2015
DOI: 10.3371/csrp.faca.030813
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Does Systemic Inflammation Play a Role in Pediatric Psychosis?

Abstract: Context Human and animal studies have suggested an underlying inflammatory mechanism for a variety of neuropsychiatric disorders, including schizophrenia. To date, most available reports focused on adult patients. Objective We wished to test the hypothesis that the first psychotic episode in youth is associated with inflammation. Patients We studied patients admitted to a pediatric inpatient psychiatric unit. Patients (n=80) had new-onset psychosis diagnosed using DSM-IV TR criteria for Psychosis NOS, Schi… Show more

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Cited by 39 publications
(28 citation statements)
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“…Plasma and CSF levels of MCP‐1 and YKL‐40 were found not to correlate, and CSF levels of these chemokines did not differ between patients and controls. The novel finding of increased levels of plasma MCP‐1 and YKL‐40, as well as the replication of earlier reports of increased numbers of monocytes , strengthens the notion that innate immune activation is associated with early onset psychosis.…”
Section: Discussionsupporting
confidence: 78%
See 1 more Smart Citation
“…Plasma and CSF levels of MCP‐1 and YKL‐40 were found not to correlate, and CSF levels of these chemokines did not differ between patients and controls. The novel finding of increased levels of plasma MCP‐1 and YKL‐40, as well as the replication of earlier reports of increased numbers of monocytes , strengthens the notion that innate immune activation is associated with early onset psychosis.…”
Section: Discussionsupporting
confidence: 78%
“…When activated, monocytes differentiate into macrophages and dendritic cells in peripheral tissues , both sharing functional similarities with microglia in many aspects, such as phagocytosis, cellular morphology, production and release CD14, MHC molecules, and chemokine receptors . An increased number of circulating peripheral blood monocytes has previously been reported in schizophrenia , as well as in cerebrospinal fluid (CSF) during acute psychotic episodes . The expression of several pro‐inflammatory genes (e.g.…”
Section: Introductionmentioning
confidence: 99%
“…In previous publications we have reported the relationship of S100B to clinical symptoms such as suicidality (Falcone et al, 2010) and psychosis in a smaller sample of children and adolescents (Falcone et al, 2013). Patients, who had suicidal ideation or behavior as measured by the BPRS-C suicidality sub-score, had increased levels of S100B (Falcone et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…In a similar study evaluating intensity and severity of suicidal ideation in adolescents as measured by the Columbia Suicide Severity Rating Scale (CSSRS), patients who were having increased intensity and severity of suicidal ideation had increased levels of S100B (Bruce et al, 2010). In a group of adolescent patients with first episode psychosis, levels of S100B and monocyte counts were elevated (Falcone et al, 2009; Bruce et al, 2010; Falcone et al, 2013). …”
Section: Introductionmentioning
confidence: 99%
“…Schizophrenia is also comorbid with medical conditions such as diabetes (adjusted OR: 2.11 (1.36 to 3.28) [11], overweight or obesity (44%) [12] and cardiovascular events [13]. Schizophrenia as well as bipolar disorder are part of a multisystem inflammatory processes [14] and anti-inflammatory therapy for treating schizophrenia is suggested [15]. …”
Section: Introductionmentioning
confidence: 99%