Does Single-Dose Preemptive Intravenous Ibuprofen Reduce Postoperative Pain After Third Molar Surgery? A Prospective, Randomized, Double-Blind Clinical Study

Demirbaş, Ahmet Emin; Karakaya, Mustafa; Bilge, Şuheyb; Canpolat, Dilek Günay; Kütük, Nükhet; Alkan, Alper

doi:10.1016/j.joms.2019.04.019

Cited by 22 publications

(42 citation statements)

References 27 publications

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“…-Visual Analog Scale (VAS) Participants have completed a visual analogue scale (VAS), where they indicated the presence and intensity of pain (20,21). This scale has 10 cm of lenght, subdivided into five equal parts, where one end corresponds to no pain (0), and the other end to severe pain (10,22). The registry was completed by all participants at the following times: 1, 6, 12, 24, 48 and 72 hours post-surgery.…”

Section: Methodsmentioning

confidence: 99%

Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled clinical trial

Pereira¹,

Cota²,

Lima³

et al. 2020

J Clin Exp Dent

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Background: Preemptive analgesia has as its basic principle the administration of analgesics before the onset of painful stimuli, in order to reduce or prevent postoperative pain, but this question is little explored in implantology. Thus, this study was conducted in order to evaluate the clinical efficacy of ibuprofen in pain prevention after unit implant surgery. Material and Methods: For this triple-blind, parallel, placebo-controlled and randomized clinical trial, 54 insertion surgeries of unitary implants were performed. Two groups have received two different protocols 1 hour before surgery: Ibuprofen group (IBU) 600 mg of ibuprofen; and (2) placebo group (maize starch). The intensity of the pain was evaluated through the visual analogue scale (VAS) in 6 times (1, 6, 12, 24, 48 and 72 hours after the surgery). Patients were instructed to take 750 mg of paracetamol as rescue medication, if necessary. The occurrence and the intensity of pain were analyzed by means of an analysis of variance ANOVA with repeated measurements using the general linear model procedure. Results: The IBU group had significantly lower VAS scores overall (IBU = 0.30, ± 0.57; placebo = 1.14, ± 1.07; p<0.001) and at all times in the intra, intergroup comparisons and time/group interaction than the placebo group (p< 0.001). The use of rescue medication was significantly lower and the postoperative time was longer in the IBU group compared to placebo (p = 0.002). Conclusions: The single use of ibuprofen was found to be significantly superior in reducing pain after unit implant surgery compared to placebo.

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Section: Methodsmentioning

confidence: 99%

Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled clinical trial

Pereira¹,

Cota²,

Lima³

et al. 2020

J Clin Exp Dent

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“…Propionic acid derivatives Ibuprofen [9,[12][13][14]39,47,48], ketoprofen [27], Dexketoprofen [26,28].…”

Section: Nomentioning

confidence: 99%

“…Intravenous Ibuprofen [9,[12][13][14], acetaminophen [13], dipyrone [16], tramadol [23,32,37,38], dexamethasone [24], dexketoprofen [28], tenoxicam [29], methylprednisolone [29], lornaxicam [31], ketotolac [32,49], diclofenac [37]. 4.…”

mentioning

confidence: 99%

Pre-emptive analgesic efficacy of injected ketorolac in comparison to other agents for third molar surgical removal: a systematic review

Tirupathi

Rajasekhar²,

Maloth

et al. 2021

J Dent Anesth Pain Med

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This study aimed to evaluate and compare the pre-emptive analgesic efficacy of injected ketorolac to that of other agents for impacted third molar surgical removal in a healthy population. PubMed, Ovid SP, Cochrane databases were filtered from 1980 to July 2020 for potential papers using relevant MeSH terms and pre-specified inclusion and exclusion criteria independently by reviewers. Studies that compared pre-emptive intramuscular or intravenous administration of ketorolac to other agents were evaluated. The outcomes sought were self-reported postoperative pain (patient-perceived pain), median duration for rescue analgesic medication, total number of analgesics consumed in the recovery period, and global assessment (overall patient satisfaction) after the recovery period. Six studies were included in the final evaluation. The outcome of pain perception and the number of analgesics taken were significantly lower in the ketorolac group (intramuscular or intravenous) in most of the studies (n=5) than in the group of other drugs. The mean time for rescue analgesia intake was higher for the ketorolac group, and global assessment scores were also better in the ketorolac group. Although the included studies show significantly better outcomes such as postoperative pain, median time taken for rescue medication, total number of analgesics taken, and overall patient satisfaction with injected ketorolac group in comparison to injected diclofenac, dexamethasone, and tramadol, definitive conclusions cannot be made regarding the superiority of injected Ketorolac as a pre-emptive agent. A greater number of randomized control trials with a proper protocol are needed to make definitive conclusions.

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“…Preemptive analgesia is the concept of a preoperative antinociceptive approach that prevents or modulates postoperative pain (5,6). Preemptive analgesia using non-steroidal anti-inflammatory drugs (NSAIDs) in third molar surgeries has been effective (7)(8)(9).…”

Section: ' Introductionmentioning

confidence: 99%

Preemptive use of intravenous ibuprofen to reduce postoperative pain after lower third molar surgery: a systematic review of randomized controlled trials

Silva

Meneses-Santos

Vieira

et al. 2021

Clinics

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Does Single-Dose Preemptive Intravenous Ibuprofen Reduce Postoperative Pain After Third Molar Surgery? A Prospective, Randomized, Double-Blind Clinical Study

Cited by 22 publications

References 27 publications

Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled clinical trial

Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled clinical trial

Pre-emptive analgesic efficacy of injected ketorolac in comparison to other agents for third molar surgical removal: a systematic review

Preemptive use of intravenous ibuprofen to reduce postoperative pain after lower third molar surgery: a systematic review of randomized controlled trials

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