This review aimed to summarize empirical evidence concerning to the factors relating to medication adherence among patients with schizophrenia. A comprehensive search was implemented to recruit articles which met the present eligibility criteria. Twenty articles were included, all of which were quantitative studies. Greater awareness of
illness (insight), previous history of medication adherence, positive attitude toward medication, types of atypical antipsychotics, less severe psychotic symptoms, and social support, self-efficacy, general health status, gender men, lower socioeconomic status, living alone, length of illness, drug abuse, education level, severity of illness for example being in the acute phase, participating in mental health services, health facilities, marital status, receiving monotherapy were identified as factors of medication adherence. Implications to clinical practice include providing psychoeducation to patients and family by increasing their knowledge about illness and medication.