Does the addition of clonidine affect duration of analgesia of bupivacaine wound infiltration in inguinal hernia surgery?

Abstract

We conducted a prospective, randomized, doubleblind study to compare analgesia obtained by wound infiltration using 29 ml of 0.25% bupivacaine alone, or with the addition of clonidine hydrochloride 150 g. A third group received bupivacaine wound infiltration with clonidine 150 g i.m. to control for the systemic effects caused by absorption of clonidine. We studied 46 adults undergoing elective inguinal hernia repair. The general anaesthetic technique, postoperative analgesia and wound infiltration technique were standardized. There was no difference in time to first analgesic request or to total analgesic consumption between the three groups during the 24-h study. Visual analogue scores (VAS) at rest and after coughing were noted over a 24-h period. The only difference was higher VAS scores at rest at 24 h in the control group who received i.m. clonidine. We conclude that for elective inguinal hernia repair, postoperative analgesia obtained by bupivacaine wound infiltration was not improved by the addition of clonidine 150 g. (Br.

Use of Clonidine as an Adjuvant to Infiltration Anaesthesia in Tympanoplasty: A Randomized Double Blind Study

“…The use of clonidine as an adjuvant to wound infiltration with local anaesthetics prior to elective hernia surgery has been cited in literature [11]. Doses up to 150 lg added to 0.5 % bupivacaine for wound infiltration did not reveal any improvement in duration of postoperative analgesia, though initial pain scores in the postoperative period were seen to be better in these patients.…”

The efficacy and safety of clonidine and dexmedetomidine as an adjuvant in supraclavicular brachial plexus block for elective upper limb surgery

“…α 2 agonists are safely used through various routes with promising effect as they prolong the duration of sensory and motor blockade, induced by local anesthetics irrespective of route of administration. [6][7][8] We had used clonidine and dexmedetomidine in a safe allowable doses to get maximum benefit. Keplinger et al studied different doses of dexmedetomidine with local anesthetics for peripheral nerve block, and found significant dose-dependent increase in the mean duration of analgesia [9] and Singelyn et al reported that a minimum dose of clonidine (0.5 µg/kg) added to mepivacaine prolongs the duration of anesthesia and analgesia in brachial plexus block.…”

“…[5] Our study was based on hypothesis that α 2 agonists as an adjuvant enhance the quality of block. [6][7][8] As there is a scarcity of studies comparing dexmedetomidine and clonidine in various doses, we compared dexmedetomidine 1 µg/kg and clonidine 1.5 µg/kg as adjuvants in supraclavicular brachial plexus block.…”

L’auto-administration de bupivacaïne ou de ropivacaïne au site d’incision procure une analgésie efficace a la suite d’une herniorraphie inguinale

“…The LA was injected into various layers of the surgical wound: under the fascia, 3,5 subcutaneously 11 and into the edges of the wound, 2,3,6,8-10 subcutaneously and into the muscle. 12 When added to the LA and used in single doses, NSAIDs 13 and clonidine 10 did not significantly prolong the duration of analgesia.…”