Does Propolis Help to Maintain Oral Health?

Więckiewicz, Włodzimierz; Miernik, Marta; Więckiewicz, Mieszko; Morawiec, Tadeusz

doi:10.1155/2013/351062

Cited by 58 publications

(71 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Greater scientific knowledge of the chemical composition of various types of propolis has helped envision their potential use and application in dental practice. 8,9,26,27 Previous studies have reported the strong antimicrobial activity of propolis against several bacteria of the oral m icrobiome, i ncludi ng S. mutans. 1,2,28,29,30,31 As confirmed in our study, propolis and some of its isolated compounds, such as apigenin and tt-farnesol, 11 have been found to display a major effect on microbial virulence (e.g., polysaccharide production and acid tolerance), rather than affecting unspecific or specific microbiome viability, considered a highly desirable quality.…”

Section: Discussionmentioning

confidence: 99%

The anti-caries activity and toxicity of an experimental propolis-containing varnish

et al. 2017

View full text Add to dashboard Cite

Abstract:We investigated the anti-caries effects of an experimental propolis varnish in vivo, and further tested its toxicity against fibroblasts. Fifty-six SPF female Wistar rats were infected with Streptococcus mutans UA159 (SM) and allocated into four groups (n = 14/group): G1, propolis varnish (15%/PV); G2, chitosan varnish (CV/vehicle); G3, gold standard (GS/Duraphat ® ); and G4, untreated. The animals received a single varnish application on their molars and were submitted to a high cariogenic challenge (Diet-2000, 56% sucrose, and 5% sucrose-added water, ad libitum) for 4 weeks. Total cultivable microbiota and SM were counted, and smooth-surface and sulcal caries were scored. PV, CV and GS cytotoxic effects were tested against fibroblasts. The data were analyzed using ANOVA with the TukeyKramer test (p ≤ 0.05). Total microbiota and SM counts did not differ among the treatments (p = 0.78), or in relation to the untreated group (p = 0.52). PV reduced development of smooth-surface enamel caries compared with the untreated group (p = 0.0018), with no significant difference from GS (p = 0.92); however, the PV effects were no longer observed when the dentin was affected. Neither PV nor GS prevented enamel sulcal lesion onset, but GS significantly reduced the severity of dentinal sulcal lesions (p < 0.0001). No significant difference was observed in fibroblast viability between PV and GS (p < 0.0001).In conclusion, PV prevented smooth-surface enamel caries and showed low cell toxicity. Nevertheless, due to the high cariogenic challenge, its effects were not sustained throughout the experiment. Further studies are encouraged to establish a protocol to sustain the long-term anticaries activity of PV in the oral cavity.

show abstract

Section: Discussionmentioning

confidence: 99%

The anti-caries activity and toxicity of an experimental propolis-containing varnish

et al. 2017

View full text Add to dashboard Cite

show abstract

“…These compounds are produced by bees from bee secretions, beeswax, plant exudates, and other plant parts collected from the surrounding flora (Bankova, 2005;Scazzocchio et al, 2006;Wiȩckiewicz et al, 2013). Propolis contains a variety of compounds, some of which are terpenes, flavonoids and other phenolics (Marcucci, 1995;Bankova et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Literature indicates that propolis is associated with a number of important biological activities including antimicrobial, antioxidant, anticancer, hepatoprotective, anti-inflammatory, immunostimulant, anticariogenic, antiprotozoan, allergenic, antibrowning, antidiabetic and antitumour activities (Ophori et al, 2010;Siripatrawan et al, 2013;Wagh, 2013;Wiȩckiewicz et al, 2013;Wojtyczka et al, 2013a, b;Omar et al, 2016). Furthermore propolis has been reported to exhibit synergism with a number of antibiotics against various bacteria species (Stepanović et al, 2003;Fernandes Júnior et al, 2005;Scazzocchio et al, 2006) and to be active against methicillin resistant Staphylococcus aureus [MRSA] (Darwish et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Propolis From Tabora and Iringa Regions, Tanzania and Synergism with Gentamicin

Runyoro¹,

Ngassapa²,

Kamugisha³

2017

J App Pharm Sci

View full text Add to dashboard Cite

Antimicrobial resistance (AMR) is among the threats to global public health, with developing countries being mostly affected. The AMR has undermined development of new antimicrobial agents by pharmaceutical industries despite new emerging infections. This necessitates a search for antimicrobial agents from resources available in developing countries. This study, therefore, aimed at assessing antimicrobial activity of two propolis samples from Iringa and Tabora, Tanzania. Ethanolic extracts of the two propolis samples were tested against standard microorganisms including, Gram +ve and Gram -ve bacteria and yeasts by determination of MICs using broth microdilution method. Synergism with Gentamicin was also assessed for one of the samples. Furthermore, HPTLC profiles of the extracts and presence of flavonoids were determined. The two propolis samples exhibited varied activity against the tested microorganisms with MICs ranging from 0.42 to 6.67mg/ml, with Tabora propolis being more active than Iringa propolis. Staphylococcus aureus was the most susceptible microorganism, while Pseudomonas aeruginosa was the most resistant. Propolis also potentiated the activity of Gentamicin. Both samples tested positive for flavonoids. However, there were some differences in their HPTLC profiles. We recommend further studies involving more samples of propolis from various regions of Tanzania to verify further the observed activity and synergism.

show abstract

“…However, studies with propolis prove its antimicrobial, antioxidant, anti-inflammatory, immunomodulatory, hypotensive, healing, anesthetic, anticancer, anti-HIV and anticariogenic properties [13, 15, 21], allowing another way to use it in Dentistry, as in restorative dentistry, propolis can be used to decrease permeability of the dentin and to direct pulp capping in order to create restorative dentin [22]. …”

Section: Discussionmentioning

confidence: 99%

Dentin Cleaning Ability of an Amazon Bioactive: Evaluation by Scanning Electron Microscopy

et al. 2016

View full text Add to dashboard Cite

The role of dentin cleaning is to remove debris that may impair adaptation and marginal sealing, quantitatively reducing microorganisms. The aim of this study was to investigate through scanning electron microscopy (SEM) the morphology of the dentin surface, cut and treated with copaiba oil emulsions (CO) and suspension of ethanol extract of propolis (EP). Twenty four upper pre-molars teeth, divided into eight groups (n=3), were used: G1: no cleaning, G2: air/water spray, G3: 10% CO, G4: 10% CO + A, G5: 30% CO, G6: 30% CO + A, G7: 1% EP, G8: 2% Chlorhexidine. The specimens were dentin discs (1 mm Ø). The SEM photomicrographs were classified and the results were: G1 - Debris dentin on the entire image / countless microorganisms, G2 and G7 - 50-100 debris / countless microorganisms and G3, G4, G5, G6 and G8 - 0-50 debris / countable microorganisms (50-100 colonies).Conclusion:The present results suggest that copaiba oil emulsions (CO) and suspension of ethanol extract of propolis (EP) have feasibility to be used as bioactive dental cleaning agents.

show abstract

Does Propolis Help to Maintain Oral Health?

Cited by 58 publications

References 79 publications

The anti-caries activity and toxicity of an experimental propolis-containing varnish

The anti-caries activity and toxicity of an experimental propolis-containing varnish

Antimicrobial Activity of Propolis From Tabora and Iringa Regions, Tanzania and Synergism with Gentamicin

Dentin Cleaning Ability of an Amazon Bioactive: Evaluation by Scanning Electron Microscopy

Contact Info

Product

Resources

About