Does speciation matter for tungsten ecotoxicology?

Strigul, Nikolay

doi:10.1016/j.ecoenv.2010.05.005

Cited by 75 publications

(48 citation statements)

References 191 publications

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“…The low pH in gastric juice will favor polytungstate formation, but the ambient low concentrations of tungstate in the stomach is expected to limit polytungstate formation. This finding has important implications for tungsten toxicity since phosphotungstate is a well-established redox catalyst 2,13 . It is also a new mechanism for the in vivo toxification of a soluble metal with the other recognized mechanism being metal methylation 14 .…”

Section: Resultsmentioning

confidence: 96%

“…The prevalent belief that it is innocuous, coupled with its many unique properties, has led to the pervasive adoption of tungsten in a surprising range of technologies 2,3 . However, the recent association of a cluster of acute childhood lymphocytic leukemia cases in Fallon, Nevada, with elevated levels of tungsten in the community's ground water 4 has led to a reappraisal of its potential toxicity.…”

mentioning

confidence: 99%

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Accumulation of persistent tungsten in bone as in situ generated polytungstate

et al. 2018

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Tungsten accumulates in bone but is neither labile nor inert once absorbed. Tungsten's relatively high cytosolic solubility and availability are problematic given its association with childhood lymphocytic leukemia. In light of tungsten's technological prevalence, and the increased concern of regulatory agencies, here we characterize the chemical form and localization in mice exposed to tungsten through drinking water. Using X-ray fluorescence spectroscopy, we report accumulation of tungsten in bone tissue with some sites having~10-fold greater intensities than background levels. The long bone tissue studied includes cortical, cancellous and bone marrow. Persistence of tungsten in cortical bone tissue following removal of the source indicates that it is retained in an insoluble form. The X-ray absorption near-edge structure spectra for tungsten in these tissues indicate that it is no longer in the originally administered form, orthotungstate, but rather resembles the heteropolytungsate species, phosphotungstate.

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Section: Resultsmentioning

confidence: 96%

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confidence: 99%

Accumulation of persistent tungsten in bone as in situ generated polytungstate

et al. 2018

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“…Tungsten compounds can be released into the environment by industrial processes, coal combustion, vehicle tires, agricultural fertilizers, and military activities [75]. Monotungstates are not very toxic but become so in the form of polyoxotungstates [75].…”

Section: Tungstenmentioning

confidence: 99%

“…Monotungstates are not very toxic but become so in the form of polyoxotungstates [75]. To date, few biomonitoring studies involving tungsten have been conducted.…”

Section: Tungstenmentioning

confidence: 99%

Internal Exposure to Trace Elements in Non-smoking Residents Living in a Northern Taiwan Industrial City

Lin

2011

Biol Trace Elem Res

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A total of 94 (54 males, 40 females) healthy adult residents living in an industrial city in northern Taiwan were recruited to study their exposure to industrial metals by measuring their blood levels of V, Cr, Mn, Ni, Co, As, Se, Mo, Cd, Pb, and W. All participants were non-smokers without obvious direct occupational exposure to these elements, although by working in administrative sectors in industrial facilities their indirect or potential exposure was increased. The average concentrations of V, Cr, Mn, Ni, Co, As, Se, Mo, Cd, Pb, and W in blood were 0.30, 1.49, 15.1, 3.84, 2.73, 21.1, 204, 3.2, 0.76, 51.1, and 0.40 ng/mL, respectively. These values were significantly higher than reference values reported for the general population, in some cases exceeding those of occupationally exposed workers. The principal component and correlation analyses among blood element levels suggested that the predominant sources of exposure were glass manufacturing and traffic-related sources. Despite of some limitations, the study demonstrates that the residents in this industrial area may suffer adverse chronic health effects attributable to exposures to these elements.

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“…8 However, the existing knowledge does not provide clear information regarding the behavior of W-based products in the environment. 1 Consequently, many studies have drawn attention to the limitation of environmental regulations for W in comparison with other metals 1,4,8 and the necessity of the reevaluation of W due to the historical view of it as a "nontoxic" and "environmentally inert" metal.…”

Section: 312mentioning

confidence: 99%

Development of a sample preparation strategy for the determination of tungsten in soil samples by inductively coupled plasma mass spectrometry using a response surface methodology

Erdemir¹

2017

Turk J Chem

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An alternative rapid digestion method has been developed for the determination of tungsten (W) in soil samples using fractionation studies and response surface methodology. The digestion method using the Kjeldahl instrument was applied to samples, and soluble tungsten was determined via inductively coupled plasma mass spectrometry. Digestion parameters were selected depending on the results of fractionation studies and optimized using a four-factor and five-level central composite design. The contributions of the phosphoric acid concentration (X 1) , digestion temperature (X 2) , digestion time (X 3) , and hydrochloric acid concentration (X 4) were evaluated for the determination of W from samples in which its levels were maximum. Optimum conditions for factors were found to be X 1 = 9.00 M, X 2 = 124 • C, X 3 = 45 min, and X 4 = 1.52 M using a predicted W level of 86.82 µ g L −1 . This yielded an expected level of 1736.40 mg kg −1 under the optimized conditions. Experimental W levels were in good agreement with this predicted level and found to be 1682.69 mg kg −1 . Thus, measured W levels showed the versatility of the central composite design in such a complex soil matrix for method development.

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Does speciation matter for tungsten ecotoxicology?

Cited by 75 publications

References 191 publications

Accumulation of persistent tungsten in bone as in situ generated polytungstate

Accumulation of persistent tungsten in bone as in situ generated polytungstate

Internal Exposure to Trace Elements in Non-smoking Residents Living in a Northern Taiwan Industrial City

Development of a sample preparation strategy for the determination of tungsten in soil samples by inductively coupled plasma mass spectrometry using a response surface methodology

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