Does pregnancy affects pharmacokinetics of intravenous ketorolac?

Determination of Racemic Ketorolac, Ketorolac Enantiomers and Their Metabolites in Human Plasma and Urine by LC–UV, Applied in Clinical Study During and After Pregnancy

“…racemic ketorolac glucuronide in urine was also quantified by hydrolysis of samples. Data on racemic ketorolac in young women including women at delivery and in postpartum with significant differences in disposition in the same group of women at delivery and 4-5 months postpartum have recently been reported by our group [4,[13][14][15]. Data on enantiomer-specific disposition are of relevance and in the present study, we would like to focus on pharmacokinetics' differences between ketorolac enantiomers in hereby mentioned group of young women.…”

“…Physiological changes in pregnancy and postpartum, including changes in hepatic and renal functions likely affect ketorolac disposition [4,5]. Despite the limited data on ketorolac pharmacokinetics in those women, it is frequently used as analgesic in this population [6][7][8][9][10][11][12], as part of a multimodal post-caesarean analgesia [4,[13][14][15].…”