Does the Choice of Health Metric, DALY or QALY, Influence Conclusions of Health Economic Evaluation? A Case Study of Rotavirus Vaccine in Burundi

Niyibitegeka, Fulgence; Thavorncharoensap, Montarat; Riewpaiboon, Arthorn; Youngkong, Sitaporn

doi:10.1007/s40258-022-00722-3

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…In a previous case study, which investigated the influence of different health metrics on the conclusions drawn in health economic evaluations of rotavirus vaccination in Burundi, the use of DALYs led to more favourable cost-effective results than the use of QALYs. However, such effects were small and less likely to affect the analysis conclusion [40].…”

Section: Discussionmentioning

confidence: 98%

Economic Evaluation of Rotavirus Vaccination in Children Aged Under Five Years in South Africa

Mohy,

Page,

Boyce

et al. 2023

Clin Drug Investig

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Background and Objective Evidence on the economic value of rotavirus vaccines in middle-income countries is limited. We aimed to model the implementation of three vaccines (human rotavirus, live, attenuated, oral vaccine [HRV, 2 doses]; rotavirus vaccine, live, oral, pentavalent [HBRV, 3 doses] and rotavirus vaccine, live attenuated oral, freeze-dried [BRV-PV, 3 doses] presented in 1-dose and 2-dose vials) into the South African National Immunisation Programme. Methods Cost and cost-effectiveness analyses were conducted to compare three rotavirus vaccines using a static, deterministic, population model in children aged <5 years in South Africa from country payer and societal perspectives. Deterministic and probabilistic sensitivity analyses were conducted to assess the impact of uncertainty in model inputs. ResultsThe human rotavirus, live, attenuated, oral vaccine (HRV) was associated with cost savings versus HBRV from both perspectives, and versus BRV-PV 1-dose vial from the societal perspective. In the cost-effectiveness analysis, HRV was estimated to avoid 1,107 home care rotavirus gastroenteritis (RVGE) events, 247 medical visits, 35 hospitalisations, and 4 RVGErelated deaths versus HBRV and BRV-PV.

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Section: Discussionmentioning

confidence: 98%

Economic Evaluation of Rotavirus Vaccination in Children Aged Under Five Years in South Africa

Mohy,

Page,

Boyce

et al. 2023

Clin Drug Investig

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“…This has been shown to be a reliable method of calculating a UW from DWs. 9 The TTO and VAS were used for the UW calculations as these are direct evaluation methods, while the PR is not considered to be a direct evaluation method. 13 …”

Section: Methodsmentioning

confidence: 99%

“… 8 The UW for a disease in a specific setting can often be established as one minus the disability weight for that population. 9 As UWs are context-specific, they highlight populations where patients have a lower quality of life by reason of a particular disease.…”

Section: Introductionmentioning

confidence: 99%

An assessment of the impact of developmental dysplasia of the hip on patients’ wellbeing

et al. 2023

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AimsWithin healthcare, several measures are used to quantify and compare the severity of health conditions. Two common measures are disability weight (DW), a context-independent value representing severity of a health state, and utility weight (UW), a context-dependent measure of health-related quality of life. Neither of these measures have previously been determined for developmental dysplasia of the hip (DDH). The aim of this study is to determine the DW and country-specific UWs for DDH.MethodsA survey was created using three different methods to estimate the DW: a preference ranking exercise, time trade-off exercise, and visual analogue scale (VAS). Participants were fully licensed orthopaedic surgeons who were contacted through national and international orthopaedic organizations. A global DW was calculated using a random effects model through an inverse-variance approach. A UW was calculated for each country as one minus the country-specific DW composed of the time trade-off exercise and VAS.ResultsOver a four-month period, 181 surgeons participated in the survey, with 116 surgeons included in the final analysis. The global DW calculated to be 0.18 (0.11 to 0.24), and the country-specific UWs ranged from 0.26 to 0.89.ConclusionThis is the first time that a global disability weight and country-specific utility weights have been estimated for DDH, which should assist in economic evaluations and the development of health policy. The methodology may be applied to other orthopaedic conditions.Cite this article: Bone Jt Open 2023;4(3):120–128.

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Global burden of disease study at the world health organization: research methods for the most comprehensive global study of disease and underlying health policies

Smıth¹,

Shin²,

Hwang³

et al. 2022

Life Cycle

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The Global Burden of Disease (GBD) is a compass that navigates researchers and clinicians in discovering the latest knowledge and the current status of health for populations and countries worldwide. The GBD helps to present various methods in evaluating health-related quality of life and assess the health burden, economic burden, years of life lost, and healthy life-years lost from each disease. Beforehand, the details and development status of the dataset need to be identified, and the advantages and disadvantages of each research methodology should be analyzed. The aim of this paper is to help readers comprehend the above basic knowledge of GBD above a certain level. This paper also exemplifies some recent studies to help readers who yearn to understand in detail the latest research using GBD.

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Does the Choice of Health Metric, DALY or QALY, Influence Conclusions of Health Economic Evaluation? A Case Study of Rotavirus Vaccine in Burundi

Cited by 3 publications

References 39 publications

Economic Evaluation of Rotavirus Vaccination in Children Aged Under Five Years in South Africa

Economic Evaluation of Rotavirus Vaccination in Children Aged Under Five Years in South Africa

An assessment of the impact of developmental dysplasia of the hip on patients’ wellbeing

Global burden of disease study at the world health organization: research methods for the most comprehensive global study of disease and underlying health policies

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