Does prematurity affect platelet indices?

Wasiluk, Alicja; Osada, Joanna; Dąbrowska, Milena; Szczepański, Marek; Jasińska, Elwira

doi:10.2478/v10039-009-0034-3

Cited by 19 publications

(14 citation statements)

References 10 publications

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“…In the current literature, there are several studies demonstrating a significant association between elevated MPV and PDW values and severe inflammatory processes. Wasiluk et al [34] demonstrated higher MPV and lower PDW values in term infants when compared with preterm infants. Dizdar et al [15] have reported that infants with increased PDW values have a higher risk of patency of ductus arteriosus.…”

Section: Discussionmentioning

confidence: 97%

Is there a relationship between platelet parameters and patency of ductus arteriosus in preterm infants?

Olukman

Özdemir²,

Karadeniz³

et al. 2017

Blood Coagulation &Amp; Fibrinolysis

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Postnatal closure of the ductus arteriosus is a complicated two-phase process involving functional and structural changes. So far, the precise mechanisms regulating this process are not fully understood. A growing body of evidence from recent studies suggests that platelets play a key role in inflammatory processes including ductal closure via interaction with endothelial cells. The aim of this study is to assess whether a relationship exists between the occurrence and/or closure of hemodynamically significant ductus arteriosus (HSDA) and platelet parameters (platelet count, circulating platelet mass, mean platelet volume, platelet distribution width) in preterm newborns. This single-center, retrospective study included 824 premature infants between 24 and 34 gestational weeks, evaluated by echocardiography at postnatal 72-96 h. Infants with and without HSDA (n = 208 vs. n = 616) were compared in terms of platelet parameters recorded within the first 3 days of life. Oral or intravenous ibuprofen was commenced for medical treatment, and echocardiography was repeated 24 h thereafter to determine ductal closure. No statistically significant difference could be demonstrated between the groups in terms of baseline platelet parameters. HSDA was independently associated with early-onset neonatal sepsis. Thrombocytopenia, low circulating platelet mass, high platelet distribution width, or high mean platelet volume could not be demonstrated as a risk factor for HSDA. None of the platelet parameters had an influence on ductal closure after medical treatment. Unlike most reports in the literature, presence of HSDA was not associated with any platelet parameter in our study. We could not demonstrate an association between any platelet parameter and either persistence or closure after medical treatment.

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Section: Discussionmentioning

confidence: 97%

Is there a relationship between platelet parameters and patency of ductus arteriosus in preterm infants?

Olukman

Özdemir²,

Karadeniz³

et al. 2017

Blood Coagulation &Amp; Fibrinolysis

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“…1,3 However, MPV has been poorly investigated in preterm infants. A few studies compared the MPV of term and preterm infants and gave contradictory results, although MPV was found similar 4,5 or lower 6 in preterm than in term infants. Moreover, Gioia et al reported that low MPV is associated with more frequent oxygen therapy or need for mechanical ventilation at 48 hours of life and pH <7.20 at umbilical blood gas analysis in preterm infants from mothers with abnormal blood flow velocity in uterine arteries.…”

mentioning

confidence: 98%

Mean Platelet Volume and Risk of Bronchopulmonary Dysplasia and Intraventricular Hemorrhage in Extremely Preterm Infants

et al. 2011

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The possible correlation between the mean platelet volume (MPV) and the occurrence of bronchopulmonary dysplasia (BPD) and intraventricular hemorrhage (IVH) in a cohort of preterm infants was assessed. We studied infants with gestational age <30 weeks. Enrolled infants were divided into BPD and no-BPD groups and IVH and no-IVH groups. MPV was evaluated at birth and at 24 to 48 hours of life. MPV measured at birth was similar in BPD and no-BPD groups, but at 24 to 48 hours of life was higher in the BPD than in the no-BPD group (11.1 ± 0.9 versus 10.8 ± 0.9 fL, P = 0.033) and multivariate analysis demonstrated that MPV >11 fL increases (relative risk 1.40, 95% confidence interval 1.08 to 1.80) the risk of developing BPD. MPV was similar in infants with or without IVH. We concluded that high MPV in the first days of life is a risk factor for the development of BPD in extremely preterm infants. This might be because high MPV could favor inflammatory and oxidative lung damage. On the contrary, our data indicate that MPV is not associated with the development of IVH in our population.

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“…Studies by Wasiluk et al demonstrated that platelet indices are altered by prematurity and GA. [118] Although, platelet changes in premature neonates have been already contributed to GA and birth weight, [19] these authors concluded that decreased platelet count and increased distribution width occurs in relation with low GA and dysfunction of placenta. Further study also confirmed these findings with more emphasis on the effect of intrauterine growth retardation on thrombopoiesis and subsequent platelet impairments.…”

Section: Discussionmentioning

confidence: 99%

Hemostatic profile in healthy premature neonates; Does birth weight affect the coagulation profile?

et al. 2014

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Context:There are limited studies assessing the neonatal hemostatic factors in relation to birth weight.Aims:This study aims to compare the coagulation factors between three groups of neonates with different birth weight for gestational age (GA).Settings and Design:In a cross-sectional study, 74 healthy premature neonates were involved.Subjects and Methods:Serum prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ratio (INR), thrombin clotting time (TT), and levels of fibrinogen, anti-thrombin III, protein S and protein C were measured. Neonates were classified into three groups according to birth weight, including small, appropriate and large for gestational age (SGA, AGA, and LGA).Statistical Analysis Used:Statistical analysis was performed using SPSS software.Results:There was a significant difference in the levels of protein S (P < 0.001), protein C (P = 0.004), and values of APTT (P = 0.01) between three groups. Other coagulation factors however, did not represent a significant pattern (P > 0.05). Protein S concentration, directly (B = 0.78, P < 0.001), and APTT, inversely (B = −0.29, P = 0.03), associated with birth weight after adjustment for GA and sex.Conclusions:Despite the decrease in APTT from SGA to AGA, and LGA neonates, levels of protein S increases directly with birth weight. However, no other coagulation factors revealed an explainable pattern in relation to the state of SGA, AGA, or LGA.

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Does prematurity affect platelet indices?

Cited by 19 publications

References 10 publications

Is there a relationship between platelet parameters and patency of ductus arteriosus in preterm infants?

Is there a relationship between platelet parameters and patency of ductus arteriosus in preterm infants?

Mean Platelet Volume and Risk of Bronchopulmonary Dysplasia and Intraventricular Hemorrhage in Extremely Preterm Infants

Hemostatic profile in healthy premature neonates; Does birth weight affect the coagulation profile?

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