Does the endometrial receptivity array really provide personalized embryo transfer?

Bassil, Rawad; Casper, Robert F.; Samara, Nivin; Hsieh, Tzu‐Bou; Barzilay, Eran; Orvieto, Raoul; Haas, Jigal

doi:10.1007/s10815-018-1190-9

Cited by 106 publications

(91 citation statements)

References 10 publications

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“…Considering how critical the molecular signature of the endometrium is for embryo implantation, a test which unequivocally assess if the embryo and the uterus are in synchrony may be of great value to avoid ineffective embryo transfers. However, the utility of ERA in the clinical practice is still debated [203]. More recently, a smaller set of genes has been proposed to assess the receptivity status of the endometrium in biopsies obtained in the secretory phase [204].…”

Section: Endometrial Receptivity Arraymentioning

confidence: 99%

Molecular Signaling Regulating Endometrium–Blastocyst Crosstalk

Massimiani

Lacconi

Civita

et al. 2019

IJMS

135

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Implantation of the embryo into the uterine endometrium is one of the most finely-regulated processes that leads to the establishment of a successful pregnancy. A plethora of factors are released in a time-specific fashion to synchronize the differentiation program of both the embryo and the endometrium. Indeed, blastocyst implantation in the uterus occurs in a limited time frame called the “window of implantation” (WOI), during which the maternal endometrium undergoes dramatic changes, collectively called “decidualization”. Decidualization is guided not just by maternal factors (e.g., estrogen, progesterone, thyroid hormone), but also by molecules secreted by the embryo, such as chorionic gonadotropin (CG) and interleukin-1β (IL-1 β), just to cite few. Once reached the uterine cavity, the embryo orients correctly toward the uterine epithelium, interacts with specialized structures, called pinopodes, and begins the process of adhesion and invasion. All these events are guided by factors secreted by both the endometrium and the embryo, such as leukemia inhibitory factor (LIF), integrins and their ligands, adhesion molecules, Notch family members, and metalloproteinases and their inhibitors. The aim of this review is to give an overview of the factors and mechanisms regulating implantation, with a focus on those involved in the complex crosstalk between the blastocyst and the endometrium.

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Section: Endometrial Receptivity Arraymentioning

confidence: 99%

Molecular Signaling Regulating Endometrium–Blastocyst Crosstalk

Massimiani

Lacconi

Civita

et al. 2019

IJMS

135

View full text Add to dashboard Cite

show abstract

“…57,72 However, optimal timing may vary between individuals, with research continuing to identify histological or genomic tests to determine the personalised window of implantation. [73][74][75][76][77][78] There is reasonable evidence that estrogen can be continued for several weeks before the introduction of progesterone in medicated FER with no adverse effect on clinical pregnancy rate. 79 Consequently, medicated FER offers flexibility over timing of embryo transfer, which is convenient for women and when managing clinic workflow.…”

Section: Hormone Replacement (Medicated) Frozen-thawed Embryo Replacementioning

confidence: 99%

The role of frozen–thawed embryo replacement cycles in assisted conception

Noble

Child

2019

The Obstetric & Gynaecologis

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Recent years have seen a dramatic rise in the number of frozenthawed embryo replacement (FER) cycles. Improved embryo cryopreservation techniques have resulted in outcomes for FER that are similar to fresh embryo transfer. FER maximises the cumulative live-birth rate of a fresh in vitro fertilisation (IVF) cycle by using excess embryos and encourages a policy of single embryo transfer; this has contributed to a fall in the multiple pregnancy rate associated with IVF. Freezing all suitable embryos in a fresh cycle reduces the risk of ovarian hyperstimulation syndrome. The endometrium is prepared for FER by a natural or medicated protocol; the optimum method is unknown. Learning objectives To appreciate the importance of FER in IVF practice. To understand the current debate surrounding fresh versus frozen IVF. To understand the indications for, and methods of, embryo cryopreservation. To understand the commonly used methods of endometrial preparation for FER. To be able to date an FER pregnancy. Ethical issues Funding from the National Health Service (NHS) for embryo storage and FER varies widely across the UK; where funding is limited, this can result in viable embryos being discarded. When an embryo is created by a couple, the consent of both partners is required before transferring the embryo.

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“…45 While this test is currently on offer commercially, there remains limited evidence of benefit for improving live birth both in good prognosis patients and in patients with RIF. [45][46][47] The older patient With the rapid decline in fecundity seen with advancing female age, coupled with the societal changes in preferred age for child-bearing, fertility is primarily becoming a disease of ageing. 48 Unlocking the means to improve the fertility potential of the ageing oocyte is the next frontier for 21st century ART and for developed societies.…”

Section: Advances In Endometrial Biologymentioning

confidence: 99%

“…An endometrial biopsy is collected in the mid‐luteal phase with results denoted as ‘pre‐receptive’, ‘receptive’ or ‘post‐receptive’, with as many as one in four patients having a non‐receptive endometrium, allowing adjustment of the timing of embryo transfer in a subsequent cycle . While this test is currently on offer commercially, there remains limited evidence of benefit for improving live birth both in good prognosis patients and in patients with RIF …”

Section: Introductionmentioning

confidence: 99%

In vitro fertilisation/intracytoplasmic sperm injection beyond 2020

Crawford

Ledger

2018

BJOG

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Over 8 million babies have been born following IVF (in vitro fertilisation) and other artificial reproductive technology (ART) procedures since Louise Brown's birth 40 years ago. New innovations have added much complexity to both clinical and laboratory procedures over the last four decades. Translation of novel approaches from basic science into clinical practice continues unabated, widening the applicability of ART to new groups of people and helping improve both chances of healthy live birth and patient acceptability. However, the impact of ART on the health of both patients and their offspring continues to cause concern, and many ethical challenges created by new scientific developments in this field attract widely differing opinions. What is undeniable is that there will be a sustained global growth in utilisation of ART and that reproductive tourism will allow many people to access the treatment they desire notwithstanding national regulations that may forbid some approaches. The greatest challenge is to expand access to ART to those living in the less wealthy nations who are equally deserving of its benefits.

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Does the endometrial receptivity array really provide personalized embryo transfer?

Cited by 106 publications

References 10 publications

Molecular Signaling Regulating Endometrium–Blastocyst Crosstalk

Molecular Signaling Regulating Endometrium–Blastocyst Crosstalk

The role of frozen–thawed embryo replacement cycles in assisted conception

In vitro fertilisation/intracytoplasmic sperm injection beyond 2020

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