and take home baby rates were not significantly different. Also in 2020, Sato et al (20) made a multi-center prospective study which revealed that no significant differences were observed in the LBR and the MR in RPL sufferers given or not given PGT-A.…”

Section: The Aneuploidy Rate Increased In Rrf Especially In Patients ...mentioning

confidence: 96%

Preimplantation genetic testing for aneuploidy optimizes reproductive outcomes in recurrent reproductive failure: a systematic review

Mei,

Lin,

Chen

et al. 2024

Front. Med.

View full text Add to dashboard Cite

IntroductionRecurrent reproductive failure (RRF) is a common pregnancy complication, imposing great physical, emotional and financial burden for the suffered couples. The leading cause of RRF is believed to be aneuploid embryo, which could be solved by preimplantation genetic testing for aneuploidy (PGT-A) in theory. With molecular genetic development, PGT-A based on comprehensive chromosomal screening (CCS) procedures and blastocyst biopsy is widely applied in clinical practice. However, its effects in RRF were not defined yet.MethodsA systematic bibliographical search was conducted without temporal limits up to June, 2023. Studies about the effects of PGT-A based on CCS procedures and blastocyst biopsy in RRF were included.ResultsTwenty studies about the effects of PGT-A based on CCS procedures and blastocyst biopsy in RRF were included. It revealed that PGT-A could optimise the reproductive outcomes of RRF sufferers, especially in those with advanced age. However, in patients with multiple occurrences of pregnancy losses, the benefits of PGT-A were limited.DiscussionMore randomized controlled trials with large sample size are required to evaluate the benefits of PGT-A in RRF sufferers and identify which population would benefit the most.

show abstract

Preimplantation genetic testing for aneuploidy in unexplained recurrent pregnancy loss: a systematic review and meta-analysis

Mumusoglu,

Telek,

Ata

2025

Fertility and Sterility

View full text Add to dashboard Cite

Does Pre-Implantation Genetic Testing for Aneuploidy Optimise the Reproductive Outcomes Inwomen With Idiopathic Recurrent Pregnancy Loss?

Cited by 4 publications

References 0 publications

Preimplantation genetic testing for aneuploidy in patients of different age: a systematic review and meta-analysis

Preimplantation genetic testing for aneuploidy in patients of different age: a systematic review and meta-analysis

Preimplantation genetic testing for aneuploidy optimizes reproductive outcomes in recurrent reproductive failure: a systematic review

Preimplantation genetic testing for aneuploidy in unexplained recurrent pregnancy loss: a systematic review and meta-analysis

Contact Info

Product

Resources

About