Does the ability to sustain attention underlie symptom severity in schizophrenia?

O’Gráda, Cara; Barry, Sandra; McGlade, Nicola; Behan, Caragh; Haq, Farhan; Hayden, Judy A.; O'Donoghue, Thérèse; Peel, Rosie; Morris, Derek W.; O’Callaghan, Eadbhard; Gill, Michael; Corvin, Aiden; Dinan, Timothy G.; Donohoe, Gary

doi:10.1016/j.schres.2008.07.013

Cited by 24 publications

(29 citation statements)

References 24 publications

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“…Brébion [44] suggested that selective attention disorder in schizophrenia patients might reduce reality-differentiating capacity, leading to hallucinations and delusions. Besides, another study revealed a positive correlation between negative symptoms severity and attention disorder [45]. In addition, some studies also showed that the attention disorder found in schizophrenia patients might exhibit disease specificity to a certain degree [46]–[47].…”

Section: Discussionmentioning

confidence: 94%

P300 Aberration in First-Episode Schizophrenia Patients: A Meta-Analysis

et al. 2014

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BackgroundDecreased P300 amplitude is one of the most consistent findings in patients with schizophrenia. However, whether prolonged P300 latency occurs in patients with schizophrenia, especially first-episode schizophrenia (FES) patients, remains controversial.MethodsA meta-analyses of P300 aberration in FES patients and healthy control(HC) group was conducted. The meta-regression analysis was performed using a random effects model. The pooled standardized effect size (PSES) was calculated as the division of the difference between the means of the two groups by the common standard deviation.ResultsA total of 569 FES patients and 747 HCs were included in this meta- analysis. P300 amplitude was significantly reduced (PSES = −0.83, 95% CI: −1.02–0.65, P = 0.00001) and P300 latency was delayed significantly in FES patients (PSES = −0.48, 95% CI: 0.14–0.81, P = 0.005). The meta-regression analysis showed that task difficulty was a source of heterogeneity.ConclusionsThe meta-analysis confirms that disrupted information processing is found in FES patients, which is manifested by smaller P300 amplitude and delayed P300 latency.

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Section: Discussionmentioning

confidence: 94%

P300 Aberration in First-Episode Schizophrenia Patients: A Meta-Analysis

et al. 2014

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“…Research in the field of schizophrenia indicates that negative symptoms are strongly associated to cognitive impairments, even if the precise nature of their relationship is still not fully established (Harvey et al, 2006). More specifically, negative symptoms have been associated with various cognitive domains, such as processing speed (Lipkovich et al, 2009;McDowd et al, 2011), working memory (Kebir & Tabbane, 2008;O'Gráda et al, 2009;Szendi et al, 2006), long-term memory (McDowd et al, 2011), executive functioning (Clark et al, 2010;Lewandowski et al, 2011), and attention (Sanz et al, 2012;Tsai et al, 2010). On the opposite, positive symptoms are thought to be largely independent of cognitive functioning (e.g.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Predominant negative symptoms in 22q11.2 deletion syndrome and their associations with cognitive functioning and functional outcome

Schneider

Linden

Menghetti

et al. 2014

Journal of Psychiatric Research

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Abstract22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic condition associated with increased risk for schizophrenia. No study do date has explored how positive and negative symptoms of psychosis are distributed among individual patients with 22q11.2DS and if distinct patterns of symptoms can be identified. Negative symptoms being more frequent than positive symptoms in 22q11.2DS, we expected that a high number of patients would display predominant negative symptoms (PNS), whereas predominant positive symptoms would be less frequently experienced.The present study aims at investigating the cognitive deficits and functional outcome associated with distinct patterns of psychotic symptoms in 22q11.2DS. 63 adolescents and young adults with 22q11.2DS participated in this study. Each participant underwent a clinical and a cognitive evaluation. A cluster analysis was used to identify groups of individuals with distinct patterns of symptoms. Individuals from the different clusters were then compared on a series of cognitive measures and on functional outcome. Three clusters of individuals were identified: low levels of symptoms, PNS, and high levels of symptoms. Individuals with PNS had significantly lower visual memory scores and decreased processing speed compared to participants with low levels of symptoms. They were also rated as having lower functional and occupational outcome. The present results indicate that one third of adolescents and young adults with 22q11.2DS display PNS. This pattern of symptoms was associated with specific cognitive deficits and decreased functional outcome. Future studies are needed to examine the developmental trajectories of these individuals and assess their risk of conversion to full-blown psychosis.

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“…In terms of clinical symptomatology, cognitive deficits are proposed to be more closely associated with negative and disorganised aspects of psychosis compared with positive symptoms (Bora and Murray, 2013;Dominguez et al, 2009). Attention, psychomotor speed and verbal learning in particular have been found to correlate with negative symptoms in schizophrenia (August et al, 2012;Bora and Murray, 2013;O'Gráda et al, 2009), while disorganised symptoms were related to lower verbal and visual learning, processing speed and social cognition (August et al, 2012;Flaum et al, 2000). Whether or not cognitive performance differs significantly between subtypes of psychosis, such as affective and non-affective subtypes, has not been determined conclusively.…”

Section: Introductionmentioning

confidence: 99%

Cognitive course in first-episode psychosis and clinical correlates: A 4 year longitudinal study using the MATRICS Consensus Cognitive Battery

Kenney

Anderson‐Schmidt

Scanlon

et al. 2015

Schizophrenia Research

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While cognitive impairments are prevalent in first-episode psychosis, the course of these deficits is not fully understood. Most deficits appear to remain stable, however there is uncertainty regarding the trajectory of specific cognitive domains after illness onset. This study investigates the longitudinal course of cognitive deficits four years after a first-episode of psychosis and the relationship of performance with clinical course and response to treatment.Twenty three individuals with psychotic illness, matched with 21 healthy volunteers, were assessed using the MATRICS Consensus Cognitive Battery at illness onset and 4 years later. We also investigated the relationship between cognitive deficits and quality of life and clinical indices.Verbal learning and two measures of processing speed had marked poorer trajectory over four years compared to the remaining cognitive domains. Processing speed performance was found to contribute to the cognitive deficits in psychosis. Poorer clinical outcome was associated with greater deficits at illness onset in reasoning and problem solving and social cognition. Cognitive deficits did not predict quality of life at follow-up, nor did diagnosis subtype differentiate cognitive performance.In conclusion, an initial psychotic episode may be associated with an additional cost on verbal learning and two measures of processing speed over a time spanning at least four years. Moreover, processing speed, which has been manipulated through intervention in previous studies, may represent a viable therapeutic target. Finally, cognition at illness onset may have a predictive capability of illness course.

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Does the ability to sustain attention underlie symptom severity in schizophrenia?

Cited by 24 publications

References 24 publications

P300 Aberration in First-Episode Schizophrenia Patients: A Meta-Analysis

P300 Aberration in First-Episode Schizophrenia Patients: A Meta-Analysis

Predominant negative symptoms in 22q11.2 deletion syndrome and their associations with cognitive functioning and functional outcome

Cognitive course in first-episode psychosis and clinical correlates: A 4 year longitudinal study using the MATRICS Consensus Cognitive Battery

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