Does protocatechuic acid, a natural antioxidant, reduce renal ischemia reperfusion injury in rats?

Yüksel, Melih; Yildar, Murat; Başbuğ, Murat; Çavdar, Faruk; Çıkman, Öztekin; Akşit, Hasan; Aslan, Figen; Akşit, Dilek

doi:10.5505/tjtes.2016.20165

Cited by 13 publications

(14 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Antioxidant Properties In Othermentioning

confidence: 99%

“…PCA protected renal I/R injury by suppressing oxidative stress and tissue damage [167]. It significantly controlled the serum levels of MDA and TNF-α, and renal MDA level; while on the other hand, it upregulated the serum and renal total antioxidant status (TAS) and SOD levels, and histopathological scores [167]. PCA administration for 28 days suppressed benign prostatic hyperplasia induced by testosterone through reduction of myeloperoxidase (MPO) activity, and NO and MDA levels.…”

Section: Antioxidant Properties In Othermentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant Effects of Protocatechuic Acid and Protocatechuic Aldehyde: Old Wine in a New Bottle

Zhang

Gai

Gui

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Phenolic compounds are naturally present as secondary metabolites in plant-based sources such as fruits, vegetables, and spices. They have received considerable attention for their antioxidant, anti-inflammatory, and anti-carcinogenic properties for protection against many chronic disorders such as neurodegenerative diseases, diabetes, cardiovascular diseases, and cancer. They are categorized into various groups based on their chemical structure and include phenolic acids, flavonoids, curcumins, tannins, and quinolones. Their structural variations contribute to their specific beneficial effects on human health. The antioxidant property of phenolic compounds protects against oxidative stress by up-regulation of endogenous antioxidants, scavenging free radicals, and anti-apoptotic activity. Protocatechuic acid (PCA; 3,4-dihydroxy benzoic acid) and protocatechuic aldehyde (PAL; 3,4-dihydroxybenzaldehyde) are naturally occurring polyphenols found in vegetables, fruits, and herbs. PCA and PAL are the primary metabolites of anthocyanins and proanthocyanidins, which have been shown to possess pharmacological actions including antioxidant activity in vitro and in vivo. This review aims to explore the therapeutic potential of PCA and PAL by comprehensively summarizing their pharmacological properties reported to date, with an emphasis on their mechanisms of action and biological properties.

show abstract

Section: Antioxidant Properties In Othermentioning

confidence: 99%

Section: Antioxidant Properties In Othermentioning

confidence: 99%

Antioxidant Effects of Protocatechuic Acid and Protocatechuic Aldehyde: Old Wine in a New Bottle

Zhang

Gai

Gui

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Thus, protocatechuic acid might exert a potential antihyperglycemic effect that is comparable with that obtained with classical antidiabetic drugs such as gliblenclamide. In other experiment, Yüksel et al [ 30 ] have demonstrated that protocatechuic acid has a protective effect on renal damage by reducing oxidative stress and tissue damage and Safaeian et al [ 31 ], demonstrated that protocatechuic acid prevented hypertension (another coexisting complication of diabetes), reduced plasma H 2 O 2 concentration and increased superoxide dismutase activation. Taking together these data suggests a possible molecular mechanism for protocatechuic acid action.…”

Section: Resultsmentioning

confidence: 99%

Timbe (Acaciella angustissima) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats

et al. 2018

View full text Add to dashboard Cite

In Mexico one in 14 deaths are caused by diabetes mellitus (DM) or by the macro and microvascular disorders derived from it. A continuous hyperglycemic state is characteristic of DM, resulting from a sustained state of insulin resistance and/or a dysfunction of β-pancreatic cells. Acaciella angustissima is a little studied species showing a significant antioxidant activity that can be used as treatment of this disease or preventive against the complications. The objective of this study was to explore the effect of oral administration of A. angustissima methanol extract on physiological parameters of streptozotocin-induced diabetic rats. The results indicated a significant reduction in blood glucose levels, an increase in serum insulin concentration, a decrease in lipid levels and an improvement in the parameters of kidney damage by applying a concentration of 100 mg/Kg B.W. However, glucose uptake activity was not observed in the adipocyte assay. Moreover, the extract of A. angustissima displayed potential for the complementary treatment of diabetes and its complications likely due to the presence of bioactive compounds such as protocatechuic acid. This study demonstrated that methanol extract of Acacciella angustissima has an antidiabetic effect by reducing the levels of glucose, insulin and improved physiological parameters, hypolipidemic effect, oxidative stress and renal damage in diabetic rats.

show abstract

“…It also inhibited the production of inflammatory mediators in keratinocytes stimulated by lipopolysaccharide by reducing the toll like receptor 4-dependent activation of the Akt, mTOR, JNK, and p38 MAPK [ 9 ]. PCA can significantly reduce serum malondialdehyde (MDA), tumor necrosis factor (TNF)-α, and kidney MDA levels in renal ischemia-reperfusion rats, and increase serum and kidney TAS and superoxide dismutase (SOD) levels [ 13 ]. Moreover, it can reduce the ratio of degeneration, oxidative damage, GSH depletion, and microglia activation of neurons in hippocampus and cortex [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Protocatechuic acid as an inhibitor of the JNK/CXCL1/CXCR2 pathway relieves neuropathic pain in CCI rats

Chang

Zhao

2021

Bosn J of Basic Med Sci

View full text Add to dashboard Cite

Emerging evidence has shown that protocatechuic acid (PCA) has antioxidant and anti-inflammatory effects. Evidence suggests that PCA can alleviate the injury of sciatic nerve, while the mechanism of its therapeutic effect on neuralgia remains unknown. Chromium bowel ligation was used in vivo to establish a chronic constriction injury (CCI) rat model to induce sciatic nerve pain. Subsequently, two doses of PCA were used to treat CCI rats. In vitro, 10 ng/mL TNF-α was used to stimulate glial satellite cells derived from the dorsal root ganglia (DRG) L4-L6 of the sciatic nerve to simulate sciatic nerve pain. PCA relieved mechanical allodynia and thermal hyperalgesia in CCI rats. CCK-8 assay revealed that PCA inhibited the proliferation of glial satellite cells induced by TNF-α. Moreover, ELISA demonstrated that PCA could improve the inflammatory response of rats caused by CCI and cells induced by TNF-α. Next, RT-qPCR and Western blot assays showed that PCA blocked the c-Jun N-terminal kinase/the chemokine ligand 1/CXC chemokine receptor 2 (JNK/CXCL1/CXCR2) pathway by inhibiting CXCL1 levels in cells induced by TNF-α and DRG in CCI rats. In conclusion, PCA can alleviate neuropathic pain in CCI rats and improve oxidative stress by inhibiting the JNK/CXCL1/CXCR2 signaling pathway. Thus, these findings provide a new perspective for the treatment of neuropathic pain caused by CCI.

show abstract

Does protocatechuic acid, a natural antioxidant, reduce renal ischemia reperfusion injury in rats?

Cited by 13 publications

References 13 publications

Antioxidant Effects of Protocatechuic Acid and Protocatechuic Aldehyde: Old Wine in a New Bottle

Antioxidant Effects of Protocatechuic Acid and Protocatechuic Aldehyde: Old Wine in a New Bottle

Timbe (Acaciella angustissima) Pods Extracts Reduce the Levels of Glucose, Insulin and Improved Physiological Parameters, Hypolipidemic Effect, Oxidative Stress and Renal Damage in Streptozotocin-Induced Diabetic Rats

Protocatechuic acid as an inhibitor of the JNK/CXCL1/CXCR2 pathway relieves neuropathic pain in CCI rats

Contact Info

Product

Resources

About