BackgroundThe renewal of removable dentures is often suggested to denture wearers subject to discomfort. However, the impact of this rehabilitation on patients’ oral health related quality of life and their removable dentures related satisfaction is still unknown. This study was aimed at assessing these patient-centered outcomes and the potential impact of different factors.MethodsA cohort of 116 patients in need of removable dental prostheses rehabilitation was recruited at a dental hospital over a period of 1 year. The subjects were separated into two groups according to their prosthesis experience (group in need of removable dentures renewal/group needing an removable dentures for the first time). Subjects were asked to answer the “Geriatric Oral Health Assessment Index” (GOHAI) and the “McGill Denture Satisfaction Instrument” before and after a prosthesis integration period (9–12 weeks).ResultsGOHAI scores were slightly higher for patients with removable dentures renewal (from 40.6 ± 10.3 to 47.1 ± 10.0, p < 0.001), independently of the type of prosthetic rehabilitation. However, the scores of the GOHAI functional field did not change. Subjects with no removable dentures experience presented an increase in their functional GOHAI score (p < 0.001). Regarding patient removable dentures related satisfaction, only the “Esthetic” (p < 0.001), “Chewing efficiency” (p < 0.001) and “Oral condition” (p < 0.01) items increased after prosthesis renewal.ConclusionsThis study showed that renewing removable dentures only moderately improved the oral health related quality of life and removable dentures related satisfaction of patients, regardless of age, gender or type of rehabilitation. Other tasks are necessary such as the analysis of physiological parameters and qualitative research on patient’s expectations.