Does slow embryo development predict a high aneuploidy rate on trophectoderm biopsy?

Extended culture of poor-quality supernumerary embryos improves ART outcomes

“…Our results are in line with those of Haas et al who recently demonstrated that clinical pregnancy rates following frozen embryo transfer is higher with blastocysts frozen on day 5 than on day 6 [23]. Impaired implantation of slow developing cleavage stage embryos may be linked to high rates of aneuploidy in day-6 embryos [24] especially in older women [25].…”

Elective single blastocyst transfer in advanced maternal age

“…A recent study has shown that EBs that became FEBs on day 6 were less likely to be euploid compared to FEBs on day 5 (23 vs. 41%, p < 0.05) [23]. A second study demonstrated similar results, with a higher aneuploidy rate of EBs compared to those of FEBs (70 vs. 61%, p < 0.05) [24]. However, other studies showed similar aneuploidy rates between day 5 and day 6 FEBs [15,22].…”

Blastocyst culture in the Era of PGS and FreezeAlls: Is a ‘C’ a failing grade?

“…Although there was a trend to increased live birth rate with Day 5 blastocysts, this effect was lost when the analysis included blastocyst quality. More recent studies indicate that Day 5 blastocysts may be superior to Day 6 blastocysts, although this difference appears to be lost when euploid embryos are transferred (Capalbo et al , 2014; Piccolomini et al , 2016). The developmental potential of Day 7 blastocysts relative to Day 5/6 blastocysts is likely reduced but the data available are limited (Richter et al , 2006; Hiraoka et al , 2009; Kovalevsky et al , 2013).…”

“…Inclusion of grade ‘C’ blastocysts adds an additional layer of uncertainty in the context of Day 7 blastocysts and requires careful consideration. Furthermore, since slow development in older patients is associated with higher aneuploidy rates (Campbell et al , 2014; Piccolomini et al , 2016), guidelines for freezing slow growing blastocysts should be relative to age.…”