Does propofol or caffeic acid phenethyl ester prevent lung injury after hindlimb ischaemia-reperfusion in ventilated rats?

Akyol, Ahmet; Ulusoy, Hülya; İmamoğlu, Mustafa; Çay, Ali; Yuluğ, Esin; Alver, Ahmet; Ertürk, Engin; Koşucu, Müge; Beşir, Ahmet; Akyol, Abdurrezak; Özen, İbrahim

doi:10.1016/j.injury.2006.01.004

Cited by 20 publications

(14 citation statements)

References 22 publications

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“…Our results suggest that CAPE can also be used to improve lung function after acute severe pancreatitis. CAPE treatment has been shown to protect against lung injury caused by increased oxidative stress and neutrophil accumulation after hindlimb ischemia-reperfusion [35]. CAPE treatment also decreased the inflammatory responses induced by thoracic irradiation without causing toxicity in normal lung tissue [36].…”

Section: Discussionmentioning

confidence: 99%

Effects of Caffeic Acid Phenethyl Ester on Pancreatitis in Rats

Türkyılmaz

Alhan

Erçín

et al. 2008

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Effects of Caffeic Acid Phenethyl Ester on Pancreatitis in Rats

Türkyılmaz

Alhan

Erçín

et al. 2008

Journal of Surgical Research

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“…Administration of CAPE completely blocks both the production of ROS in human neutrophils and the xanthine-xanthine oxidase system [54]. The antioxidant effects of CAPE have been investigated in many studies [25,55,56].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Caffeic Acid Phenethyl Ester (CAPE) on TNBS-induced Colitis in Ovariectomized Rats

Serter

Ergin

et al. 2007

Dig Dis Sci

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“…Our results suggest that CAPE can also be used to improve lung function after severe sepsis. CAPE treatment has been shown to protect against lung injury caused by increased oxidative stress and neutrophil accumulation after hindlimb ischemia-reperfusion [35]. CAPE treatment also decreased the inflammatory responses induced by thoracic irradiation without causing toxicity in normal lung tissue [36].…”

Section: Discussionmentioning

confidence: 99%

Effects of Caffeic Acid Phenethyl Ester (CAPE) on Sepsis in Rats

et al. 2008

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Sepsis is still a major cause of the high mortality rate in the intensive care unit. Many studies have been published about the severity of sepsis, but the cause of mortality in sepsis and multiorgan failure is still obscure. This study investigated the effects of caffeic acid phenethyl ester (CAPE) particularly on the inflammatory and related histopathological changes in the lung, liver and kidney in an experimental sepsis model. Forty Sprague Dawley rats were used in this study, and were divided into four groups of ten rats each, as follows: Group I was given intraperitoneal saline infusion treatment. Group II was given intraperitoneal CAPE infusion treatment. Sepsis was induced in the animals in Group III (sepsis with saline infusion), while Group IV rats underwent induced sepsis plus CAPE infusion treatment (sepsis with CAPE infusion). Sampling was performed 48 h after treatment. The induction of sepsis resulted in a significant increase in serum glucose, leukocytes, urea, creatinine, LDH levels in BAL, plasma MDA, AST and ALT levels in the sepsis + saline group. The use of CAPE significantly decreased these parameters. Histopathological examination revealed less congestion, portal inflammation, and focal necrosis of the liver, and less congestion, edema, and emphysematous and inflammatory changes in the lung in the sepsis + CAPE group than in the other groups. These results support that CAPE may be used for the treatment of organ failure during sepsis.

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Does propofol or caffeic acid phenethyl ester prevent lung injury after hindlimb ischaemia-reperfusion in ventilated rats?

Cited by 20 publications

References 22 publications

Effects of Caffeic Acid Phenethyl Ester on Pancreatitis in Rats

Effects of Caffeic Acid Phenethyl Ester on Pancreatitis in Rats

The Effects of Caffeic Acid Phenethyl Ester (CAPE) on TNBS-induced Colitis in Ovariectomized Rats

Effects of Caffeic Acid Phenethyl Ester (CAPE) on Sepsis in Rats

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