Does Side of Onset Influence the Pattern of Cerebral Atrophy in Parkinson’s Disease?

Santos, Maria Carolina dos; Campos, Lidiane; Guimarães, Rachel; Piccinin, Camila; Azevedo, Paula; Piovesana, Luiza; Campos, Brunno Machado de; Amato-Filho, Augusto; Cendes, Fernando; D’Abreu, Anelyssa

doi:10.3389/fneur.2016.00145

Cited by 11 publications

(4 citation statements)

References 26 publications

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“…Our total PD sample demonstrated smaller GMV in the left hemisphere in stages 1 + 2, which was independent of the MAH DaT . This finding accords with previous studies that found left‐hemisphere‐dominant atrophy, which was not influenced by the dominant side of motor symptoms 53,54 . It is tempting to speculate that the left hemisphere is particularly susceptible to atrophy, whereby gray matter changes in the left hemisphere may be more pronounced specifically in the early stages of the disease 54‐57 .…”

Section: Discussionsupporting

confidence: 91%

“…This finding accords with previous studies that found left-hemispheredominant atrophy, which was not influenced by the dominant side of motor symptoms. 53,54 It is tempting to speculate that the left hemisphere is particularly susceptible to atrophy, whereby gray matter changes in the left hemisphere may be more pronounced specifically in the early stages of the disease. [54][55][56][57] Although there is also contradictory evidence to this account, it seems that this vulnerability of the left hemisphere is also shared by other neurodegenerative disorders.…”

Section: Discussionmentioning

confidence: 99%

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Gray Matter Volume Loss in Proposed Brain‐First and Body‐First Parkinson's Disease Subtypes

et al. 2022

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Background α‐Synuclein pathology is associated with neuronal degeneration in Parkinson's disease (PD) and considered to sequentially spread across the brain (Braak stages). According to a new hypothesis of distinct α‐synuclein spreading directions based on the initial site of pathology, the “brain‐first” spreading subtype would be associated with a more asymmetric cerebral and nigrostriatal pathology than the “body‐first” subtype. Objective Here, we tested if proposed markers of brain‐first PD (ie, higher dopamine transporter [DaT] asymmetry; absence of rapid eye movement sleep behavior disorder [RBD]) are associated with a greater or more asymmetric reduction in gray matter volume (GMV) in comparison to body‐first PD. Methods Data of 255 de novo PD patients and 110 healthy controls (HCs) were retrieved from the Parkinson's Progression Markers Initiative. Structural magnetic resonance images were preprocessed, and GMVs and their hemispherical asymmetry were obtained for each of the neuropathologically defined Braak stages. Group and correlation comparisons were performed to assess differences in GMV and GMV asymmetry between PD subtypes. Results PD patients demonstrated significantly smaller bilateral GMVs compared to HCs, in a pattern denoting stage‐dependent disease‐related brain atrophy. However, the degree of putaminal DaT asymmetry was not associated with reduced GMV or higher GMV asymmetry. Furthermore, RBD‐negative and RBD‐positive patients did not demonstrate a significant difference in GMV or GMV asymmetry. Conclusions Our findings suggest that putative brain‐first and body‐first patients do not present diverging brain atrophy patterns. Although certainly not disproving the brain‐first/body‐first spreading hypothesis, this study fails to provide evidence in support of it. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Gray Matter Volume Loss in Proposed Brain‐First and Body‐First Parkinson's Disease Subtypes

et al. 2022

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“…We found that 75.64% of patients had an upper limb onset, which was in line with the literature [24] . Imaging studies reported the side of onset might in uence the pattern of cerebral atrophy in PD [25] , however, whether the side of onset affects the progression of PD had not been reported. In agreement with another literature, our study showed that mixed subtype was regarded as the commonest type [26,27] , and the number of patients with akinetic-rigid subtype who were at ES was the smallest, while the results were reversed in mixed subtype patients at AS (Table 1).…”

Section: Overall Characteristics Of 193 Pd Patientsmentioning

confidence: 99%

Risk Factors of Non-motor Symptoms in Different Stages of Parkinson’s Disease

Jiang,

Jin,

et al. 2023

Preprint

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Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder and non-motor symptoms can affect the treatment nature of PD. Aims: To investigate the clinical features and NMSs at different Hoehn and Yahr (H&Y) stages among patients with PD, and the risk factors of common NMSs. Methods: We collected the clinical characteristics of 193 PD patients and used binary logistic regression analysis to evaluate the risk factors of NMSs among three groups based on H&Y stage. Results: The results showed that 87.05% of PD patients had more than one NMS. Clinical features varied across three groups including disease duration, right upper limb onset, motor subtypes, antiparkinson drugs administration and Levodopa equivalent daily dose (LEDD). Autonomic disorders were the most common NMSs in which the prevalence of constipation was the highest. For risk factors of NMSs, antiparkinson drugs were dominant. Longer disease duration was a risk factor for pain and urinary dysfunction at early stage, respectively. Gender and LEDD by disease duration might be associated with depression and orthostatic hypotension at intermediate stage, respectively. Conclusions: Pain and constipation were the most common NMSs in PD patients. Chinese PD patients often turn to Chinese Medicine, especially acupuncture, to treat NMSs such as pain. Our study will help clinicians to accurately judge the possibility of PD patients developing certain NMSs and their risk factors at different H&Y stage, and to guide medication regimen to a certain extent, so as to better manage patients.

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“…Former studies suggested that the compensatory mechanisms in the dominant hemisphere of brain may be an underlying explanation [7,8]. Neuroimaging studies have found that PD patients with different onset or more affected sides showed distinct image features [7,10], suggesting differences in the degenerative patterns between two hemispheres during the progression of the disease. The corpus callosum (CC) is the largest ber bundle that connects two hemispheres and projects to different functional brain areas.…”

Section: Introductionmentioning

confidence: 99%

Microstructural degeneration of the corpus callosum in Parkinson’s disease with unilateral onset: A free-water imaging study

Chen,

Wu,

Zhou

et al. 2024

Preprint

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Background The laterality of motor symptoms is an important clinical feature of PD, which is not only manifested as the lateral dysfunctions of limbs but also affects the non-motor symptoms and the prognosis in PD patients. Former studies suggested that the compensatory mechanisms in the dominant hemisphere of brain may be an underlying explanation. The corpus callosum (CC) is the largest fiber connecting the two hemispheres of brain. Considering CC as the pointcut may help to explore the mechanism of the laterality of motor symptoms affecting the non-motor symptoms and prognosis in PD patients. Purpose To explore microstructural degeneration of CC in PD patients with unilateral motor symptoms onset based on the bi-tensor model of diffusion imaging technology, and further explore the relationship with motor and non-motor performance. Methods A total of 201 right-handed PD patients with unilateral motor symptoms onset were included in this study, including 91 patients with left-onset (LPD) and 110 with right-onset (RPD), as well as 100 right-handed healthy controls (HC). A bi-tensor model of diffusion tensor imaging (DTI) was applied to obtain free-water (FW), as well as fractional anisotropy (FAT) and mean diffusivity (MDT) after correcting free-water. CC was divided into halves by the median sagittal line, and each was further divided into five functional segments manually according to the specific template. A total of 10 subregions were obtained and numbered in sequence. The laterality index (LI) was calculated to quantify the asymmetry of CC and its segments. The general linear model was used for the comparisons among groups, and then partial correlation analysis was performed to explore the relationship between the diffusion parameters of CC subregions and clinical manifestations. Results Compared with HC, FW and FAT of CC in bilateral hemispheres were decreased in LPD group, while MDT in right hemisphere was increased. In LPD group, FAT of all CC subregions except for subregions 1, 3 and 6 were significantly lower than HC, and MDT in anterior and posterior segments of CC (CC subregions 1, 5, 6, 7 and 10) were significantly higher than HC. In RPD group, FAT of subregion 7 was significantly decreased and MDT was increased than HC. The LI analysis of CC reflected significant interhemispheric FAT asymmetry of the anterior and middle segments of CC in RPD group, with a more significant reduction in the right hemisphere of CC. Moreover, the degeneration in CC and its subregions was related to motor or non-motor symptoms in PD. Conclusions Extensive damage of CC was observed in LPD group than in RPD group, while asymmetrical damage was found in the anterior and middle segments of CC in RPD group, suggesting that differences in the patterns of callosal degeneration may be one of the potential mechanisms of asymmetrical motor symptoms affect the non-motor symptoms and prognosis in PD.

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Does Side of Onset Influence the Pattern of Cerebral Atrophy in Parkinson’s Disease?

Cited by 11 publications

References 26 publications

Gray Matter Volume Loss in Proposed Brain‐First and Body‐First Parkinson's Disease Subtypes

Gray Matter Volume Loss in Proposed Brain‐First and Body‐First Parkinson's Disease Subtypes

Risk Factors of Non-motor Symptoms in Different Stages of Parkinson’s Disease

Microstructural degeneration of the corpus callosum in Parkinson’s disease with unilateral onset: A free-water imaging study

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