Does Sertraline Affect Hypothalamic Food Intake Peptides in the Rat Experimental Model of Chronic Mild Stress-Induced Depression?

Solak, Hatice; Görmüş, Zülfikare İşık Solak; Koca, Raviye Özen; Güneş, Canan Eroğlu; Kutlu, Selim

doi:10.1007/s11064-022-03529-9

Cited by 4 publications

(1 citation statement)

References 62 publications

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“…The mice in MI + UCMS group and MI + UCMS + ES group underwent UCMS for consecutive two weeks. There were four kinds of UCMS applied in this experiment, such as sound stress for 30 min, no sawdust for 24 h, dampened sawdust for 24 h, tilt cages at 45° against the wall for 30 min [ 20 – 22 ] (Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

Selective serotonin reuptake inhibitors regulate the interrelation between 5-HT and inflammation after myocardial infarction

Zhang

2023

BMC Cardiovasc Disord

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Background Acute myocardial infarction (AMI) is a main cause of death all around the world. There is a close relationship between myocardial infarction (MI) and depression. MI patients with untreated depression had higher mortality than those without depression. Therefore, this study aimed to explore the effect of escitalopram in treating a model under MI and unpredictable chronic mild stress (UCMS). Methods Male C57BL/6J mice were treated with sham surgery, or MI surgery, or UCMS, or escitalopram (ES) for a consecutive two weeks. And the mice were divided into Sham group, MI group, MI + UCMS group, MI + UCMS + ES group (n = 8 in each group). After treatment, the mice went through open field test for anxiety behavior, sucrose preference test for depressive behavior. After sacrificed, the blood, heart, hippocampus, and cortex were collected. Results The escitalopram badly increased the area of cardiac fibrosis size. The sucrose preference test demonstrated that escitalopram treatment showed significant effect in improving depressive behaviors of mice under MI + UCMS. The potential mechanism involved the interrelation between 5-HT system and inflammation. MI significantly affected the level of cardiac SERT. Both UCMS and ES significantly affected the level of cortex TNF-α. UCMS significantly affected the level of cardiac IL-33. In the hippocampus tissue, TNF-α was positively correlated with SERT, and IL-10 was positively correlated with SERT. In the cortex tissue, IL-33 was positively correlated with 5-HT4R, and sST2 was positively correlated with 5-HT. Conclusions Two-week escitalopram treatment might worsen myocardial infarction. But escitalopram could benefit depressive behaviors, which may be related with the interrelationship between the 5-HT system and inflammatory factors in the brain.

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Section: Methodsmentioning

confidence: 99%

Selective serotonin reuptake inhibitors regulate the interrelation between 5-HT and inflammation after myocardial infarction

Zhang

2023

BMC Cardiovasc Disord

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Are the promnestic effects of neurokinin 3 receptor mediated by hippocampal neurogenesis in a Aβ‐induced rat model of Alzheimer's disease?

Koca,

Gormus,

Solak

et al. 2024

Intl J of Devlp Neuroscience

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Alzheimer's disease (AD) is an age‐related neurodegenerative disorder characterised by cognitive dysfunction, memory loss and mood changes. Hippocampal neurogenesis has been suggested to play a role in learning and memory. Neurokinin 3 receptor (NK3R) has been shown to be prevalent in the hippocampus region. The aim of the project was to investigate the role of hippocampal neurogenesis in the promnestic effects of NK3R agonist administration in an amyloid beta‐induced AD rat model. Wistar albino rats were divided into control, Alzheimer, NK3R agonist and Alzheimer + NK3R agonist groups. The open field (OF) test and Morris water maze (MWM) test were performed for locomotor activity and memory analysis. Peptide gene expression levels (Nestin, DCX, Neuritin, MASH1, Neun, BDNF) were analysed by quantitative reverse transcription polymerase chain reaction (RT‐PCR). In the OF test, the group–time relationship was found to be statistically different in the parameters of distance travelled and percentage of movement (p < 0.05). In MWM, the time to reach the platform and the time spent in the target quadrant were statistically significant between the groups (p < 0.05). Statistically significant differences were observed in gene expression levels (Nestin, DCX, Neuritin, MASH1) in the hippocampal tissue of rats between the groups (p < 0.05). NK3 receptor agonism favourably affected hippocampal neurogenesis in AD model rats. It was concluded that NK3 receptor agonism in the hippocampus, which is the first affected region in the physiopathology of AD, may be effective in both the formation of neural precursor cells and the reduction of neuronal degeneration. The positive effect of NK3R on cognitive functions may be mediated by hippocampal neurogenesis.

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‘The effect of neuropeptide Y1 receptor agonist on hypothalamic neurogenesis in rat experimental depression model’

Solak,

Gormus,

Koca

et al. 2024

Metab Brain Dis

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Does Sertraline Affect Hypothalamic Food Intake Peptides in the Rat Experimental Model of Chronic Mild Stress-Induced Depression?

Cited by 4 publications

References 62 publications

Selective serotonin reuptake inhibitors regulate the interrelation between 5-HT and inflammation after myocardial infarction

Selective serotonin reuptake inhibitors regulate the interrelation between 5-HT and inflammation after myocardial infarction

Are the promnestic effects of neurokinin 3 receptor mediated by hippocampal neurogenesis in a Aβ‐induced rat model of Alzheimer's disease?

‘The effect of neuropeptide Y1 receptor agonist on hypothalamic neurogenesis in rat experimental depression model’

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