Does sperm DNA fragmentation correlate with semen parameters?

Lê, Minh Tâm; Nguyen, Tam An Thi; Nguyen, Hiep Tuyet Thi; Nguyen, Thai Thanh Thi; Nguyen, Van Toan; Le, Dinh Duong; Nguyen, Vu Quoc Huy; Cao, Ngọc Thành

doi:10.1002/rmb2.12297

Cited by 56 publications

(50 citation statements)

References 31 publications

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“…Similarly, idiopathic male infertility, a term given to describe men with one or more abnormality in semen parameters without an identifiable etiology, has been associated with high SDF. Studies have confirmed a significant inverse correlation between the SDF level and sperm count, motility and normal morphology [140,186,187]. A few comparative studies also have revealed that men with idiopathic male infertility tend to have significantly higher SDF than normal fertile controls [188] (Table 2).…”

Section: Idiopathic and Unexplained Male Infertilitymentioning

confidence: 85%

Sperm DNA Fragmentation: A New Guideline for Clinicians

Agarwal

Majzoub

Baskaran

et al. 2020

World J Mens Health

185

144

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Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abortive apoptosis) and post-testicular (oxidative stress) mechanisms are implicated in the etiology of sperm DNA fragmentation (SDF), which affects both natural and assisted reproduction. Several clinical and environmental factors are known to negatively impact sperm DNA integrity. An increasing number of reports emphasizes the direct relationship between sperm DNA damage and male infertility. Currently, several assays are available to assess sperm DNA damage, however, routine assessment of SDF in clinical practice is not recommended by professional organizations. This article provides an overview of SDF types, origin and comparative analysis of various SDF assays while primarily focusing on the clinical indications of SDF testing. Importantly, we report four clinical cases where SDF testing had played a significant role in improving fertility outcome. In light of these clinical case reports and recent scientific evidence, this review provides expert recommendations on SDF testing and examines the advantages and drawbacks of the clinical utility of SDF testing using Strength-Weaknesses-Opportunities-Threats (SWOT) analysis.

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Section: Idiopathic and Unexplained Male Infertilitymentioning

confidence: 85%

Sperm DNA Fragmentation: A New Guideline for Clinicians

Agarwal

Majzoub

Baskaran

et al. 2020

World J Mens Health

185

144

View full text Add to dashboard Cite

show abstract

“…Altered sperm DNA structure may be a contributor to male infertility and is not characterized by typical sperm parameters, such as those discussed in the sections above. As a result, sperm DNA abnormalities can be expressed as the DFI with a DFI > 30% considered abnormal [ 20 ]. Increased DNA fragmentation has not been shown to correlate with conventional semen parameters when using Sperm Chromatin Dispersion (SCD) assays [ 20 ].…”

Section: How Do Paternal Factors Such Total Motile Count Post-wash Smentioning

confidence: 99%

“…As a result, sperm DNA abnormalities can be expressed as the DFI with a DFI > 30% considered abnormal [ 20 ]. Increased DNA fragmentation has not been shown to correlate with conventional semen parameters when using Sperm Chromatin Dispersion (SCD) assays [ 20 ]. Furthermore, while high DFIs reflect sperm DNA alterations, clinical studies assessing the correlation of DFI determined by SCD with pregnancy rates in IUI cycles show conflicting data.…”

Section: How Do Paternal Factors Such Total Motile Count Post-wash Smentioning

confidence: 99%

Predictive factors for intrauterine insemination outcomes: a review

Starosta

Gordon

Hornstein

2020

Fertil Res and Pract

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Purpose Intrauterine insemination (IUI) is a frequently utilized method of assisted reproduction for patients with mild male factor infertility, anovulation, endometriosis, and unexplained infertility. The purpose of this review is to discuss factors that affect IUI outcomes, including infertility diagnosis, semen parameters, and stimulation regimens. Methods We reviewed the published literature to evaluate how patient and cycle specific factors affect IUI outcomes, specifically clinical pregnancy rate, live birth rate, spontaneous abortion rate and multiple pregnancy rate. Results Most data support IUI for men with a total motile count > 5 million and post-wash sperm count > 1 million. High sperm DNA fragmentation does not consistently affect pregnancy rates in IUI cycles. Advancing maternal and paternal age negatively impact pregnancy rates. Paternal obesity contributes to infertility while elevated maternal BMI increases medication requirements without impacting pregnancy outcomes. For ovulation induction, letrozole and clomiphene citrate result in similar pregnancy outcomes and are recommended over gonadotropins given increased risk for multiple pregnancies with gonadotropins. Letrozole is preferred for obese women with polycystic ovary syndrome. IUI is most effective for women with ovulatory dysfunction and unexplained infertility, and least effective for women with tubal factor and stage III-IV endometriosis. Outcomes are similar when IUI is performed with ovulation trigger or spontaneous ovulatory surge, and ovulation may be monitored by urine or serum. Most pregnancies occur within the first four IUI cycles, after which in vitro fertilization should be considered. Conclusions Providers recommending IUI for treatment of infertility should take into account all of these factors when evaluating patients and making treatment recommendations.

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“…Sperm DNA damage can occur at the level of testicles, epididymis or after ejaculation (Lewis & Aitken, 2005). A decrease in sperm DNA integrity can be caused by environmental conditions such as cigarette smoking (Le et al, 2019;Potts, Newbury, Smith, Notarianni, & Jefferies, 1999), irradiation (Arnon, Meirow, Lewis-Roness, & Ornoy, 2001), chemotherapy (Morris, 2002), alcohol consumption (Le et al, 2019) and environmental toxins (Zini & Libman, 2006).…”

Section: Sources Of Sperm Dna Damagementioning

confidence: 99%

Diagnostic value of advanced semen analysis in evaluation of male infertility

2020

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Couples who are unable to conceive within a year of regular, unprotected sexual intercourse are recommended to seek evaluation. In about 40% of the couples, infertility is caused by a male factor and by both partners in an additional 20% of couples. The underlying causes for male infertility are multifactorial, with about 20% of these cases being idiopathic (Ayaz et al., 2015; Louis et al., 2013). 1.1 | Overview of semen analysis and its implications According to the guidelines of the World Health Organization (WHO, 2010), the clinical evaluation of male patients includes a medical history, physical examination and at least two semen analyses. The conventional semen analysis is very important in identifying the severity of male factor infertility and guiding future analysis and treatment (Agarwal & Bui, 2017). It further includes the determination of volume, pH, colour, viscosity, liquefaction time, number of round cells, sperm total count, concentration, motility and normal sperm morphology. 1.2 | Limitations of semen analysis in predicting fertility status Although standard semen analysis remains the standard of care to initially evaluate male patients with infertility, a routine semen analysis does not accurately identify the aetiology of infertility or predict the reproductive success (Snow-Lisy & Sabanegh, 2013). Routine semen analysis yields variable results due to inter-and intra-observer variability, and it gives no information about sperm dysfunctions at cellular and molecular levels (Agarwal & Bui, 2017; Esteves, 2014). Moreover, the lower reference limits established by the WHO are not applicable to all men as values of semen parameters overlap in fertile and infertile men. Therefore, the exact cause of idiopathic and unexplained male infertility remains unknown, even after performing routine semen analysis (Hamada, Esteves, & Agarwal, 2011; Wallach et al., 1983). Normal semen parameters do not equate with a normal fertilisation potential of spermatozoa (Hamada et al., 2011; Lewis, 2007). As a consequence, more advanced tests are needed to accurately diagnose male infertility and predict pregnancy in couples trying to conceive naturally or couples undergoing assisted reproductive technologies (ART; Oehninger, Franken, & Ombelet, 2014).

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Does sperm DNA fragmentation correlate with semen parameters?

Cited by 56 publications

References 31 publications

Sperm DNA Fragmentation: A New Guideline for Clinicians

Sperm DNA Fragmentation: A New Guideline for Clinicians

Predictive factors for intrauterine insemination outcomes: a review

Diagnostic value of advanced semen analysis in evaluation of male infertility

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