2003
DOI: 10.1038/sj.cdd.4401282
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Does prothymosin-α act as molecular switch between apoptosis and autophagy?

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Cited by 25 publications
(23 citation statements)
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“…Mitochondrial damage-induced autophagic cell death may occur especially under conditions where mitochondrialbased apoptosis is not dominant or it is blocked by caspase inhibitors. In support of this idea, in a recent review, Piacentini et al (2003) proposed that, in neurons, the prothymosin-a that inhibits the apoptosome formation may serve as a switch to determine the mode of cell death. According to their model, in case prothymosin-a levels are high enough to block mitochondrial-based apoptosis, cell death will switch to autophagic type, whereas low levels will allow cells to die by apoptosis.…”
Section: Autophagy-apoptosis Connectionmentioning
confidence: 88%
“…Mitochondrial damage-induced autophagic cell death may occur especially under conditions where mitochondrialbased apoptosis is not dominant or it is blocked by caspase inhibitors. In support of this idea, in a recent review, Piacentini et al (2003) proposed that, in neurons, the prothymosin-a that inhibits the apoptosome formation may serve as a switch to determine the mode of cell death. According to their model, in case prothymosin-a levels are high enough to block mitochondrial-based apoptosis, cell death will switch to autophagic type, whereas low levels will allow cells to die by apoptosis.…”
Section: Autophagy-apoptosis Connectionmentioning
confidence: 88%
“…There is evidence in some cases for shared mechanisms and cross-talk between the apoptotic and autophagic death pathways 43 but also for a mechanism for switching between the two pathways 44 that may explain why in many cases a single mechanism predominates in a given cell. 6,9,11,[45][46][47] The present model involved both autophagic and apoptotic features, in line with previous evidence from the same PC12 sub-line showing autophagy and activation of lysosomal cathepsins, but also apoptotic characteristics including clumping of chromatin, activation of caspase-3, moderate protection by acetyl-DEVD.cho (an inhibitor of caspase-3-like proteinases), and strong protection by z-VAD.fmk.…”
Section: Evidence For the Causal Implication Of A Lysosomal Pathwaymentioning
confidence: 99%
“…There are some settings where autophagy and apoptosis seem to be interconnected and the idea of "molecular switches" between the two processes has been introduced (Piacentini et al, 2003). This is similar to the concept of the necrosis-apoptosis "continuum" or "paradox" which suggests that both apoptosis and necrosis represent morphologic expressions of a shared biochemical network in which the route of cell death depends on a variety of factors such as the physiologic milieu, developmental stage, tissue type, and the nature of the cell death signal (Hirsch et al, 1997;Zeiss, 2003).…”
Section: Other Forms Of Programmed Cell Deathmentioning
confidence: 99%