Does the Association of Sleep Quality with Central Sensitization in People with Knee Osteoarthritis Differ Depending on How It’s Measured? A Comparison of Quantitative Sensory Testing and the Central Sensitization Inventory

Abstract

We investigated the association of sleep quality with the Central Sensitization Inventory (CSI), pressure pain thresholds (PPT), temporal summation, and conditioned pain modulation (CPM) in 251 people with knee osteoarthritis, adjusted for sex, age, body mass index (BMI), anxiety-depressive symptoms, pain catastrophizing, fatigue, comorbidities, and radiographic severity. Overall, sleep quality was associated with changes in the CSI and PPT. However, when stratified by sex, only women had changes in sleep associated with the CSI, PPT, and CPM. Longitudinal studies should confirm these findings.

Feasibility of pain informed movement program for people with knee osteoarthritis

“…The pain experience and its associated mechanisms in people with knee osteoarthritis (KOA) are complex and multidimensional [ 1 ], with alterations in the peripheral and central nervous system leading to pain sensitization, persistent pain, and non-responsiveness to guideline-based physiotherapy [ 2 , 3 ]. Additionally, the severity of pain in KOA is associated with negative outcomes including sleep disturbances [ 4 ], psychological distress [ 5 ], functional limitations [ 6 ], and reduced quality of life [ 7 ]. With no disease modifying medications currently available and limited pain management strategies, understanding the underlying mechanisms of OA pain and designing treatment strategies to target those mechanisms is critical to improving pain management.…”