Does retrieval frequency account for the pattern of autobiographical memory loss in early Alzheimer's disease patients?

Simone, Maria Stefania De; Fadda, Lucia; Perri, Roberta; Aloisi, Marta; Caltagirone, Carlo; Carlesimo, Giovanni Augusto

doi:10.1016/j.neuropsychologia.2015.11.024

Cited by 24 publications

(26 citation statements)

References 48 publications

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“…Specifically, retrieval of remote material seems to be better preserved than recent memories. Overall, it has been highlighted that in AD ABM impairments are characterized by a temporal gradient for both episodic and semantic components (Leyhe et al, 2009;Thomann et al, 2012;De Simone et al, 2016;Kirk and Berntsen, 2018).…”

Section: The Remote Self In Admentioning

confidence: 99%

The Petrified Self 10 Years After: Current Evidence for Mnemonic anosognosia

2020

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Lack of awareness about disease, its symptoms and consequences, also termed anosognosia, is a common feature of Alzheimer's disease (AD). It has been hypothesized that memory disorder may be a key contributing factor to anosognosia, with people with AD not being able to update their personal information about performance and relying on older consolidated material about ability. This potentially outdated sense of self has been named, as a metaphor, the petrified self. In the current review, evidence from the past 10 years in relation to this concept is critically appraised. In particular, focus is given to empirical evidence produced on anterograde memory deficits about performance, the profile of autobiographical retrograde memory loss and the role of frontal lobes in anosognosia in AD. Finally, wider consequences of this metaphor for the understanding of selfhood in dementia are discussed.

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Section: The Remote Self In Admentioning

confidence: 99%

The Petrified Self 10 Years After: Current Evidence for Mnemonic anosognosia

2020

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“…In our previous study [33], we found that both retrieval frequency and age of memory play a fundamental role in modulating the pattern of autobiographical RA in early AD patients. However, different results have been obtained in assessing the pattern of semantic RA in the same type of patients [26,27], because only frequency of retrieval, and not age of memory, affected the severity and extension of RA.…”

Section: Discussionmentioning

confidence: 85%

“…Whether earlier studies have primarily focused on how RA declines as a function of the time periods considered, i.e., from the most remote to the most recent ones, only few studies [26,27,33] have tested the impact of retrieval frequency on the extent and severity of remote episodic and semantic amnesia, as postulated by the MTT, in neurodegenerative pathology. In the first work [26], the authors assessed the recall of famous public events in early AD patients using a novel approach that allows evaluating separately how memory accuracy changes as a function of the age of the event (remote versus recent events) and retrieval frequency (more frequently versus less frequently retrieved events).…”

Section: Introductionmentioning

confidence: 99%

“…Both studies concluded that frequency of retrieval, rather than age of memory, affects the severity of retrograde amnesia in clinical and preclinical AD. In a recent study by our group [33], we combined the Autobiographical Memory Interview [12] with the novel procedure used by Muller and colleagues [26] to evaluate memory for autobiographical incidents as a function of their age of acquisition and retrieval frequency in a sample of early AD patients. Compared with the two studies cited above, our findings provide new evidence that a combined action of both the time course and the retrieval frequency would offer a more exhaustive explanation of the pattern of autobiographical memory loss than only one of these two factors.…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, as we hypothesized that the mixed results reported in the above cited studies [26,27,33] are probably due to the different components of retrograde memory under investigation, the main aim of this study was to test whether retrieval frequency and memory age play different roles according to the semantic or episodic components of the memory to recall. For this purpose, a sample of aMCI patients and matched healthy controls (HC) were submitted to an experimental investigation of both semantic and autobiographical memories related to past public events in order: i) to evaluate the specific pattern of episodic and semantic RA in patients with mild hippocampal damage across different time periods and different degrees of retrieval frequency; ii) to examine whether the contribution of these two factors (retrieval frequency and age of memory acquisition) changes according to the type of memory.…”

Section: Introductionmentioning

confidence: 99%

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Retrograde Amnesia for Episodic and Semantic Memories in Amnestic Mild Cognitive Impairment

Simone

Fadda

Perri

et al. 2017

JAD

Self Cite

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Abstract. Retrograde amnesia (RA), which includes loss of memory for past personal events (autobiographical RA) and for acquired knowledge (semantic RA), has been largely documented in patients with amnestic mild cognitive impairment (aMCI). However, previous studies have produced controversial results particularly concerning the temporal extent of memory impairment. Here we investigated whether, with the onset of hippocampal pathology, age of memory acquisition and retrieval frequency play different roles in modulating the progressive loss of semantic and episodic contents of retrograde memory respectively. For this purpose, aMCI patients and healthy controls were tested for the ability to recall semantic and autobiographical information related to famous public events as a function of both age of acquisition and retrieval frequency. In aMCI patients, we found that the impairment in recollecting past personal incidents was modulated by the combined action of memory age and retrieval frequency, because older and more frequently retrieved episodes are less susceptible to loss than more recent and less frequently retrieved ones. On the other side, we found that the loss of semantic information depended only on memory age, because the remoteness of the trace allows for better preservation of the memory. Our results provide evidence that the loss of the two components of retrograde memory is regulated by different mechanisms. This supports the view that diverse neural mechanisms are involved in episodic and semantic memory trace storage and retrieval, as postulated by the Multiple Trace Theory.

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The cognitive characteristics of music‐evoked autobiographical memories: Evidence from a systematic review of clinical investigations

Kaiser

Berntsen

2022

WIRES Cognitive Science

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In healthy adults, autobiographical memories (AMs) evoked by music appear to have unique cognitive characteristics that set them apart from AMs evoked by other cues. If this is the case, we might expect music cues to alleviate AM deficits in clinical disorders. This systematic review examines music-evoked autobiographical memories (MEAMs) in clinical populations, focusing on cognitive characteristics, and whether MEAMs differ from AMs evoked by other stimuli.We identified 15 studies featuring participants with Alzheimer's disease (AD), behavioral variant -Frontotemporal dementia (bv-FTD), acquired brain damage, and depression. We found that music evokes AMs in these disorders, and that familiar music was more likely to evoke AMs. Compared with healthy controls, AD participants had a relative advantage for MEAMs over picture-evoked AMs. People with damage to the medial prefrontal cortex showed preserved access to MEAMs in terms of frequency, but a relative disadvantage regarding the episodic richness for MEAMs, but not for memories cued by pictures, compared to controls. Participants with bv-FTD had fewer AMs evoked after both music and pictures than healthy controls. Across conditions, MEAMs were generally specific and retrieved fast, suggesting little retrieval effort. MEAMs were also positive, except in depression, where as many negative as positive AMs were produced. These findings suggest several underlying cognitive and affective mechanisms of MEAMs, including anxiety reduction, increased fluency, musicevoked emotions, reminiscence, and involuntary retrieval, and that these might be moderated by musical abilities and memory for music. In conclusion, MEAMs appear to be relatively well preserved, especially in AD.

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Does retrieval frequency account for the pattern of autobiographical memory loss in early Alzheimer's disease patients?

Cited by 24 publications

References 48 publications

The Petrified Self 10 Years After: Current Evidence for Mnemonic anosognosia

The Petrified Self 10 Years After: Current Evidence for Mnemonic anosognosia

Retrograde Amnesia for Episodic and Semantic Memories in Amnestic Mild Cognitive Impairment

The cognitive characteristics of music‐evoked autobiographical memories: Evidence from a systematic review of clinical investigations

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