Does real-time elastography aid in differentiating canine splenic nodules?

Alder, Daniela S; Bass, Danielle; Spörri, M; Kircher, Patrick R.; Ohlerth, Stefanie

doi:10.1024/0036-7281/a000498

Cited by 4 publications

(7 citation statements)

References 17 publications

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“…Ultrasonographic elastography is also useful for determining the sampling site for fine‐needle aspiration or biopsy to prevent nondiagnostic or faulty results caused by a poor‐quality or low‐cellularity sample, particularly from hard tissues . In the field of veterinary medicine, ultrasonographic elastography is only applied to a few organs in some animals, including the normal feline liver, kidneys, and spleen; the canine spleen; and the equine tendon using strain elastography and the canine mammary gland tumor; the normal canine liver, spleen, kidneys, and the canine liver disease model using shear‐wave or transient elastography . In canine elastography, the splenic nodule were evaluated using subjective scoring compared to contrast enhanced ultrasound, and other canine elastographic studies using shear‐wave or transient elastography reports evaluate feasibility of canine organs …”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic Elastography of the Liver, Spleen, Kidneys, and Prostate in Clinically Normal Beagle Dogs

Jeon

Lee

et al. 2015

Vet Radiology Ultrasound

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Standard ultrasonography is often insensitive for distinguishing normal vs. diseased states for canine abdominal organs. Ultrasonographic elastography is a new technique that is becoming increasingly available and may help to improve sensitivity. This study evaluated the feasibility, repeatability, and reproducibility of strain elastography of the liver, spleen, kidneys, and prostate in healthy dogs and described the elasticity of each organ using strain values and strain ratios. The reproducibility of strain elastography was excellent, and intraobserver repeatability was moderate to excellent. The strain value of each organ was not significantly different among dogs (liver = 143.38 ± 7.41, spleen = 141.04 ± 9.03, left renal cortex = 141.26 ± 7.50, right renal cortex = 145.80 ± 7.79, and prostate = 135.46 ± 5.80), except for the renal medulla (left = 51.19 ± 4.54 and right = 51.93 ± 5.09) (P < 0.05). The strain ratios for the liver, spleen, renal cortex, and prostate were similar with no significant difference (liver = 10.20 ± 1.47, spleen = 8.40 ± 1.53, left renal cortex = 9.62 ± 1.56, right renal cortex = 8.29 ± 1.63, and prostate = 8.20 ± 1.21), except for the renal medulla (left = 3.48 ± 0.68 and right = 2.95 ± 0.63) (P < 0.05). Our results indicated that strain elastography was feasible for estimating tissue stiffness in the canine liver, spleen, kidneys, and prostate. This study provides basic information for strain values and strain ratios for the liver, spleen, kidneys, and prostate in clinically normal dogs. C 2015 American College of Veterinary Radiology.

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Section: Introductionmentioning

confidence: 99%

Ultrasonographic Elastography of the Liver, Spleen, Kidneys, and Prostate in Clinically Normal Beagle Dogs

Jeon

Lee

et al. 2015

Vet Radiology Ultrasound

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“…There is only one animal study which examined the use of strain elastography in FSLs in dogs [22]. Adler et al used strain elastography on 22 dogs with 14 FSLs (8 benign, 6 malignant, and 8 normal spleens), and there were no significant differences between the benign and malignant FSLs, nor between the FSLs and NSPs [22].…”

Section: Discussionmentioning

confidence: 99%

Acoustic Radiation Force Impulse (ARFI) Elastography of Focal Splenic Lesions: Feasibility and Diagnostic Potential

Alhyari,

Görg,

Tahat

et al. 2023

Cancers

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Purpose: Nontraumatic focal splenic lesions (FSL) are rare, and the need for tissue diagnosis must be weighed against the very high risk of bleeding after a splenic biopsy. The aim of this study was to explore the feasibility and diagnostic potential of acoustic radiation force impulse (ARFI) elastography as a noninvasive method for different benign and malignant FSLs. No human studies on the elastographic characteristics of FSL exist. Methods: This was a retrospective analysis of 34 patients with FSLs, who underwent abdominal B-mode ultrasound (B-US), contrast-enhanced ultrasound (CEUS), and standardized ARFI examinations between October 2021 and December 2022 at our university hospital. The inclusion criteria were: (i) FSL size ≥ 1 cm; (ii) 10 valid ARFI measurements of the FSL, as well as of the normal splenic parenchyma (NSP) as an in vivo reference; and (iii) diagnostic confirmation of FSL etiology based on histological examination (8/34; 23.5%) or clinical evaluation, which included a clinical and sonographic follow-up (FU), CEUS morphology, and/or morphology on cross-sectional imaging (26/34; 76.5%). CEUS was performed on all patients and the FSLs were classified according to the current guidelines; cross-sectional imaging was available for 29/34 (85.3%). The mean FU duration was 25.8 ± 30.5 months. The mean ARFI velocity (MAV) of the FSL (MAVL), the NSP (MAVP), and the ratio of the MAVL to the MAVP (MAVL/P) were calculated and compared. Results: Of the 34 FSLs, 13 (38.2%) were malignant (mFSL) and 21 (61.8%) were benign (bFSL). The MAVL of all 34 FSLs (2.74 ± 0.71 m/s) was lower than the MAVP (3.20 ± 0.59 m/s), p = 0.009, with a mean MAVL/P ratio of 0.90 ± 0.34. No significant differences in the MAVL were observed between the mFSL (2.66 ± 0.67 m/s) and bFSL (2.79 ± 0.75 m/s). There were also no significant differences between the MAVP in patients with mFSL (3.24 ± 0.68 m/s) as compared to that in the patients with bFSL (3.18 ± 0.55 m/s). Likewise, the MAV L/P ratio did not differ between the mFSL (0.90 ± 0.41 m/s) and bFSL (0.90 ± 0.30 m/s) groups. Conclusion: ARFI elastography is feasible in evaluating the stiffness of FSLs. The lesions’ stiffness was lower than that of the NSP, regardless of the FSL etiology. However, differentiation between benign and malignant FSL with the help of this elastographic method does not appear possible. Larger prospective studies are needed to validate these findings.

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“…15,17 Although the effect of sedation on renal or pancreatic SWV in 2-D SWE has not yet been assessed, the effect of a sedative drug on the SWV of the canine spleen has been evaluated. 15,18 A combination of zolazepam hydrochloride-tiletamine hydrochloride and medetomidine hydrochloride increased splenic SWV in the 2-D SWE of dogs. 15 The stiffness of the splenic nodules did not differ significantly between nonsedated and sedated dogs using a butorphanol and midazolam combination, a fentanyl and midazolam combination, a butorphanol and acepromazine combination, or methadone in strain elastography.…”

Section: Clinical Relevancementioning

confidence: 98%

Sedative effect with the combination of butorphanol and midazolam on two-dimensional shear wave elastography of pancreas and kidney in healthy dogs

Cho

Yang²,

Suh

et al. 2023

ajvr

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OBJECTIVE To evaluate the sedative effect of a combination of butorphanol and midazolam on 2-D shear wave elastography (SWE) of the kidneys and pancreas in dogs. ANIMALS 8 clinically healthy dogs. PROCEDURES We conducted a 2-D SWE examination of the bilateral kidneys and the pancreas before and after IV of 0.2 mg/kg butorphanol and 0.1 mg/kg midazolam in each dog. We performed 2-D SWE on the left kidney via a subcostal approach with the dog in right lateral recumbency, on the right kidney via the intercostal approach with the dog in left lateral recumbency, and on the right lobe of the pancreas via the subcostal approach. Subsequently, the pancreas and kidney shear wave velocities (SWV) pre- and postsedation were compared. RESULTS On qualitative evaluation using color mapping, the pancreas and kidneys showed a homogeneous blue-to-green color in pre- and post-sedation 2-D SWE. There was no significant difference in SWV pre- and post-sedation in the pancreas and kidneys. CLINICAL RELEVANCE Intravenous administration of a combination of 0.2 mg/kg butorphanol and 0.1 mg/kg midazolam did not change the 2-D SWE of the pancreas and kidneys significantly. The combination of butorphanol and midazolam can be used in healthy dogs for 2-D SWE evaluation of the pancreas and kidneys, especially when the patient is uncooperative during the examination.

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Does real-time elastography aid in differentiating canine splenic nodules?

Cited by 4 publications

References 17 publications

Ultrasonographic Elastography of the Liver, Spleen, Kidneys, and Prostate in Clinically Normal Beagle Dogs

Ultrasonographic Elastography of the Liver, Spleen, Kidneys, and Prostate in Clinically Normal Beagle Dogs

Acoustic Radiation Force Impulse (ARFI) Elastography of Focal Splenic Lesions: Feasibility and Diagnostic Potential

Sedative effect with the combination of butorphanol and midazolam on two-dimensional shear wave elastography of pancreas and kidney in healthy dogs

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