Does prematurity affect thrombocytopoiesis?

Wasiluk, Alicja; Mantur, M; Kemona-Chetnik, I; Szczepański, Marek; J, Warda; Bochenko-Łuczyńska, Joanna

doi:10.1080/09537100701206816

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…Higher PV levels observed in preterm newborns are due to the increased status of activated platelets in the early postnatal weeks, but the inflammatory and thrombotic conditions may vary in function of disease grade. Clinical studies showed that the clinicopathological aspects are associated with increased platelet volume [ 9 , 10 ]. Authors presented that they found in RDS+ newborns higher PV levels, which means that PV could be a predictive biomarker for other encountered diseases in preterm newborns.…”

Section: Discussionmentioning

confidence: 99%

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Changes in Platelet Function in Preterm Newborns with Prematurity Related Morbidities

et al. 2022

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Platelet indices represent useful biomarkers to express the thromboembolic status, inflammatory response, and oxidative stress in preterm newborns. Our study presented platelet count and function changes in prematurity-related morbidities such as respiratory distress syndrome, intraventricular bleeding, and anemia of prematurity in preterm newborn cases reported to healthy full-term newborns by flow cytometry and hematological methods. The platelet volume represents the average size of platelets in the blood samples, showing the significantly increased values in preterm newborns compared with healthy full-term newborns due to increasing activated platelet production. Flow cytometric analysis of immature platelet fractions (IPF) made using thiazole orange staining to detect their mRNA content and a glycoprotein (anti-GPIIIa) antibody for platelet gating. CD61-TO expression from premature newborns was significantly lower compared to healthy full-term neonates. Preterm newborn cases with respiratory distress syndrome and a need for respiratory support (RDS+) were characterized by a significantly increased platelet volume and a decreased immature platelet fraction reported in RDS− cases. Evaluating the platelet function in the newborn is difficult because the laboratory methodologies work with small quantities of newborn blood samples. The immature platelet fractions and platelet volume promise to be diagnostic biomarkers for diseases.

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Section: Discussionmentioning

confidence: 99%

“…The platelet count is dependent on gestational age, being 150–450 × 10 3 /µL from 22 weeks of gestation age [ 9 , 10 ]. The immature platelets fraction percent (IPF) is increased in healthy newborn circulation [ 11 ], but the platelet volume (PV) tends to be comparable to adults.…”

Section: Introductionmentioning

confidence: 99%

Changes in Platelet Function in Preterm Newborns with Prematurity Related Morbidities

et al. 2022

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“…Platelet count is dependent on gestational age, increasing during fetal life, but usually reaches the expected adult range of 150,000 to 450,000/µL [58] from about 22 weeks of gestation [59]. The percentage of reticulated platelets, an indication of newly produced platelets, is higher in the newborn circulation [60], while the mean platelet volume (MPV), a measure of platelet size, tends to be comparable to adults.…”

Section: Newborn Plateletsmentioning

confidence: 99%

Platelets in the Newborn

Esiaba¹,

Mousselli²,

Faison³

et al. 2019

Neonatal Medicine

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Platelets were first described in the mid-nineteenth century. Since then, their roles were identified in hemostasis and thrombosis, inflammation, leukocyte interactions, angiogenesis, and cancer growth. But there is little information about such platelet functions in the newborn. Several studies highlighted some platelet differences between newborns and adults. Yet, in spite of these differences, healthy newborns appear to be adequately protected. A number of factors, however, were reported to negatively affect neonatal platelets. These include maternal hypertensive disorders or infections, neonatal asphyxia or respiratory distress, therapies such as ampicillin or indomethacin, and treatment modalities such as ventilators, nitric oxide, or extracorporeal membrane oxygenation (ECMO). Their effects on newborn platelets are usually transitory, lasting from several hours to a few days or weeks. If these effects are well characterized, they could serve as reporters for diagnosis and monitoring during therapy. Careful studies of neonatal platelets are needed to improve the understanding of basic physiology and pathophysiology in this cohort and to identify possible targets for intervention and therapy.

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