Does Preoperative Fine Needle Aspiration-Biopsy Produce Tumor Recurrence in Patients Following Liver Transplantation for Hepatocellular Carcinoma?

Pérez-Saborido, B.; Díaz, Juan Carlos Meneu; Galanes, Santos Jiménez de los; Segurola, Carmelo Loinaz; Usera, M. Abradelo de; Garrido, M.; Elola-Olaso, A. Moreno; Sanz, R Gómez; Romero, Carlos Jiménez; García, Ignacio; González, Enrique Moreno

doi:10.1016/j.transproceed.2005.09.169

Cited by 55 publications

(34 citation statements)

References 16 publications

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“…Diagnosis can be made purely by radiology. Saborido et al [27] reported a higher recurrence rate among patients who underwent tumor biopsy before liver transplantation. Currently, a pre-transplant tissue diagnosis is not required in cirrhotic patients that have the classic imaging findings for HCC [12,28] .…”

Section: Diagnosismentioning

confidence: 99%

Hepatocellular carcinoma: A comprehensive review

Waller

Deshpande

Pyrsopoulos

2015

WJH

176

123

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chronic hepatitis B and C infections are most commonly afflicted. Different therapeutic options, including liver resection, transplantation, systemic and local therapy, must be tailored to each patient. Liver transplantation offers leading results to achieve a cure. The Milan criteria is acknowledged as the model to classify the individuals that meet requirements to undergo transplantation. Mean survival remains suboptimal because of long waiting times and limited donor organ resources. Recent debates involve expansion of these criteria to create options for patients with HCC to increase overall survival.

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Section: Diagnosismentioning

confidence: 99%

Hepatocellular carcinoma: A comprehensive review

Waller

Deshpande

Pyrsopoulos

2015

WJH

176

123

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“…However, preoperative biopsy may cause tumor seeding and bleeding. Saborido et al [16] reported that a significantly higher chance of HCC recurrence came with fine-needle aspiration biopsy before LT (31.8% vs 5.9%, P = 0.003). In Hong Kong, contrast computed tomography (CT) [17] is used for tumor staging.…”

Section: Risk Factors For Hcc Recurrencementioning

confidence: 99%

Management of recurrent hepatocellular carcinoma after liver transplant

Chok¹

2015

WJH

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Hepatocellular carcinoma (HCC) is the leading cause of deaths in patients with hepatitis B or C, and its incidence has increased considerably over the past decade and is still on the rise. Liver transplantation (LT) provides the best chance of cure for patients with HCC and liver cirrhosis. With the implementation of the MELD exception system for patients with HCC waitlisted for LT, the number of recipients of LT is increasing, so is the number of patients who have recurrence of HCC after LT. Treatments for intrahepatic recurrence after transplantation and after other kinds of surgery are more or less the same, but long-term cure of posttransplant recurrence is rarely seen as it is a "systemic" disease. Nonetheless, surgical resection has been shown to be effective in prolonging patient survival despite the technical difficulty in resecting graft livers. Besides surgical resection, different kinds of treatment are also in use, including transarterial chemoembolization, radiofrequency ablation, highintensity focused ultrasound ablation, and stereotactic body radiation therapy. Targeted therapy and modulation of immunosuppressants are also adopted to treat the deadly disease.

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“…In addition, it can cause bleeding in cirrhotic patients. 37,38 Furthermore, not only the presence of microvascular invasion, but also dominant differentiation grade of tumors may not be reliably assessed before LT in spite of invasive biopsy procedure. 39,40 Hence, biomarkers strongly correlated with these histopathologic features may be actually more helpful in patient selection than preoperative biopsy.…”

Section: Histopathological Featuresmentioning

confidence: 99%

Liver Transplantation for Advanced Hepatocellular Carcinoma

Lee

Suh

2010

Korean J Transplant

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There has been ongoing debate that the Milan criteria may be too strict that a significant number of patients who could benefit from liver transplantation (LT) might have been excluded. Based on this idea, various studies have been conducted to further expand the Milan criteria and give more HCC patients a chance of cure. In deceased donor LT (DDLT) setting, expansion of the criteria is relatively tempered because the results of LT for HCC should be comparable to those of patients with non-malignant indications. On the other hand, in living donor LT (LDLT) situation, liver grafts are not public resources. The acceptable target outcomes for LDLT might be much lower than those for DDLT. Patients with biologically favorable tumors might have excellent survivals after LT despite morphological advanced HCCs. Therefore, the significance and utility of biological tumor parameters for selecting suitable LT candidates have been increased to predict HCC recurrence after LT. Although there is no consensus regarding the use of prognostic biomarkers in LT selection criteria for HCC, the combination of conventional morphological parameters and new promising biomarkers could help us refine and expand the LT criteria for HCC in the near future. developed the expanded criteria of their own. Some of them use biological parameters as well as conventional morphological factors to select patients suitable to LT. 5 The increasing importance of biologic parameters is leading to a paradigm shift in LT patient selection criteria. This article aims at reviewing new strategies proposed to perform LT for more advanced HCC.

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Does Preoperative Fine Needle Aspiration-Biopsy Produce Tumor Recurrence in Patients Following Liver Transplantation for Hepatocellular Carcinoma?

Cited by 55 publications

References 16 publications

Hepatocellular carcinoma: A comprehensive review

Hepatocellular carcinoma: A comprehensive review

Management of recurrent hepatocellular carcinoma after liver transplant

Liver Transplantation for Advanced Hepatocellular Carcinoma

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