Does Quality of Life and Sexual Quality of Life in HIV Patients Differ Between Non-treated HIV Controllers and Treated Patients in the French ANRS VESPA 2 National Survey?

Préau, Marie; Mora, Marion; Puppo, Costanza; Laguette, Vanessa; Sagaon-Teyssier, Luis; Boufassa, Faroudy; Meyer, Laurence; Lambotte, Olivier; Spire, Bruno

doi:10.1007/s10461-018-2237-8

Cited by 8 publications

(6 citation statements)

References 32 publications

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“…Being born in metropolitan France was associated with better scores in the MC and TI dimensions. Even if in the general population, individuals from sub-Saharan Africa reported better mental HRQL (27), in many other context as COVID-19 pandemic, ethnic minorities are recognized as vulnerable to COVID-19 (41) (42), mostly because of their low health literacy and their precarious life conditions (42) (43), including high prevalence of comorbidities (44). Consistent to our study, Drewes and a. underlined that infection, social circumstances, relationships problems, comorbidities (including hypertension), and stigma could have negatively impact the HRQL of PLWHA (45).…”

Section: Discussionmentioning

confidence: 86%

Poor health-related quality of life in people living with HIV co-infected with SARS-CoV-2 in France (the COVIDHIV study)

Amboise,

Yaya,

Yombo-Kokule

et al. 2023

Preprint

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Background: Among people living with HIV/AIDS (PLWHA), comorbid conditions, including COVID-19, could favor impairment of health-related quality of life (HRQL). This study aimed to assess HRQL and its correlates among PLWHA co-infected with SARS-CoV-2 in France. Methods: This cross-sectional study was conducted using data from PLWHA co-infected with SARS-CoV-2 collected at inclusion in the COVIDHIV cohort study. HRQL was measured using the four dimensions of PROQOL-HIV scale: Physical Health Symptom (PHS), Mental and Cognitive (MC), Social Relationship (SR), Treatment Impact (TI). Factors associated with each dimension were identified using linear regression. Findings: Of the 371 participants included in this study, 64.7% were male, their mean age (SD) was 52(±12) years. The mean (SD) scores of the HRQL dimensions were 76.7(±21.1) for PHS, 79.2(±23.6) for SR, 67.3(±27.4) for MC and 83.9(±16.5) for TI. Better PHS score was associated with being professionally active and good self-perceived knowledge about COVID-19. Having acquired HIV by blood transfusion, stage C of CDC HIV-classification, having received discharge instructions in hospital, and number of self-reported symptoms were associated with worse score in PHS dimension. Living in a couple was associated with better SR score. Having received instructions at hospital discharge, being at stage C of CDC HIV-classification, having acquired HIV by drug injection, number of self-reported symptoms, and self-perceived vulnerable to COVID-19 were associated with worse score in SR dimension. Better score in the MC dimension was associated with being professionally active, and being born in metropolitan France, while being female, having detectable HIV viral-load, having received instructions at hospital discharge, self-perceived vulnerable to COVID-19, smoking, and number of self-reported symptoms were associated with worse score in MC dimension. Being born in metropolitan France, having acquired HIV in homosexual or bisexual relationships were associated with better score in TI dimension. Having detectable HIV viral-load, psychiatric disorders, and number of self-reported symptoms were associated with worse score in TI dimension. Conclusion: Among PLWHIV co-infected with SARS-CoV-2, the scores of HRQL were impaired, particularly in the MC dimension. The knowledge of associated factors can help clinicians for better care of this population.

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Section: Discussionmentioning

confidence: 86%

Poor health-related quality of life in people living with HIV co-infected with SARS-CoV-2 in France (the COVIDHIV study)

Amboise,

Yaya,

Yombo-Kokule

et al. 2023

Preprint

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“…In a recent prospective study, HIC reported a slight but significant increase in their quality of life after 24–48 weeks of ART [23] . However, another study reported higher scores in physical and social quality of life for HIC than non-controller treated participants, but lower scores in mental quality of life, interpretated as being associated with the uncertainty of the disease evolution [40] . Further studies are required to investigate the effect of ART on HIC quality of life.…”

Section: Discussionmentioning

confidence: 95%

Antiretroviral therapy for HIV controllers: Reasons for initiation and outcomes in the French ANRS-CO21 CODEX cohort

et al. 2021

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Background Less than 1% of Human Immunodeficiency Virus (HIV)-infected individuals are able to achieve spontaneous viral control without requiring antiretroviral therapy (ART). Whether these HIV controllers (HIC) are at risk of HIV-associated comorbidities and could benefit from ART is debated, but recent studies reported decreased T -cell activation upon ART initiation. We report the frequency of ART initiation, reasons to treat, treatment outcome on immunovirological parameters, and rate of side-effects and treatment discontinuation in the French cohort of HIC. Methods Participants included in the French multicenter Agence Nationale de Recherche sur le SIDA et les Hépatites (ANRS) Cohorte des extremes (CODEX) cohort of HIC between July 6, 2007 and January 3, 2018 were prospectively followed. ART initiation, indication, discontinuation, non-Acquired ImmunoDeficiency Syndrome (AIDS)-defining events, side-effects, and immunovirological parameters were recorded. Undetectable HIC ( u -HIC) were defined as participants with strictly undetectable viral loads based on routinely used assays throughout the follow-up and blipper HIC (b-HIC) as participants with possible detectable viral loads above the detection threshold during follow-up. Findings Among 302 HIC followed for a median of 14.8 years [10.3–20.2], 90 (30%) received ART (7 u-HIC and 83 b-HIC). The main reasons for ART initiation were decreased CD4 T-cell counts ( n = 36, 40%), loss of virological control ( n = 13, 14%), and non-AIDS-defining events ( n = 12, 13%). Sixteen (18%) participants experienced 17 grade 1–2 adverse events. In b-HIC, ART slightly increased the CD4/CD8 ratio (median +0.19, p < 0.0001) and decreased the frequency of circulating CD38 + HLA-DR. + CD4 and CD8 lymphocytes (median -0.75%, p = 0.003, and -2%, p < 0.0001, respectively), but these changes were not observed for treated u-HIC. Thirteen (14%) participants discontinued ART (5 (38%) because of side-effects, and 10 remained HIC after treatment cessation (median follow-up: 305 days [235–728]). Interpretation Only 30% of participants in this large cohort of HIC required ART during a median follow-up of 14.8 years. These results show that HIC status is very stable and vouch for a patient-centered treatment decision based on the individual benefit/risk balance.

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“…Measuring QOL, and its associated factors, is important as it helps understanding the impact of health status on the different aspects of a patient’s daily life. QOL is a complex concept, that not only refers to health but also refers to interactions people have with their living environment [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…The World Health Organization (WHO) defines quality of life (QOL) as "an individual's perception, of his/her place in the existence, in the context of the culture and value system in which she/he lives, in relation to his/her objectives, expectations, standards and concerns" [9]. Measuring QOL, and its associated factors, is important as it helps understanding the impact of health status on the different aspects of a patient's daily life.…”

Section: Introductionmentioning

confidence: 99%

Mid-term health-related quality of life in community-acquired bacterial meningitis survivors; the COMBAT study

et al. 2023

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Background Community Acute Bacterial Meningitis (CABM) is a rare infectious disease leading to important impairments. Our aim was to describe CABM survivors’ quality of life (QOL) 12 months post-CABM and to assess its associations with CABM sequelae. Methods Patients included in the CABM COMBAT cohort were evaluated one year after the CABM episode. Data were collected by questionnaire, via phone calls with the patients. The WHOQOL-BREF was used to measure CABM survivors’ QOL. Hierarchical multivariate linear regressions were performed. Results Study population was composed of 284 patients. At 12 months, 53.9% (153/284) reported at least incident headache/worsening headache intensity at 12 months post-CABM, and/or incident hearing impairment, and/or unfavourable disability outcome (GOS). Unfavourable disability outcome was associated with lower physical health QOL (B = -30.35, p<0.001), lower mental health QOL (B = -15.31, p<0.001), lower environmental QOL (B = -11.08, p<0.001) and lower social relationships QOL (B = -9.62, p<0.001). Incident headache/worsening headache since meningitis onset was associated with lower psychological health (B = -5.62, p = 0.010). Incident hearing impairment was associated with lower physical QOL (B = -5.34, p = 0.030). Hierarchical regressions showed that CABM impairments significantly increase explanatory power of multivariate models (for physical health R2 change = 0.42, p<0.001, for psychological health R2 change = 0.23, p<0.001, for social relationships R2 change = 0.06, p<0.001 and for environment domain R2 change was 0.15, p<0.001). Conclusions 12 month-CABM burden is heavy. Early detection and management of CABM impairments should be performed in clinical practice as early as possible to optimize patients’ psychological and psychosocial functioning. ClinicalTrial. Gov identification number NCT01730690.

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Does Quality of Life and Sexual Quality of Life in HIV Patients Differ Between Non-treated HIV Controllers and Treated Patients in the French ANRS VESPA 2 National Survey?

Cited by 8 publications

References 32 publications

Poor health-related quality of life in people living with HIV co-infected with SARS-CoV-2 in France (the COVIDHIV study)

Poor health-related quality of life in people living with HIV co-infected with SARS-CoV-2 in France (the COVIDHIV study)

Antiretroviral therapy for HIV controllers: Reasons for initiation and outcomes in the French ANRS-CO21 CODEX cohort

Mid-term health-related quality of life in community-acquired bacterial meningitis survivors; the COMBAT study

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