Does replacement of vitamin D reduce the symptom scores and improve quality of life in patients with chronic urticaria?

Topal, İlteriş Oğuz; Kocatürk, Emek; Güngör, Şükrü; Durmuşcan, Mustafa; Sucu, Veysel; Yildirmak, Sembol

doi:10.3109/09546634.2015.1079297

Cited by 30 publications

(34 citation statements)

References 18 publications

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“…Previously, some authors reported symptom alleviation of urticaria after administration of vitamin D supplementation [15]. Our data also support this theory in different ways regarding improving health outcome, quality of life, and severity of the disease in a patient with CSU.…”

Section: Discussionsupporting

confidence: 87%

Amelioration of patients with chronic spontaneous urticaria in treatment with vitamin D supplement

et al. 2017

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BackgroundSpontaneous urticaria is a common allergic skin condition affecting 0.5–1% of individuals and may burden on health care expenditure or may be associated with remarkable morbidity.AimIn this study, we measured the effect of vitamin D supplementation in patients with a diagnosis of CSU. Furthermore, quality of life and cytokine changes were evaluated.MethodsThe clinical trial was conducted on 20 patients with idiopathic chronic urticaria. Vitamin D was administered orally for 8 weeks and disease activity was measured pre- and post-treatment using USS and DLQI. On the other hand expressions of IL-17, IL-10, Foxp3, and TGF-β by Real-time RT-PCR were assessed.ResultsUSS questionnaire showed that severity of idiopathic urticaria after the intervention, which compared with the first day reached a significant 55% reduction. The DLQI quality of life questionnaire 2 months after treatment showed 55% improvement. Along with the significant improvement of clinical symptoms, use of vitamin D increase FOXP3 gene expression and downregulation of IL-10, TGF-B, and FOXP3, IL-17, but these changes were not statistically significant.LimitationThese might happen due to lack of enrolled population in the investigation.ConclusionVitamin D can be used along with standard medical care and it’s a safe and cost-effective method for the treatment of chronic urticaria with deficiency of vitamin D.

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Section: Discussionsupporting

confidence: 87%

Amelioration of patients with chronic spontaneous urticaria in treatment with vitamin D supplement

et al. 2017

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“…However, recent studies reported that vitamin D levels in adults are inversely correlated with chronic urticaria,15 chronic urticaria severity,16 and treatment responsiveness of patients with chronic urticaria 18. The discrepancy between ours and previous studies may be due to: (1) differences between adults and children with regard to hormone secretion as well as the uptake and utility of calcium and vitamin D;30 (2) difference in control populations, healthy controls, and controls with allergic rhinitis;15 (3) differences in vitamin D levels (since the younger generation is at risk for vitamin insufficiency in Korea,31 vitamin D insufficiency may not have a significant difference on chronic urticaria as the other population of previous studies); (4) the time of blood sampling because of seasonal variation in vitamin D level differences (since the subjects were tested at a certain time of the year, the test results may not reflect the overall vitamin D levels throughout the whole year);1617 and (5) the number of patients with chronic urticaria is small in our study (it may not be the representative value).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that chronic idiopathic urticaria is associated with infection,11 pseudo-allergy to a food,12 autoimmunity,1314 and low serum level of vitamin D 15161718. However, there is little information on the relationship of chronic urticaria with type of residence, overcrowding, socio-economic status, air pollutants, exposure to secondary smoke, and other life style factors that have established importance in other allergic diseases 121920…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Urticaria With a Focus on Chronic Urticaria in Children

Lee

Jee

et al. 2017

Allergy Asthma Immunol Res

148

150

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PurposeLimited data is available on the prevalence and risk factors of acute and chronic urticaria in children. Our purpose was to determine the prevalence and identify the risk factors of acute and chronic urticaria in Korean children.MethodsThis population-based study examined 4,076 children (age 4 to 13 years) who were enrolled in the 2015 prospective Seongnam Atopy Project (SAP 2015) in Korea. The parents completed an urticaria questionnaire that included questions regarding the duration, severity, and triggering factors of urticaria. Blood sampling (n=464) was performed to measure vitamin D, total eosinophil count (TEC), and total IgE levels, and skin prick tests (n=503) were done.ResultsThe prevalences of the life-time, acute, and chronic urticaria were 22.5%, 13.9%, and 1.8% (chronic continuous urticaria, 0.7%; and chronic recurrent urticaria, 1.1%), respectively. Acute urticaria was significantly associated with allergic diseases and parental history of allergy (P<0.001), but chronic urticaria was not associated with these clinical factors. There was no significant difference in the 25-hydroxyvitamin D level between subjects with chronic urticaria and controls (P=0.124). Chronic continuous urticaria was associated with living in a new residence (aOR=2.38, 95% CI=1.02-5.54, P=0.044) and belonging to a family with a high income (aOR=4.24, 95% CI=1.24-14.56, P=0.022).ConclusionsA total of 1.8% of children were found to have chronic urticaria. Living in a new residence and belonging to a family with a high income increased the risk of chronic continuous urticaria.

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“…Lastly, a recent prospective case-control study comparing vitamin D levels in 58 chronic spontaneous urticaria (CSU) patients and 45 controls found that vitamin D levels were significantly lower in CSU patients [65]. Patients with 25[OH]D levels less than 30 ng/mL were treated with 300,000 IU/month of vitamin D3 supplementation.…”

Section: Chronic Urticariamentioning

confidence: 99%

Vitamin D in atopic dermatitis, chronic urticaria and allergic contact dermatitis

Quirk

Rainwater

Shure

et al. 2016

Expert Review of Clinical Immunology

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Summary Vitamin D influences allergen-induced pathways in the innate and adaptive immune system, and its potential immunomodulatory role in allergic skin disorders has been explored. This comprehensive review article provides an overview of the role of vitamin D in three common dermatologic conditions: atopic dermatitis (AD), chronic urticaria, and allergic contact dermatitis (ACD). Whereas the literature regarding vitamin D and AD has resulted in mixed findings, several studies have described an inverse relationship between vitamin D levels and AD severity, and improvement in AD with vitamin D supplementation. Similarly, several studies report an inverse relationship between vitamin D levels and severity of chronic urticaria. Although current research in humans remains limited, an increased likelihood of ACD has been demonstrated in vitamin D-deficient mice. Additional well-designed clinical trials will be necessary to determine whether vitamin D supplementation should be recommended for prevention or adjuvant treatment of these common dermatologic conditions.

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Does replacement of vitamin D reduce the symptom scores and improve quality of life in patients with chronic urticaria?

Abstract: This study support the contributing and beneficial effects of vitamin D in the treatment of CU. Replacement of vitamin D may provide improvement in both the severity of symptoms and the quality of life scores in these patients.

Cited by 30 publications

References 18 publications

Amelioration of patients with chronic spontaneous urticaria in treatment with vitamin D supplement

Amelioration of patients with chronic spontaneous urticaria in treatment with vitamin D supplement

Prevalence and Risk Factors of Urticaria With a Focus on Chronic Urticaria in Children

Vitamin D in atopic dermatitis, chronic urticaria and allergic contact dermatitis

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