Does propolis have any effect on rheumatoid arthritis? A review study

Nattagh‐Eshtivani, Elyas; Pahlavani, Naseh; Ranjbar, Golnaz; Navashenaq, Jamshid Gholizadeh; Salehi‐Sahlabadi, Ammar; Mahmudiono, Trias; Shalaby, Mohammed Nader; Jokar, Mohammad Hassan; Nematy, Mohsen; Barghchi, Hanieh; Havakhah, Shahrzad; Maddahi, Mona; Rashidmayvan, Mohammad; Khosravi, Maryam

doi:10.1002/fsn3.2684

Cited by 28 publications

(24 citation statements)

References 227 publications

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“…Identifying modifiable CVD risk factors is of great significance in terms of setting up primary prevention strategies. Unhealthy diet has been considered a key modifiable risk factor for many chronic diseases [4][5][6][7]. Lifestyle changes, especially modification in dietary pattern, are recommended as part of prevention and control strategies for metabolic disorders such as dyslipidemia and insulin resistance [8].…”

Section: Introductionmentioning

confidence: 99%

Association between spicy foods consumption and cardiovascular disease risk factors: Guangzhou Biobank Cohort Study

Zhang

Jin

et al. 2022

BMC Public Health

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Background Evidence regarding the association of spicy foods intake with cardiovascular disease (CVD) risk factors was less clear, especially in those with diabetes. We hereby examined the association of spicy foods intake with CVD risk factors in older Chinese. Methods Thirty thousand three hundred twenty-five participants (72.34% women) aged 50+ years were recruited in the Guangzhou Biobank Cohort Study from 2003 to 2008. Information of spicy foods intake and disease history was collected by face-to-face interview. CVD risk factors were measured and treated as continuous variables. Diabetes was defined by a fasting plasma glucose (FPG) ≥7.0 mmol/L and/or self-reported physician-diagnosed diabetes. Results Of 30,325 participants, 12.9% consumed spicy foods regularly. After adjusting for multiple confounders, participants who consumed spicy foods of 5–7 days/week, versus none, had higher body mass index (1.18, 95% confidence interval (CI) 0.95 to 1.42 kg/m2), waist circumference (2.80, 95% CI 2.18–3.41 cm), waist-to-hip ratio (0.010, 95% CI 0.006 to 0.015), systolic blood pressure (2.44, 95% CI 0.92 to 3.97 mmHg), diastolic blood pressure (1.94, 95% CI 1.14 to 2.73 mmHg), FPG (0.310, 95% CI 0.188 to 0.432 mmol/L), triglycerides (0.185, 95% CI 0.096 to 0.273 mmol/L), and lower high-`density lipoprotein cholesterol (− 0.040, 95% CI − 0.069 to − 0.012 mmol/L). Similar results were found for the associations of spicy foods strength with CVD risk factors. The results attenuated slightly but not substantially across diabetes groups. Conclusions Our study showed that higher frequency and strength of spicy foods intake were associated with unfavorable cardiovascular disease risk profile in older people, and such associations did not vary by diabetes status. Whether the results were causal needs to be determined in further studies.

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Section: Introductionmentioning

confidence: 99%

Association between spicy foods consumption and cardiovascular disease risk factors: Guangzhou Biobank Cohort Study

Zhang

Jin

et al. 2022

BMC Public Health

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Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 79%

“…The anti-inflammatory effects of propolis have been confirmed by numerous studies in the literature [ 70 , 71 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 ]. Several studies have shown that propolis (as an aqueous or ethanol preparation) can act as a strong anti-inflammatory agent against acute and chronic inflammations [ 70 , 71 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 ]. The efficacy of aqueous extract of propolis (WSDP) was confirmed in an acute model of inflammation (paw edema induced by PGE2) and a chronic model of inflammation (arthritis induced by formaldehyde) [ 130 ].…”

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 79%

“…EEP and selected flavone derivatives (chrysin, galangin, kaempferol and quercetin) exerts its inhibitory effect on the IL-1beta and iNOS gene expression in J774A.1 macrophages at the transcriptional level. Published studies [ 131 , 132 ] confirmed the efficacy of propolis in a randomized clinical trial in patients with rheumatoid arthritis; propolis had a positive effect on inflammatory biomarkers, oxidative stress status, and clinical symptoms of RA patients. However, Matsumoto et al [ 133 ] showed that Brazilian propolis had no effects on disease activity in patients with RA.…”

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 95%

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Allergic Inflammation: Effect of Propolis and Its Flavonoids

Oršolić

2022

Molecules

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The incidence of allergic diseases and their complications are increasing worldwide. Today, people increasingly use natural products, which has been termed a “return to nature”. Natural products with healing properties, especially those obtained from plants and bees, have been used in the prevention and treatment of numerous chronic diseases, including allergy and/or inflammation. Propolis is a multi-component resin rich in flavonoids, collected and transformed by honeybees from buds and plant wounds for the construction and adaptation of their nests. This article describes the current views regarding the possible mechanisms and multiple benefits of flavonoids in combating allergy and allergy-related complications. These benefits arise from flavonoid anti-allergic, anti-inflammatory, antioxidative, and wound healing activities and their effects on microbe-immune system interactions in developing host responses to different allergens. Finally, this article presents various aspects of allergy pathobiology and possible molecular approaches in their treatment. Possible mechanisms regarding the antiallergic action of propolis on the microbiota of the digestive and respiratory tracts and skin diseases as a method to selectively remove allergenic molecules by the process of bacterial biotransformation are also reported.

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“…RA affects approximatley 1% of the world's population and is more common in women than men (McInnes & Schett, 2017). Immune cells of T, B lymphocytes, and macrophages are involved in the pathophysiology of RA (Nattagh‐Eshtivani et al, 2022). These cells cause oxidative stress, systemic and localized inflammation through the overproduction of inflammatory cytokines (Cooles & Isaacs, 2011; Quiñonez‐Flores et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The effect of propolis supplementation on cardiovascular risk factors in women with rheumatoid arthritis: A double‐blind, placebo, controlled randomized clinical trial

Maddahi,

Nattagh‐Eshtivani,

Jokar

et al. 2023

Phytotherapy Research

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Propolis has gained popularity in recent years because of its beneficial properties, which make it a possible preventative and therapeutic agent as well as a valuable food and cosmetic ingredient. The objective of this study was to evaluate the effects of propolis supplementation on cardiovascular risk factors in women with rheumatoid arthritis. This randomized, double‐blind, placebo‐controlled clinical trial was performed among 48 patients diagnosed with rheumatoid arthritis. Subjects were randomly assigned to placebo and intervention groups, supplemented with 1000 mg/day of propolis for 12 weeks. Cardiovascular risk factors including, high‐sensitivity C‐reactive protein (hs‐CRP), monocyte chemoattractant protein (MCP‐1), Nitric oxide, blood pressure, and lipid profile were assessed pre‐and post‐intervention. The atherogenic index of plasma value, as well as total cholesterol/high‐density lipoprotein cholesterol (HDL‐C), triglyceride/HDL‐C, and non‐HDL‐C/HDL‐C ratios, were significantly reduced in the intervention group, compared with the placebo group post‐intervention (p < 0.05). Moreover, there was a significant reduction in the serum level of hs‐CRP in the intervention group when compared with the placebo group (p = 0.001). Furthermore, propolis supplementation could marginally reduce MCP‐1 (p = 0.051). These data indicate that propolis supplementation may be a promising treatment strategy for cardiovascular complications among rheumatoid arthritis patients.

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Does propolis have any effect on rheumatoid arthritis? A review study

Cited by 28 publications

References 227 publications

Association between spicy foods consumption and cardiovascular disease risk factors: Guangzhou Biobank Cohort Study

Association between spicy foods consumption and cardiovascular disease risk factors: Guangzhou Biobank Cohort Study

Allergic Inflammation: Effect of Propolis and Its Flavonoids

The effect of propolis supplementation on cardiovascular risk factors in women with rheumatoid arthritis: A double‐blind, placebo, controlled randomized clinical trial

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