Does removal of CU-IUD in patients with biofilm forming candida really maintain regression of clinical symptoms?

Çakıroğlu, Yiğit; Döğer, Emek; Özcan, Sema Keçeli; Çalışkan, Eray

doi:10.3109/01443615.2014.986442

Cited by 12 publications

(13 citation statements)

References 18 publications

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“…Biofilm formation has been proposed as one of the most important virulence factors of C. albicans causing vaginal candidiasis, contributing to the establishment and recurrence of the infection (Muzny and Schwebke, 2015). Although biofilm formation of C. albicans has been extensively studied with clinical isolates from vaginal candidiasis patients, most studies used in vitro systems for biofilm cultivation that might only represent biofilms formed on IUDs (Cakiroglu et al, 2015;Gao et al, 2016;Sherry et al, 2017). Only a few studies have been carried out on biofilms grown on the vaginal epithelium (Harriott et al, 2010;Peters et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, the role of epithelium-associated C. albicans biofilm in the development of vaginal candidiasis has been proposed (Harriott et al, 2010;Rodriguez-Cerdeira et al, 2019), though a recent study by Swidsinski et al (2019) did not detect evident biofilms from the vaginal biopsies from patients with confirmed vaginal candidiasis. Two different types of biofilms might be involved in vaginal candidiasis: abiotic biofilms that require a plastic or metal substratum, such as intrauterine devices (IUDs;Auler et al, 2010;Cakiroglu et al, 2015), and biotic biofilms that use the vaginal epithelium as the supporting base (Harriott et al, 2010;Muzny and Schwebke, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Epithelium-associated biotic biofilms were considered to be more important in the pathogenesis of recurrent vaginal candidiasis, as many patients suffer from recurrent infections without any IUDs implanted or after the removal of IUDs (Cakiroglu et al, 2015). Using a mouse vaginal candidiasis model, Harriott et al (2010) successfully established C. albicans biofilms on the vaginal epithelium and raised the hypothesis that formation of epithelium-associated biofilms may be an initiating event for the infection (Harriott et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Biofilm Formation of Candida albicans Facilitates Fungal Infiltration and Persister Cell Formation in Vaginal Candidiasis

Zhang

et al. 2020

Front. Microbiol.

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Background: Vaginal candidiasis is an important medical condition awaiting more effective treatment. How Candida albicans causes this disease and survives antifungal treatment is not yet fully understood. This study aimed to establish a comprehensive understanding of biofilm-related defensive strategies that C. albicans uses to establish vaginal candidiasis and to survive antifungal treatment. Methods: A mouse model of vaginal candidiasis was adopted to examine the formation of biotic biofilms on the vaginal epithelium and fungal infiltration by laboratory and clinical strains of C. albicans. Histopathological changes and local inflammation in the vaginal epithelium caused by C. albicans of different biofilm phenotypes were compared. Antifungal susceptibility testing was carried out for C. albicans grown as planktonic cells, microplate-based abiotic biofilms, and epithelium-based biotic biofilms. Formation of persister cells by C. albicans in different growth modes was also quantified and compared. Results: C. albicans wild-type reference strains and clinical isolates, but not the biofilm-defective mutants, formed a significant number of biotic biofilms on the vaginal epithelium of mice and infiltrated the epithelium. Biofilm formation and epithelial invasion induced local inflammatory responses and histopathological changes in the vaginal epithelium including neutrophil infiltration and subcorneal microabscesses. Biofilm growth on the vaginal epithelium also led to high resistance to antifungal treatments and promoted the formation of antifungal-tolerant persister cells. Conclusion: This study comprehensively assessed biofilm-related microbial strategies that C. albicans uses in vaginal candidiasis and provided experimental evidence to support the important role of biofilm formation in the histopathogenesis of vaginal candidiasis and the recalcitrance of the infection to antifungal treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biofilm Formation of Candida albicans Facilitates Fungal Infiltration and Persister Cell Formation in Vaginal Candidiasis

Zhang

et al. 2020

Front. Microbiol.

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“…148,149 For both Cu-IUD and LNG-IUS users, there is mixed evidence of limited quality with some studies suggesting higher rates of Candida infection whilst others show an increase in Candida present but no difference in symptomatic cases. 143,150–153…”

Section: Treatmentsmentioning

confidence: 99%

British Association for Sexual Health and HIV national guideline for the management of vulvovaginal candidiasis (2019)

et al. 2020

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“…Keputihan telah menjadi salah satu infeksi yang paling umum pada saluran genital bawah dan jutaan perempuan berusia lebih dari 25 tahun (Cakiroglu et al, 2014). Keputihan mempengaruhi hingga 75% wanita usia reproduksi setidaknya sekali, hampir setengah akan mengalami kekambuhan, dan 5-8% memiliki beberapa episode setiap tahun.…”

Section: Pendahuluanunclassified

Hubungan Akseptor Kb Iud Dengan Kejadian Keputihan Di Puskesmas Jetis Kota Yogyakarta

Mayangsari¹,

Saidah²,

Lidia³

2019

jkmm

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The implementation of the Family Planning (KB) program in Indonesia raisesvarious problems in the health sector which are generally experienced by many women.One of the problems faced by women in line with the dissemination of this program inIndonesia is the emergence of vaginal problems in the use of Intra-Uterine Device (IUD)contraception. Leucorrhoea is abnormal vaginal secretion in women, the longer the useof an IUD, the more at risk of developing vaginal discharge. This study aims to study andanalyze the relationship between IUD KB acceptors and vaginal discharge. The researchdesign used was an observational method with a cross sectional study design. Sample sizewas 92 patients. The sample used was patients aged 18-60 years who sufferedleucorrhoea at the Jetis Primary Health Center, Yogyakarta City. Sampling usingpurposive sampling technique. The relationship between intra-uterine devicecontraceptive acceptors and vaginal discharge was analyzed using Chi-Square using theSPSS version 21.0 for Windows program. There was a statistically significant associationof patients using intra-uterine device contraception and experiencing vaginal dischargetotaling 43 people (46.7%) and 12 people who did not experience vaginal discharge(13.1%). While patients who did not use intra-uterine device contraception and hadvaginal discharge were 21 people (22.8%) and those who did not suffer from vaginaldischarge were 16 people (17.4%). The Chi-square hypothesis test results obtainedsignificance 0.029 where p <0.05. There is a relationship between intra-uterine devicecontraceptive acceptors and the incidence of vaginal discharge in the Jetis PrimaryHealth Center in Yogyakarta which is statistically significant.

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Does removal of CU-IUD in patients with biofilm forming candida really maintain regression of clinical symptoms?

Abstract: Biofilm forming microorganisms should be considered in the management of vaginal infections or symptoms for safer use of intrauterine devices.

Cited by 12 publications

References 18 publications

Biofilm Formation of Candida albicans Facilitates Fungal Infiltration and Persister Cell Formation in Vaginal Candidiasis

Biofilm Formation of Candida albicans Facilitates Fungal Infiltration and Persister Cell Formation in Vaginal Candidiasis

British Association for Sexual Health and HIV national guideline for the management of vulvovaginal candidiasis (2019)

Hubungan Akseptor Kb Iud Dengan Kejadian Keputihan Di Puskesmas Jetis Kota Yogyakarta

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