“Does serum estrogen level have an impact on outcomes in hormonal replacement frozen-warmed embryo transfer cycles?”

Garimella, Sita; Karunakaran, Sandeep; Gedela, Durga Rao

doi:10.1080/09513590.2021.1892631

Cited by 6 publications

(1 citation statement)

References 22 publications

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“…In assisted reproduction technology (ART) treatment of the frozen-thawed embryo transfer (FET) cycle, endometrial preparation is pharmacologically mimicked by hormone replacement treatment with estrogen and progesterone and monitored for the WOI-assessed endometrial thickness measured by ultrasonography and blood hormone levels [ 3 , 4 ]. These methods do not assess endometrial receptivity for objectivity and precision; therefore, a better way of objectively and reproducibly assessing endometrial receptivity is required.…”

Section: Introductionmentioning

confidence: 99%

A case of discrepancy between three ERA tests in a woman with repeated implantation failure complicated by chronic endometritis

Ota

Takahashi

Mitsui³

et al. 2022

BMC Pregnancy Childbirth

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Background Endometrial receptivity array (ERA) is used to determine the timing of embryo transfer (ET) synchronized with the window of implantation (WOI). The effectiveness and evaluation of ERAs in women with recurrent implantation failure remain controversial. We report the case of a patient with recurrent implantation failure that raises the issue of reproducibility of ERA tests. Case report A 36-year-old Japanese woman with secondary infertility who had previously given birth failed to conceive after three frozen-thawed embryo transfer (FET) cycles. An ERA test was conducted to confirm the WOI. The first ERA test was performed 125 h after progesterone exposure. The laboratory reported that the endometrium was in a non-receptive (post-receptive) phase, and recommended retesting 101 h after progesterone exposure. A simultaneous chronic endometritis (CE) test showed a score of 3. After the antibiotics administration to treat CE, the second ERA test was performed after 101 h of progesterone exposure. The laboratory reported that the endometrium had not reached the WOI and estimated the WOI to be 113 ± 3 h after progesterone exposure. The third ERA test was performed 113 h after progesterone exposure. The laboratory reported that the endometrium was in a non-receptive (pre-receptive) phase and estimated the WOI to be 137 ± 3 h after progesterone exposure. A CE test performed at the same time as the second and third ERA tests showed a score of 1 for the collected endometrium. According to the third ERA test results, the vitrified-warmed blastocyst was transferred at 137 h of progesterone exposure. Pregnancy was achieved and the patient had an uncomplicated vaginal delivery at 39 weeks. One year later, another pregnancy was achieved after FET at 137 h of progesterone exposure, and the patient delivered at 33 weeks due to an unexpected membrane rupture. Conclusion Because the results of the ERA test may vary in the presence of CE, CE should be diagnosed simultaneously with or before conducting ERA tests. If CE is diagnosed, ERA testing should be performed after treatment with antimicrobials or other drugs.

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Section: Introductionmentioning

confidence: 99%

A case of discrepancy between three ERA tests in a woman with repeated implantation failure complicated by chronic endometritis

Ota

Takahashi

Mitsui³

et al. 2022

BMC Pregnancy Childbirth

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Effect of estrogen exposure on pregnancy outcomes in artificial frozen-thawed embryo transfer cycles

Wei,

Wu,

et al. 2024

Gynecological Endocrinology

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The relationship between serum oestrogen levels and clinical outcomes of hormone replacement therapy-frozen embryo transfer: a retrospective clinical study

Kong

Liu

Zhang

et al. 2022

BMC Pregnancy Childbirth

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Background This study aimed to explore the relationship between serum oestrogen (E2) levels before endometrial transformation and pregnancy outcomes of hormone replacement therapy-frozen embryo transfer (HRT-FET) cycles, which has been investigated for years without any consensus. Methods A retrospective cohort study of 10,209 cycles HRT-FET cycles was conducted at the Reproductive Medicine Center of Nanjing Drum Tower Hospital from March 2017 to December 2020. A smooth fitting curve was constructed to identify the relationship between serum E2 levels before endometrial transformation and the clinical pregnancy rate. Then, threshold and saturation effect analysis was employed to explore the cut-off value of serum E2 levels. In addition, patients were divided into 2 groups based on their levels of serum E2 measured before progesterone-induced endometrial transformation: Group 1, < 300 pg/mL (n = 6251) and Group 2, ≥ 300 pg/mL (n = 3958). The clinical pregnancy and miscarriage rates of all groups were compared. Further smooth fitting curve analysis was employed by different subgroups segmented according to different endometrial thicknesses. Results When the serum E2 level was greater than 300 pg/mL, the clinical pregnancy rate decreased significantly (62.9% vs. 59.8%, p < 0.01), but the miscarriage rates were similar (13.5% vs. 15.6%, p = 0.14). While serum E2 level reached or exceeded 1400 pg/mL, there was no significant correlation between the clinical pregnancy rate and E2 level. The clinical pregnancy rate reached its higher level at lower E2 levels, regardless of the different endometrail thicknesses. Conclusions Patients with a lower pretransformation serum E2 level (less than 300 pg/mL) have a higher clinical pregnancy rate and there was no correlation between the clinical pregnancy rate and a higher serum E2 level (greater than 1400 pg/mL) in HRT-FET cycles.

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“Does serum estrogen level have an impact on outcomes in hormonal replacement frozen-warmed embryo transfer cycles?”

Cited by 6 publications

References 22 publications

A case of discrepancy between three ERA tests in a woman with repeated implantation failure complicated by chronic endometritis

A case of discrepancy between three ERA tests in a woman with repeated implantation failure complicated by chronic endometritis

Effect of estrogen exposure on pregnancy outcomes in artificial frozen-thawed embryo transfer cycles

The relationship between serum oestrogen levels and clinical outcomes of hormone replacement therapy-frozen embryo transfer: a retrospective clinical study

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