Does the association of child maltreatment with adult cardiovascular disease differ by gender?

Li, Leah; Lacey, Rebecca

doi:10.1136/heartjnl-2020-316991

Cited by 5 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, men have higher blood pressure during early adulthood, whereas females are normotensive, but when exposed to ELS, succumb to increased blood pressure [113,114]. Li et al found that women who have experienced physical abuse and/or emotional neglect had a significantly higher risk for ischemic heart disease and for CVD in general [115]. Albus et al report that microvascular dysfunction and vasospasm are associated with exposure to stress in women [1].…”

Section: Gendermentioning

confidence: 99%

H2S and Oxytocin Systems in Early Life Stress and Cardiovascular Disease

McCook

Denoix

Radermacher

et al. 2021

JCM

View full text Add to dashboard Cite

Today it is well established that early life stress leads to cardiovascular programming that manifests in cardiovascular disease, but the mechanisms by which this occurs, are not fully understood. This perspective review examines the relevant literature that implicates the dysregulation of the gasomediator hydrogen sulfide and the neuroendocrine oxytocin systems in heart disease and their putative mechanistic role in the early life stress developmental origins of cardiovascular disease. Furthermore, interesting hints towards the mutual interaction of the hydrogen sulfide and OT systems are identified, especially with regards to the connection between the central nervous and the cardiovascular system, which support the role of the vagus nerve as a communication link between the brain and the heart in stress-mediated cardiovascular disease.

show abstract

Section: Gendermentioning

confidence: 99%

H2S and Oxytocin Systems in Early Life Stress and Cardiovascular Disease

McCook

Denoix

Radermacher

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…The OT and H 2 S systems play sex-specific roles, and production of OT has been shown to vary between males and females [109]. The effect of ELS/ACE on the incidence or severity of subsequent COPD [204], as well as arterial hypertension, CHD, and cerebrovascular disease [205][206][207] was more pronounced in women, in contrast to the higher incidence of these conditions in men in the general population [208,209]. These epidemiological findings are complemented by recent data that the long-term outcome after TBI is worse in women than in men, particularly after "mild" TBI [210].…”

Section: Sexmentioning

confidence: 99%

Biological Connection of Psychological Stress and Polytrauma under Intensive Care: The Role of Oxytocin and Hydrogen Sulfide

Merz

McCook

Denoix

et al. 2021

IJMS

View full text Add to dashboard Cite

This paper explored the potential mediating role of hydrogen sulfide (H2S) and the oxytocin (OT) systems in hemorrhagic shock (HS) and/or traumatic brain injury (TBI). Morbidity and mortality after trauma mainly depend on the presence of HS and/or TBI. Rapid “repayment of the O2 debt” and prevention of brain tissue hypoxia are cornerstones of the management of both HS and TBI. Restoring tissue perfusion, however, generates an ischemia/reperfusion (I/R) injury due to the formation of reactive oxygen (ROS) and nitrogen (RNS) species. Moreover, pre-existing-medical-conditions (PEMC’s) can aggravate the occurrence and severity of complications after trauma. In addition to the “classic” chronic diseases (of cardiovascular or metabolic origin), there is growing awareness of psychological PEMC’s, e.g., early life stress (ELS) increases the predisposition to develop post-traumatic-stress-disorder (PTSD) and trauma patients with TBI show a significantly higher incidence of PTSD than patients without TBI. In fact, ELS is known to contribute to the developmental origins of cardiovascular disease. The neurotransmitter H2S is not only essential for the neuroendocrine stress response, but is also a promising therapeutic target in the prevention of chronic diseases induced by ELS. The neuroendocrine hormone OT has fundamental importance for brain development and social behavior, and, thus, is implicated in resilience or vulnerability to traumatic events. OT and H2S have been shown to interact in physical and psychological trauma and could, thus, be therapeutic targets to mitigate the acute post-traumatic effects of chronic PEMC’s. OT and H2S both share anti-inflammatory, anti-oxidant, and vasoactive properties; through the reperfusion injury salvage kinase (RISK) pathway, where their signaling mechanisms converge, they act via the regulation of nitric oxide (NO).

show abstract

“…e number of ACEs is also related to the presence of physical diseases. ese include ischemic heart disease, cancer, chronic obstructive pulmonary disease, bronchitis, emphysema, skeletal fractures, liver disease, diabetes, and migraine (Felitti et al, 1998;Felitti et al, 2019;Li & Lacey, 2020;Merrick et al, 2019;Pierce et al, 2020;Tietjen et al, 2012). e factors mentioned above may increase the likelihood of people with ACEs dying prematurely.…”

Section: Introductionmentioning

confidence: 99%

Adverse Childhood Experiences in Mexico: Prevalence and Association with Sociodemographic Variables and Health Status

Sánchez-Jáuregui,

Téllez,

Almaraz

et al. 2023

Psych. Rus.

View full text Add to dashboard Cite

Background. Adverse Childhood Experiences (ACEs) refer to a semantic field of negative childhood events that, in conjunction with insufficient personal, family, or contextual coping resources, have the potential of becoming traumatic. Objective. To assess the prevalence of Adverse Childhood Experiences (ACEs) and their association with sociodemographic variables and physical and mental illnesses in a Mexican sample. Design. A cross-sectional design was used. The sample included 917 Mexican adults who responded to the Adverse Childhood Experiences International Questionnaire (ACE-IQ). Most of the participants were female (79.3%) with an average age of 37 years, a monthly income between 500 and 2,500 USD (59.2%), had completed university education (45.6%) and were married or in a common-law marriage (53.1%). Data was collected through Google Forms, and the link to the form was shared through electronic social networks. Results. A total of 48.3% of the participants presented seven to nine types of ACEs. Among their responses, the most prevalent categories were emotional neglect (95.1%), family violence (83.3%), and emotional abuse (78.6%). A significant association was found between the number of ACEs and the mental illness diagnosis (x2(20) = 15.16; p < .001). Women were found to report more experiences of sexual abuse (z = -6.62, p < .001), whereas men reported more experiences of community violence (z = -4.27, p < .001) and collective violence (z = -3.94, p < .001). Conclusions. The prevalence of ACEs in the Mexican population is high. However, men and women reported differences in certain types of ACEs. It was found that people with a diagnosis and family history of mental illnesses presented a higher number of ACE categories.

show abstract

Does the association of child maltreatment with adult cardiovascular disease differ by gender?

Cited by 5 publications

References 8 publications

H2S and Oxytocin Systems in Early Life Stress and Cardiovascular Disease

H2S and Oxytocin Systems in Early Life Stress and Cardiovascular Disease

Biological Connection of Psychological Stress and Polytrauma under Intensive Care: The Role of Oxytocin and Hydrogen Sulfide

Adverse Childhood Experiences in Mexico: Prevalence and Association with Sociodemographic Variables and Health Status

Contact Info

Product

Resources

About