Does the human immunodeficiency virus influence the vestibulocollic reflex pathways? A comparative study

Heinze, Barbara M.; Vinck, Bart; Swanepoel, De Wet

doi:10.1017/s0022215114001996

Cited by 5 publications

(7 citation statements)

References 30 publications

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“…This may indicate that the impact of viral disease happens in a progressive manner, thereby allowing for central compensation. Likewise, an impairment in the vestibular reflex pathways is possible in the course of acquired immune deficiency syndrome (AIDS) in addition to other systemic problems caused by the virus [26] . This impairment in AIDS could be attributed to involvement of dopaminergic systemin the central nervous system [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of balance after recovery from Covid-19 disease

et al. 2022

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Objective: To answer the question whether balance related systems have been affected in adults who recovered from Covid-19 disease. This is the first case-control study to assess balance objectively and quantitatively in Covid-19 disease. Methods: Thirty-seven patients who recovered from Covid-19 disease and 30 healthy controls were compared using Dizziness Handicap Inventory (DHI), Computerized Dynamic Posturography (CDP), Vestibular Evoked Myogenic Potentials(VEMP) and Video Head Impulse Test (v-HIT). Results: On CDP, the composite and visual general scores of the patients were significantly lower than controls (p<0.01). The v-HIT gains of the patients significantly decreased in the vertical semicircular canals compared to controls (p<0.01).There was a significant difference between the patients and controls regarding the absence of o-VEMPs (p<0.01) while the amplitudes and latencies were similar between the groups (p>0.05). Decreased P1/N1 amplitudes and elongated N1 latencies were found on c-VEMP testing (p<0.05). Anosmia, taste disorder and gender were not associated with subjective and objective test results (p>0.05). Conclusion: The Covid-19 disease can cause dizziness rather that incapacitating vertigo. Dizziness can be seen in almost one-fifth of the adult covid19 out-patients, which may be due to involvement of vestibular and visual systems,ortheir central connections. The squeals created in the balance related systems may be irreversible as they have persisted after the recovery of the patients. It is also plausible to anticipate more severe condition in the older patients who were treated in the intensive care units. In the long term follow up of the survivors, the need for balance rehabilitation programs should be remembered in order to minimize risks of falling down.

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Section: Discussionmentioning

confidence: 99%

Assessment of balance after recovery from Covid-19 disease

et al. 2022

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“…Therefore, our results might suggest some degree of vestibular impairments in persons with HIV (at this point of the disease) [2,5,6,11] that could interfere with the ability of this system to send accurate information to the central nervous system (CNS) to maintain postural stability. Another possible explanation is that persons with HIV could have impairments of vestibulo-ocular reflex (VOR) [22]. The VOR is responsible for stabilizing an image during rapid head movement [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

“…Another possible explanation is that persons with HIV could have impairments of vestibulo-ocular reflex (VOR) [22]. The VOR is responsible for stabilizing an image during rapid head movement [22][23][24]. This mechanism brings accurate information about the body orientation in space to the CNS [23].…”

Section: Discussionmentioning

confidence: 99%

Early signs of standing postural instability in asymptomatic people living with HIV

Rosario¹

2020

HIV & AIDS Review

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Introduction: People with human immunodeficiency virus (HIV) can present vestibular system impairments, affecting postural stability. There is limited literature related to visual and somatosensory systems in maintaining postural stability in HIV-positive people. The purpose of this study was to describe sensory systems used to maintain postural stability and how the sources of sensory information can influence postural stability in asymptomatic persons with HIV. Material and methods:Postural stability was measured in 20 asymptomatic persons with HIV with no history of fall (11 males, 9 females; aged 43 ± 8 years). Static postural stability was evaluated during eight conditions that perturbed the visual, somatosensory, and vestibular inputs. One-way MANOVA test was conducted to compare center of pressure (COP), antero-posterior displacement (APD), and right-left displacement (RLD) on a stable and unstable surface.Results: There was a significant increase in the COP, APD, and RLD when the proprioceptive system was challenged on the unstable surface.Conclusions: Postural instability can be detected in asymptomatic HIV-positive persons with challenging conditions before the evident appearance of balance impairments.

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“…Our outcomes revealed a deviation in the Fukuda score in most of the participants (table 1), showing vestibular issues towards the same side the rotation occurred [17]. Therefore, vestibular problems, prevalent in those living with HIV [7][8] are another reasonable factor provoking balance instability in this group.…”

Section: Discussionmentioning

confidence: 67%

“…Individuals diagnosed with HIV can have neurological deficits that disturb the systems responsible for maintaining balance. Some of these neurological deficits provoking balance instability include vestibular involvement [7][8], lower leg neuromuscular system [9], and proprioceptive input [10]. Balance instability in those with HIV is displayed as a smaller functional BoS [11], considerably decreased limits of stability, and diminished stance stability [12] compared to healthy controls.…”

Section: Introductionmentioning

confidence: 99%

"Single Limb Support Instability combined with Vestibular and Proprioceptive Alteration in Hispanic Latinx Living with HIV"

Rosario

Bowman

Corrigan

et al. 2022

ijphy

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Healthy individuals can maintain static and dynamic balance via appropriate allocation among proprioceptive (Pro), vestibular (Ve), and visual sensory systems, established as the dynamic systems theory (DST). However, people living with the human immunodeficiency virus (PLHIV) underperform one or more of these systems, altering their ability to control balance. The issue is to determine specific balance system deficits in PLHIV during many challenging standing tasks to understand better where these deficiencies are located. The study aims to distinguish balance deficits in PLHIV using challenging activities with a reduced base of support. Methods: Thirty adults living with HIV from La Perla Gran de Precio Community Center took part in this examination. We collected balance kinematics with accelerometers and gyroscopes during five balancing tasks. The five tasks included balancing on a firm surface with double limb support (DLS) and single limb support (SLS) and balancing tasks on an unstable surface (foam) with vertical head movements at 60 bpm set by a metronome. Results: The balancing tasks requiring shifts from SL to DL on firm and foam surfaces with visual input alterations (eyes closed and open) and head movements showed significant increases in sway (p<0.001). The medial-lateral (ML) and anterior-posterior (AP) sway velocities displayed substantial increases (p<0.001) in AP sway among all five tasks and a considerable decrease in ML among the five tasks. Conclusion: People living with HIV have balance instability, with increased difficulty during conditions requiring to bear weight on a single limb with Ve and Pro adaptations. The mechanism creating these deficits in the Ve and Pro systems is yet unsettled. Future studies should focus on 1) early assessment of Ve and Pro, 2) the mechanisms affecting said balance systems, and 3) the correlation of ART medications with balance and fall risk in this population.

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Does the human immunodeficiency virus influence the vestibulocollic reflex pathways? A comparative study

Abstract: Abstract:Background: This study compared vestibulocollic reflex (VCR) and vestibulo-ocular reflex (VOR)

Cited by 5 publications

References 30 publications

Assessment of balance after recovery from Covid-19 disease

Assessment of balance after recovery from Covid-19 disease

Early signs of standing postural instability in asymptomatic people living with HIV

"Single Limb Support Instability combined with Vestibular and Proprioceptive Alteration in Hispanic Latinx Living with HIV"

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