Does the bromocriptine-rebound method improve embryo quality?

Moride, Naoko; Kuwahara, Akira; Yamashita, Marie; Tanaka, Yu; Matsuzaki, Takashi; Irahara, Minoru

doi:10.2152/jmi.58.63

Cited by 4 publications

(6 citation statements)

References 11 publications

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“…Thus, the authors concluded that IVF failure is the consequence of a granulosa cell resistance to prolactin action and that the bromocriptine-induced hypoprolactinemia contributes to the restoration of prolactin responsiveness and, subsequently, improved oocytes maturation [ 87 ]. A more recent study confirmed the results with the BR method [ 88 ]. Bromocriptine was administered daily from day 5 of the preceding cycle until 7 days before ovarian stimulation in women with normal prolactin levels and previous repeated unsuccessful ART in a new long agonist protocol cycle and the results were compared with those of women treated with long agonist protocol only [ 88 ].…”

Section: The Role Of Dopamine Agonist Administration In Ivf Treatmentsupporting

confidence: 66%

“…A more recent study confirmed the results with the BR method [ 88 ]. Bromocriptine was administered daily from day 5 of the preceding cycle until 7 days before ovarian stimulation in women with normal prolactin levels and previous repeated unsuccessful ART in a new long agonist protocol cycle and the results were compared with those of women treated with long agonist protocol only [ 88 ]. The number of retrieved oocytes was the same in both groups; however, superior results were obtained with the BR method in terms of the number of fertilized oocytes, cleaved embryos, transplanted embryos, the ratio of good embryos, embryo score, and clinical pregnancy rates.…”

Section: The Role Of Dopamine Agonist Administration In Ivf Treatmentsupporting

confidence: 66%

“…The number of retrieved oocytes was the same in both groups; however, superior results were obtained with the BR method in terms of the number of fertilized oocytes, cleaved embryos, transplanted embryos, the ratio of good embryos, embryo score, and clinical pregnancy rates. The authors concluded that this method could be of value in attaining superior-quality embryos and transplantation rates in women with previous unsuccessful IVF/ICSI ( Table 1 ) [ 88 ].…”

Section: The Role Of Dopamine Agonist Administration In Ivf Treatmentmentioning

confidence: 99%

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Prolactin Relationship with Fertility and In Vitro Fertilization Outcomes—A Review of the Literature

Iancu¹,

Albu

2023

Pharmaceuticals

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Hyperprolactinemia is a known cause of amenorrhea and infertility. However, there is an increasing body of evidence suggesting that prolactin is involved in multiple physiological aspects of normal reproduction. Thus, the present paper aims to review the current literature regarding the relationship between serum prolactin level and in vitro fertilization (IVF)/intracytoplasmic sperm injection outcome and the role of dopamine agonists treatment in IVF success. Moreover, the mechanisms by which prolactin may exert its role in fertility and infertility were summarized. Although not all studies agree, the available evidence suggests that higher prolactin levels in follicular fluid are associated with increased oocytes competence, but also with positive effects on corpus luteum formation and survival, endometrial receptivity, blastocyst implantation potential and survival of low-motile sperm. Transient hyperprolactinemia found in IVF cycles was reported in most of the studies not to be related to IVF outcome, although a few reports suggested that it may be associated with higher implantation and pregnancy rates, and better-cumulated pregnancy outcomes. Administration of dopamine agonists for hyperprolactinemia preceding IVF treatment does not seem to negatively impact the IVF results, while treatment of transient hyperprolactinemia during IVF might be beneficial in terms of fertilization rates and conception rates. Due to limited available evidence, future studies are necessary to clarify the optimal level of circulating prolactin in patients performing IVF and the role of dopamine agonist treatment.

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Section: The Role Of Dopamine Agonist Administration In Ivf Treatmentsupporting

confidence: 66%

Section: The Role Of Dopamine Agonist Administration In Ivf Treatmentsupporting

confidence: 66%

Section: The Role Of Dopamine Agonist Administration In Ivf Treatmentmentioning

confidence: 99%

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Prolactin Relationship with Fertility and In Vitro Fertilization Outcomes—A Review of the Literature

Iancu¹,

Albu

2023

Pharmaceuticals

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“…This was attributed to better oocyte maturation which was achieved due to the rebound increase of prolactin after the discontinuation of bromocriptine, which restored post receptor responsiveness in granulosa cells. Moride et al [ 25 ] also concluded that the bromcriptine rebound method yielded morphologically better embryos.…”

Section: Discussionmentioning

confidence: 99%

Changes in serum prolactin level during intracytoplasmic sperm injection, and effect on clinical pregnancy rate: a prospective observational study

Kamel

Halim

Shehata

et al. 2018

BMC Pregnancy Childbirth

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BackgroundTransient hyperprolactinemia was proven to adversely affect the outcome of IVF. We aimed to identify changes in serum prolactin levels in patients undergoing ICSI, and to evaluate the effect of these changes on the clinical pregnancy rate.MethodsA prospective observational study included 90 patients scheduled for ICSI cycles. In each case 4 serum samples were collected during the cycle (midluteal, before ovum pick up procedure (OPU), 2 h after OPU, and before embryo transfer). Serum prolactin level was determined by immunoassay each time.ResultsThe sample collected 2 h after OPU had a mean difference of 25.8 ± 2.8 ng/ml compared to the basal serum prolactin (p < 0.01). In comparison to other samples, this highlighted a significant hyperprolactinemia occurring after OPU, and resolving before embryo transfer. No statistically significant difference between the different serum prolactin samples amongst the pregnant and non pregnant patients. There was a significant positive pearson correlation between the prolactin levels before OPU, and the presence of higher quality embryos (r = 0.274, p = 0.019).ConclusionIn normoprolactinemic women transient hyperprolactinemia is identified in patients undergoing ICSI, and it doesn’t affect the clinical pregnancy rates. A positive correlation was identified between higher quality embryos, and serum prolactin level before OPU.Trial registrationClinicalTrials.gov Identifier: NCT02292953, First received: November 10, 2014.

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“…Since PRL improved oogenesis and embryonic development, some researchers have tried to improve the IVF outcomes by prescribing bromocriptine to patients with a history of recurrent implantation failure until the initiation day of rFSH. Therefore, PRL rebounded to a higher level, and the CPR did improve compared to that in the controls (10.1 vs. 27.2% P < 0.05) owing to the significantly increased PRL ( 13 ).…”

Section: Discussionmentioning

confidence: 86%

Mildly Higher Serum Prolactin Levels Are Directly Proportional to Cumulative Pregnancy Outcomes in in-vitro Fertilization/Intracytoplasmic Sperm Injection Cycles

et al. 2020

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Hyperprolactinemia has long been considered detrimental to fertility due to irregularity of ovulation. Whether mild hyperprolactinemia should be corrected before initiating an in-vitro fertilization/intracytoplasmic sperm injection cycle (IVF/ICSI) has not been determined; this study aimed to examine how different levels of prolactin affect IVF outcomes. A total of 3,009 patients with basal prolactin level <50 ng/mL undergoing IVF/ICSI cycles for tubal or male factors were recruited in this study. Patients diagnosed with anovulation owing to polycystic ovarian syndrome or hyperandrogenism were ruled out. Pregnancy outcomes were compared between patients with basal prolactin levels higher or lower than the median level of prolactin (16.05 ng/mL). Multifactor analyses were carried out among four subgroups depending on different prolactin levels. Repeated-measures analysis of variance was used to explore the relationship between the ascending trend of prolactin levels over ovarian stimulation and the corresponding cumulative pregnancy outcomes. There were significantly higher numbers of oocytes (9 vs. 8, P = 0.013) and embryos (6 vs. 5, P = 0.015) in patients with basal prolactin higher than 16.05 ng/mL. Basal prolactin higher than 30 ng/mL was positively related to cumulative clinical pregnancy, and a level higher than 40 ng/mL was a good indicator for the cumulative live birth rate. Throughout ovarian stimulation, the prognosis of pregnancy improved with increasing prolactin levels. Patients with better cumulated pregnancy outcomes had significantly higher prolactin levels as well as a profoundly increasing trend during the stimulating process than those who did not conceive. For patients who underwent the gonadotropin-releasing hormone agonist long protocol IVF/ICSI treatment, a slightly higher prolactin level during the controlled ovarian hyperstimulation protocol was a positive indicator for cumulated pregnancy/live birth rates.

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Does the bromocriptine-rebound method improve embryo quality?

Abstract: BR method could provide the better embryos and improve the transplantation rate in women with previous unsuccessful ART attempts.

Cited by 4 publications

References 11 publications

Prolactin Relationship with Fertility and In Vitro Fertilization Outcomes—A Review of the Literature

Prolactin Relationship with Fertility and In Vitro Fertilization Outcomes—A Review of the Literature

Changes in serum prolactin level during intracytoplasmic sperm injection, and effect on clinical pregnancy rate: a prospective observational study

Mildly Higher Serum Prolactin Levels Are Directly Proportional to Cumulative Pregnancy Outcomes in in-vitro Fertilization/Intracytoplasmic Sperm Injection Cycles

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