Does reflux have an effect on nasal mucociliary transport?

Durmus, Ruhi; Naiboğlu, Barış; Tek, Arman; Sezıklı, Mesut; Çetinkaya, Züleyha Akkan; Toros, Sema Zer; Eriman, Talip Murat; Egeli, Erol

doi:10.3109/00016481003621546

Cited by 18 publications

(15 citation statements)

References 19 publications

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“…The mechanism for this is believed to be due to direct effects of refluxate on nasal/sinus mucosa, although no consistent effect of LPR on nasal mucociliary clearance has been demonstrated. 47 One study found that patients with LPR had higher scores on the Sinonasal Outcome Test (SNOT-20), even in the absence of a diagnosis of CRS, 48 and another study showed that patients with LPR had higher scores for postnasal drainage. 49 Some of this association could be due to overlapping symptoms between LPR and CRS.…”

Section: Humoral or Innate Immune Deficiencymentioning

confidence: 98%

Chronic rhinosinusitis: Epidemiology and medical management

Hamilos

2011

Journal of Allergy and Clinical Immunology

361

296

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Section: Humoral or Innate Immune Deficiencymentioning

confidence: 98%

Chronic rhinosinusitis: Epidemiology and medical management

Hamilos

2011

Journal of Allergy and Clinical Immunology

361

296

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“…25 Durmus et al, measured MCT using saccharin test in 50 cases diagnosed with GERD and LPRD and 30 healthy controls. 26 There was no statistically significant difference between the saccharin transit test results of the study and control group. Wong et al reported that only 0.2% of 809 reflux episodes had reached the nasopharynx using 24h ambulatory pH monitoring in 40 CRS subjects.…”

Section: Discussionmentioning

confidence: 65%

Does laryngopharyngeal reflux disease impair nasal mucociliary transport? A case control prospective study

Vasu

Nayana

Somayaji

2020

Int J Otorhinolaryngol Head Neck Surg

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Background: Laryngopharyngeal reflux disease (LPRD) is the retrograde reflux of gastro duodenal contents above the level of upper oesophageal sphincter into larynx and pharynx. LPRD can lead to upper respiratory pathology by direct contact of nasal and nasopharyngeal mucosa with the regurgitated gastric acid. Refluxate can damage the cilia, thereby prolonging the mucociliary clearance time (MCT) and consequently affecting the innate defence mechanism of upper airway. Our objective was to analyse the relationship between MCT and LPRD in patients without any nasal pathology.Methods: This study was a prospective case control study, with 45 patients each in the study and reference group. Study group included patients with symptoms of LPRD who fulfilled the reflux symptom index (RSI) score of more than 13 points. The reference group included subjects without LPRD, with RSI less than 13. In both groups, conditions causing impaired MCT like allergic rhinitis, sinusitis, rhinitis and history of smoking were excluded. Chronic sinusitis cases were excluded in both groups using sino-nasal outcome test -22 scoring system. Nasal MCT was measured in all these participants using the Saccharin test. Duration more than 20 minutes was taken as prolonged mucociliary clearance time. Results: MCT was prolonged in 62% of subjects (28 out of 45) in the study group whereas, in the reference population MCT was normal.Conclusions: LPRD is a contributing factor for impaired nasal mucociliary transport.

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“…However, a study by Durmus et al showed no improvement in symptoms of refractory CRS in patients with PPI. [21] Studies have shown that reflux leads to poor post FESS symptomatic outcomes. [6] In our study also we found that in patients of control group where PPI were not added to treatment, patients had much lesser improvement with FESS alone as treatment as compared to study group.…”

Section: Discussionmentioning

confidence: 99%

Correlation between chronic rhinosinusitis and laryngopharyngeal reflux

Nanda¹,

Kaur²,

Gupta³

2017

Natl J Physiol Pharm Pharmacol

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Background: Chronic rhinosinusitis (CRS) is a major Ear, Nose and Throat disease and there are higher numbers of refractory cases poorly responding to medical and surgical treatment. Laryngopharyngeal reflux (LPR) is said to be the important cause for same. Aims and Objectives: This study aims to study the incidence of LPR in patients of refractory CRS. This study also aims to study the impact of proton pump inhibitors (PPI) (effective treatment of LPR) given as adjuvant therapy along with functional endoscopic sinus surgery (FESS) in patients with refractory CRS. Materials and Methods: A total of 40 patients of refractory CRS taken up for the study were evaluated for signs and symptoms of LPR. They were then divided into two groups of 20 each -study group and control group. All the patients in both groups were evaluated for signs and symptoms of CRS. All these patients underwent FESS. Post-surgery patients in the study group were given intranasal steroids (INS) along with PPI (tablet pantoprazole) whereas in control group were put on INS without PPI. The patients were followed monthly for 3 months for improvement in signs and symptoms of CRS and patient's relief and comfortability levels. Results: 45% of patients of refractory CRS had LPR with the posterior larynx being mainly involved. The major signs and symptoms of CRS were nasal obstruction, nasal discharge, and nasal polyps. There was more improvement in nasal obstruction, nasal discharge, and post-nasal discharge in patients of study group with PPI as compared to control group without PPI. There was better relief of symptoms in patients given PPI as compared to control group and this improvement was more marked at 3 rd post-operative visit after 3 months. Conclusion: There is a strong association between refractory CRS and LPR. PPI are an effective drug for refractory CRS when given as adjuvant therapy along with FESS.

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Does reflux have an effect on nasal mucociliary transport?

Cited by 18 publications

References 19 publications

Chronic rhinosinusitis: Epidemiology and medical management

Chronic rhinosinusitis: Epidemiology and medical management

Does laryngopharyngeal reflux disease impair nasal mucociliary transport? A case control prospective study

Correlation between chronic rhinosinusitis and laryngopharyngeal reflux

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